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Protein

Protein arginine N-methyltransferase 2

Gene

RMT2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei254S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei285S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei378S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:RMT2By similarity
Ordered Locus Names:YALI0C14718g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289791 – 475Protein arginine N-methyltransferase 2Add BLAST475

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi4952.XP_501840.1

Structurei

3D structure databases

ProteinModelPortaliQ6CBX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 475RMT2PROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni310 – 315S-adenosyl-L-methionine bindingPROSITE-ProRule annotation6
Regioni331 – 333S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni358 – 359S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214351
InParanoidiQ6CBX2
KOiK18477
OMAiSGAIWND
OrthoDBiEOG092C2OT7

Family and domain databases

InterProiView protein in InterPro
IPR017408 Arginine_N-MeTrfase_2
IPR026480 RMT2_dom
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF038148 Arginine_N-mtfrase-2, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51559 SAM_RMT2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CBX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFTEEETKL GKSLFEACSF TERPIAKDSH LETVRQVMRK NIPATITTSD
60 70 80 90 100
LGLFTDEEEA TKKKEIIQGD ITIDGTTPLH VICSSFPSDA TAEELEVALE
110 120 130 140 150
MMRELFQWGA GWMLLDEQGQ TPGCVAWDRS KAEARDSVLA SVYNEIVSAG
160 170 180 190 200
TRSEVFLRRI NKSENVEFLS DDDDEEMDVD DDEEDESRDG EETGDIQQAI
210 220 230 240 250
ADAIKQAKEA GLEVVVDGET VEEVPELVGD KEDEKNNESA AQNEVDLAGS
260 270 280 290 300
QMDYLKDKLT YTDDNKTLIT TQNDGVMMDW EDEIMQKSAD LLVSRADKES
310 320 330 340 350
DGPVVLNVGF GLGIIDTYLQ SKKPSKHYIC EAHPDVLEKM EKDGWMDKPG
360 370 380 390 400
VTVLVGRWQD TLPGLLSQGV YFDGMYYDTF SENYSDLVDF FDHVVGLLAP
410 420 430 440 450
TGVFSFFNGL GADRQVCYDV YKNVVEVDLQ EYGLNVEYQV IKVNKDVTGA
460 470
DGHVWDGIKR RYWVVEDFYL PVCTF
Length:475
Mass (Da):53,328
Last modified:August 16, 2004 - v1
Checksum:i86B6620419DB3E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA Translation: CAG82151.1
RefSeqiXP_501840.1, XM_501840.1

Genome annotation databases

EnsemblFungiiCAG82151; CAG82151; YALI0_C14718g
GeneIDi2909738
KEGGiyli:YALI0C14718g

Similar proteinsi

Entry informationi

Entry nameiRMT2_YARLI
AccessioniPrimary (citable) accession number: Q6CBX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health