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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

ETR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton donorBy similarity1
Binding sitei160NADPBy similarity1
Binding sitei368NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi183 – 186NADPBy similarity4
Nucleotide bindingi206 – 208NADPBy similarity3
Nucleotide bindingi277 – 280NADPBy similarity4
Nucleotide bindingi302 – 304NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
Name:ETR1
Ordered Locus Names:YALI0C19624g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12MitochondrionSequence analysisAdd BLAST12
ChainiPRO_000000090413 – 376Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST364

Proteomic databases

PRIDEiQ6CBE4

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4952.XP_502018.1

Structurei

3D structure databases

ProteinModelPortaliQ6CBE4
SMRiQ6CBE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683
InParanoidiQ6CBE4
KOiK07512
OMAiAFRGFWM
OrthoDBiEOG092C2NJA

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CBE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTLRTSQL ARSGFGTPSF GLRFNSVGRA FVFSQTGEPK DVIQVLEYPI
60 70 80 90 100
EKPLENQVLL KSLGFTINPA DINQLEGVYP SVPPKSVQIN NEDAAIGGNE
110 120 130 140 150
GLFQVLDPGA KSGLKKGDWV LPRKTCFGTW RSHALVEADT VVKIDNTDLT
160 170 180 190 200
KVQATTVSVN PSTAYEMLKD LKEGDWFIQN GGNSGVGRAA IQIGHIRGLK
210 220 230 240 250
SISVVRDRPD LEVLKKELTD LGATHVITEE EASDKLFSKQ IKSWTGGKIK
260 270 280 290 300
LALNCIGGKS ATSIMRQLGA GGSIVTYGGM SKKPLTFPTG PFIFKDITAK
310 320 330 340 350
GYWLTRWADK HPEEKAKTIE NIFKFYREKK FVAPPVNIST LDFSKGNDVV
360 370
LSEFLDALGK AQKGGGKKQL VQWVEY
Length:376
Mass (Da):41,206
Last modified:August 16, 2004 - v1
Checksum:iE085FF7C32379DCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA Translation: CAG82338.1
RefSeqiXP_502018.1, XM_502018.1

Genome annotation databases

EnsemblFungiiCAG82338; CAG82338; YALI0_C19624g
GeneIDi2909944
KEGGiyli:YALI0C19624g

Similar proteinsi

Entry informationi

Entry nameiETR1_YARLI
AccessioniPrimary (citable) accession number: Q6CBE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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