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Q6CBE4

- ETR1_YARLI

UniProt

Q6CBE4 - ETR1_YARLI

Protein

Probable trans-2-enoyl-CoA reductase, mitochondrial

Gene

ETR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei160 – 1601NADPBy similarity
    Binding sitei368 – 3681NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi183 – 1864NADPBy similarity
    Nucleotide bindingi206 – 2083NADPBy similarity
    Nucleotide bindingi277 – 2804NADPBy similarity
    Nucleotide bindingi302 – 3043NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
    Gene namesi
    Name:ETR1
    Ordered Locus Names:YALI0C19624g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome C

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1212MitochondrionSequence AnalysisAdd
    BLAST
    Chaini13 – 376364Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000904Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi4952.Q6CBE4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CBE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000294683.
    KOiK07512.
    OMAiCSTLWRV.
    OrthoDBiEOG7PS1RH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CBE4-1 [UniParc]FASTAAdd to Basket

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    MLRTLRTSQL ARSGFGTPSF GLRFNSVGRA FVFSQTGEPK DVIQVLEYPI    50
    EKPLENQVLL KSLGFTINPA DINQLEGVYP SVPPKSVQIN NEDAAIGGNE 100
    GLFQVLDPGA KSGLKKGDWV LPRKTCFGTW RSHALVEADT VVKIDNTDLT 150
    KVQATTVSVN PSTAYEMLKD LKEGDWFIQN GGNSGVGRAA IQIGHIRGLK 200
    SISVVRDRPD LEVLKKELTD LGATHVITEE EASDKLFSKQ IKSWTGGKIK 250
    LALNCIGGKS ATSIMRQLGA GGSIVTYGGM SKKPLTFPTG PFIFKDITAK 300
    GYWLTRWADK HPEEKAKTIE NIFKFYREKK FVAPPVNIST LDFSKGNDVV 350
    LSEFLDALGK AQKGGGKKQL VQWVEY 376
    Length:376
    Mass (Da):41,206
    Last modified:August 16, 2004 - v1
    Checksum:iE085FF7C32379DCB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382129 Genomic DNA. Translation: CAG82338.1.
    RefSeqiXP_502018.1. XM_502018.1.

    Genome annotation databases

    EnsemblFungiiCAG82338; CAG82338; YALI0_C19624g.
    GeneIDi2909944.
    KEGGiyli:YALI0C19624g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382129 Genomic DNA. Translation: CAG82338.1 .
    RefSeqi XP_502018.1. XM_502018.1.

    3D structure databases

    ProteinModelPortali Q6CBE4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CBE4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG82338 ; CAG82338 ; YALI0_C19624g .
    GeneIDi 2909944.
    KEGGi yli:YALI0C19624g.

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000294683.
    KOi K07512.
    OMAi CSTLWRV.
    OrthoDBi EOG7PS1RH.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiETR1_YARLI
    AccessioniPrimary (citable) accession number: Q6CBE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3