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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

ETR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton donorBy similarity1
Binding sitei160NADPBy similarity1
Binding sitei368NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi183 – 186NADPBy similarity4
Nucleotide bindingi206 – 208NADPBy similarity3
Nucleotide bindingi277 – 280NADPBy similarity4
Nucleotide bindingi302 – 304NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
Name:ETR1
Ordered Locus Names:YALI0C19624g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome C

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12MitochondrionSequence analysisAdd BLAST12
ChainiPRO_000000090413 – 376Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST364

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4952.XP_502018.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CBE4.
SMRiQ6CBE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683.
InParanoidiQ6CBE4.
KOiK07512.
OMAiAFRGFWM.
OrthoDBiEOG092C2NJA.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CBE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTLRTSQL ARSGFGTPSF GLRFNSVGRA FVFSQTGEPK DVIQVLEYPI
60 70 80 90 100
EKPLENQVLL KSLGFTINPA DINQLEGVYP SVPPKSVQIN NEDAAIGGNE
110 120 130 140 150
GLFQVLDPGA KSGLKKGDWV LPRKTCFGTW RSHALVEADT VVKIDNTDLT
160 170 180 190 200
KVQATTVSVN PSTAYEMLKD LKEGDWFIQN GGNSGVGRAA IQIGHIRGLK
210 220 230 240 250
SISVVRDRPD LEVLKKELTD LGATHVITEE EASDKLFSKQ IKSWTGGKIK
260 270 280 290 300
LALNCIGGKS ATSIMRQLGA GGSIVTYGGM SKKPLTFPTG PFIFKDITAK
310 320 330 340 350
GYWLTRWADK HPEEKAKTIE NIFKFYREKK FVAPPVNIST LDFSKGNDVV
360 370
LSEFLDALGK AQKGGGKKQL VQWVEY
Length:376
Mass (Da):41,206
Last modified:August 16, 2004 - v1
Checksum:iE085FF7C32379DCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG82338.1.
RefSeqiXP_502018.1. XM_502018.1.

Genome annotation databases

EnsemblFungiiCAG82338; CAG82338; YALI0_C19624g.
GeneIDi2909944.
KEGGiyli:YALI0C19624g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiETR1_YARLI
AccessioniPrimary (citable) accession number: Q6CBE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: July 5, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families