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Protein

Probable trans-2-enoyl-CoA reductase, mitochondrial

Gene

ETR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei160 – 1601NADPBy similarity
Binding sitei368 – 3681NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi183 – 1864NADPBy similarity
Nucleotide bindingi206 – 2083NADPBy similarity
Nucleotide bindingi277 – 2804NADPBy similarity
Nucleotide bindingi302 – 3043NADPBy similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:ETR1
Ordered Locus Names:YALI0C19624g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome C

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212MitochondrionSequence AnalysisAdd
BLAST
Chaini13 – 376364Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000904Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4952.Q6CBE4.

Structurei

3D structure databases

ProteinModelPortaliQ6CBE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
InParanoidiQ6CBE4.
KOiK07512.
OMAiCRAWGIN.
OrthoDBiEOG7PS1RH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CBE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRTLRTSQL ARSGFGTPSF GLRFNSVGRA FVFSQTGEPK DVIQVLEYPI
60 70 80 90 100
EKPLENQVLL KSLGFTINPA DINQLEGVYP SVPPKSVQIN NEDAAIGGNE
110 120 130 140 150
GLFQVLDPGA KSGLKKGDWV LPRKTCFGTW RSHALVEADT VVKIDNTDLT
160 170 180 190 200
KVQATTVSVN PSTAYEMLKD LKEGDWFIQN GGNSGVGRAA IQIGHIRGLK
210 220 230 240 250
SISVVRDRPD LEVLKKELTD LGATHVITEE EASDKLFSKQ IKSWTGGKIK
260 270 280 290 300
LALNCIGGKS ATSIMRQLGA GGSIVTYGGM SKKPLTFPTG PFIFKDITAK
310 320 330 340 350
GYWLTRWADK HPEEKAKTIE NIFKFYREKK FVAPPVNIST LDFSKGNDVV
360 370
LSEFLDALGK AQKGGGKKQL VQWVEY
Length:376
Mass (Da):41,206
Last modified:August 16, 2004 - v1
Checksum:iE085FF7C32379DCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG82338.1.
RefSeqiXP_502018.1. XM_502018.1.

Genome annotation databases

EnsemblFungiiCAG82338; CAG82338; YALI0_C19624g.
GeneIDi2909944.
KEGGiyli:YALI0C19624g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG82338.1.
RefSeqiXP_502018.1. XM_502018.1.

3D structure databases

ProteinModelPortaliQ6CBE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.Q6CBE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG82338; CAG82338; YALI0_C19624g.
GeneIDi2909944.
KEGGiyli:YALI0C19624g.

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
InParanoidiQ6CBE4.
KOiK07512.
OMAiCRAWGIN.
OrthoDBiEOG7PS1RH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiETR1_YARLI
AccessioniPrimary (citable) accession number: Q6CBE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.