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Q6CBE4 (ETR1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Gene names
Name:ETR1
Ordered Locus Names:YALI0C19624g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontrans-2-enoyl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1212Mitochondrion Potential
Chain13 – 376364Probable trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000000904

Regions

Nucleotide binding183 – 1864NADP By similarity
Nucleotide binding206 – 2083NADP By similarity
Nucleotide binding277 – 2804NADP By similarity
Nucleotide binding302 – 3043NADP By similarity

Sites

Binding site1601NADP By similarity
Binding site3681NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CBE4 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: E085FF7C32379DCB

FASTA37641,206
        10         20         30         40         50         60 
MLRTLRTSQL ARSGFGTPSF GLRFNSVGRA FVFSQTGEPK DVIQVLEYPI EKPLENQVLL 

        70         80         90        100        110        120 
KSLGFTINPA DINQLEGVYP SVPPKSVQIN NEDAAIGGNE GLFQVLDPGA KSGLKKGDWV 

       130        140        150        160        170        180 
LPRKTCFGTW RSHALVEADT VVKIDNTDLT KVQATTVSVN PSTAYEMLKD LKEGDWFIQN 

       190        200        210        220        230        240 
GGNSGVGRAA IQIGHIRGLK SISVVRDRPD LEVLKKELTD LGATHVITEE EASDKLFSKQ 

       250        260        270        280        290        300 
IKSWTGGKIK LALNCIGGKS ATSIMRQLGA GGSIVTYGGM SKKPLTFPTG PFIFKDITAK 

       310        320        330        340        350        360 
GYWLTRWADK HPEEKAKTIE NIFKFYREKK FVAPPVNIST LDFSKGNDVV LSEFLDALGK 

       370 
AQKGGGKKQL VQWVEY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382129 Genomic DNA. Translation: CAG82338.1.
RefSeqXP_502018.1. XM_502018.1.

3D structure databases

ProteinModelPortalQ6CBE4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CBE4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG82338; CAG82338; YALI0_C19624g.
GeneID2909944.
KEGGyli:YALI0C19624g.

Phylogenomic databases

eggNOGCOG0604.
HOGENOMHOG000294683.
KOK07512.
OMACSTLWRV.
OrthoDBEOG7PS1RH.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Entry information

Entry nameETR1_YARLI
AccessionPrimary (citable) accession number: Q6CBE4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families