Q6CB52 (RUVB1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RuvB-like helicase 1
EC=3.6.4.12

Gene names

Name:	RVB1
Ordered Locus Names:	YALI0C21868g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia › Yarrowia lipolytica

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the RuvB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Chromatin regulator Helicase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA duplex unwinding Inferred from electronic annotation. Source: GOC DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Ino80 complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent 5'-3' DNA helicase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	RuvB-like helicase 1		PRO_0000165660
Regions
	Nucleotide binding	71 – 78	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6CB52 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: C364350A09949E06	FASTA	453	49,678
	10 20 30 40 50 60 MVQINEIKSN SRDTRTAAHT HIRGLGLNEM GVAKPIDAGF VGQTEAREAL GLVVDLIRAS 70 80 90 100 110 120 KMSGRGILLA GGPGTGKTAL ALAVSQELGP KVPFCPIVGS EIFSAEVKKT AALMENFRRA 130 140 150 160 170 180 IGLRIKETKD IYEGEVTELT PEEAEDPLGG YGKTIRSVVV GLKSYRGTKQ LRLDPKIYES 190 200 210 220 230 240 IQKERVAVGD VIYIEANTGA VKRVGRSDAY ATEFDLETEE YVPLPKGEVH KKKEIVQDVT 250 260 270 280 290 300 LHDLDVANAR PQGGQDVMSM MGSLMKPKKT EITDKLREEV NKKVQSYIDQ GVAELVPGVL 310 320 330 340 350 360 FIDEVNMLDV ECFTYLNRAL ESTISPIVIL ASNRGMCRVR GVDDDVSPHG ITTDLLDRLL 370 380 390 400 410 420 IVRTLPYSLD EIKTIIQKRA VVEQQQISED ALDALAQHGA RTSLRYGLQL LSPAGVLAKS 430 440 450 EGRDVVEVKD VEECESLFLD ATRSKGRFTD KFL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382129 Genomic DNA. Translation: CAG82430.1.
RefSeq	XP_502110.1. XM_502110.1.
3D structure databases
ProteinModelPortal	Q6CB52.
SMR	Q6CB52. Positions 8-445.
ModBase	Search...
Protein-protein interaction databases
STRING	4952.Q6CB52.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2909837.
KEGG	yli:YALI0C21868g.
Phylogenomic databases
eggNOG	COG1224.
HOGENOM	HOG000190885.
KO	K04499.
OMA	GNKVPFC.
OrthoDB	EOG4QJVWR.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR027238. RuvB-like. IPR010339. TIP49_C. [Graphical view]
PANTHER	PTHR11093. PTHR11093. 1 hit.
Pfam	PF06068. TIP49. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RUVB1_YARLI

Accession

Primary (citable) accession number: Q6CB52

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program