Q6CAB8 (GPI10_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GPI mannosyltransferase 3
EC=2.4.1.-

Alternative name(s):
GPI mannosyltransferase III
Short name=GPI-MT-III
Glycosylphosphatidylinositol-anchor biosynthesis protein 10

Gene names

Name:	GPI10
Ordered Locus Names:	YALI0D04202g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly By similarity.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 22 family. PIGB subfamily.

Ontologies

Keywords
Biological process	GPI-anchor biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	GPI anchor biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	GPI mannosyltransferase 3		PRO_0000246267
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Transmembrane	145 – 163	19	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Transmembrane	316 – 336	21	Helical; Potential
	Transmembrane	342 – 362	21	Helical; Potential
Amino acid modifications
	Glycosylation	290	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6CAB8 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 2C69B7C336A2B2C0	FASTA	510	58,336
	10 20 30 40 50 60 MMQHKEIKHP YQGIKYTVLV VIAAFRVANA LTTKTFFQPD EYWQSLEPAH RLAYGYGYLT 70 80 90 100 110 120 WEWHEGLRSS LPPLVGAGIY KALQLLGLDD PRIVRIAPKI VMALFASAGD VYTWKLSARL 130 140 150 160 170 180 QGPAEAPWAL FVSLLSAFNW FFLTRTFSNS AEMVLTAVAL NYWSFNGKEV NFKRLSVALF 190 200 210 220 230 240 IGAISCVLRP TNAILWAVLG LHLVLTTTAK MRVLWLAVRN VALVFAATYY IDYLYYGEPV 250 260 270 280 290 300 FPLLNFLKFN LLQSLAHFYG TSPTLYYFYE ALPLLTVGWL PLTLWGLWIN RSQVLVKAAL 310 320 330 340 350 360 AVVVAFSLIR HKEVRFIYPL VPILHMAAAE AITQTPKKLR KWLVWSLALV NILVAGYFSQ 370 380 390 400 410 420 VHQRGVVDVV EYLSTEPQVT SVGFLMPCHS TPYQSHLHRD IPVWFLTCEP PIGFTAEEQM 430 440 450 460 470 480 TYRDQADQFY DDPLQFVQTQ FPESVAVSAR EARTPLFHPS HLAIFESLEK KSPEVIEHLV 490 500 510 ELGYKRGKTF FNSHFHDDWR REGDVVVYNL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382130 Genomic DNA. Translation: CAG80582.1.
RefSeq	XP_502394.1. XM_502394.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CAB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2910629.
GenomeReviews	Gene locus YALI0D04202g in contig CR382130_GR.
KEGG	yli:YALI0D04202g.
Phylogenomic databases
eggNOG	fuNOG07781.
HOGENOM	HBG397465.
OMA	YLTWEWT.
OrthoDB	EOG40P7G0.
Family and domain databases
InterPro	IPR005599. GPI_mannosylTrfase. [Graphical view]
KO	K05286.
PANTHER	PTHR22760. Alg9_trans. 1 hit.
Pfam	PF03901. Glyco_transf_22. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPI10_YARLI

Accession

Primary (citable) accession number: Q6CAB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program