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Q6CA79

- MAP2_YARLI

UniProt

Q6CA79 - MAP2_YARLI

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Protein

Methionine aminopeptidase 2

Gene

MAP2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241SubstrateUniRule annotation
Metal bindingi244 – 2441Divalent metal cation 1UniRule annotation
Metal bindingi255 – 2551Divalent metal cation 1UniRule annotation
Metal bindingi255 – 2551Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi324 – 3241Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei332 – 3321SubstrateUniRule annotation
Metal bindingi357 – 3571Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi452 – 4521Divalent metal cation 1UniRule annotation
Metal bindingi452 – 4521Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2UniRule annotation
Short name:
MetAP 2UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
Name:MAP2UniRule annotation
Ordered Locus Names:YALI0D05159g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome D

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Methionine aminopeptidase 2PRO_0000407673Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CA79.

Structurei

3D structure databases

ProteinModelPortaliQ6CA79.
SMRiQ6CA79. Positions 68-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 6414Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0024.
HOGENOMiHOG000226278.
InParanoidiQ6CA79.
KOiK01265.
OMAiIQICEEL.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CA79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEAIEKVAD KVADLVVDDK PAAVPESTSD HEDGDDNDDA VNEGEAVDGE
60 70 80 90 100
KKKKKKKNKK KKKKGPAVQT EPPTVPIDRF FTSGIFPEGE ICEHPHKTFK
110 120 130 140 150
PKGTAVDPFA DSEDEREAAE ERAKDDAKHG SDDPLDFNRL RTTNEEKRYL
160 170 180 190 200
DREQAAVHNE WRKGAEIHRV VRKYARDNIK AGMTMTSIAE MIEDSVRALS
210 220 230 240 250
NEEDSLKGGQ GFPTGVSLNH CAAHYTPNAG DKIVLKEDDV LKVDFGVHVN
260 270 280 290 300
GKIIDSAFTH VQNDKWQGLL DAVKAATETG IREAGIDVRL GDIGEAIQET
310 320 330 340 350
MESHEVEVDG KVYQVKSIRN LNGHNIAPYE IHGGKSVPIV KSADMTKMEE
360 370 380 390 400
GETFAIETFG STGRGYVVTD GECSHYAKNV GVGHVPLRVN KAKQLLATID
410 420 430 440 450
KNFGTLPFCR RYLDRLGEEK YLLALKNLVQ SGVVQDYPPL VDQKGCQTAQ
460 470
YEHTIYLRPT CKEILSRGDD Y
Length:471
Mass (Da):52,156
Last modified:August 16, 2004 - v1
Checksum:i6990F681D67BBD0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG80621.1.
RefSeqiXP_502433.1. XM_502433.1.

Genome annotation databases

EnsemblFungiiCAG80621; CAG80621; YALI0_D05159g.
GeneIDi2910974.
KEGGiyli:YALI0D05159g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG80621.1 .
RefSeqi XP_502433.1. XM_502433.1.

3D structure databases

ProteinModelPortali Q6CA79.
SMRi Q6CA79. Positions 68-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CA79.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG80621 ; CAG80621 ; YALI0_D05159g .
GeneIDi 2910974.
KEGGi yli:YALI0D05159g.

Phylogenomic databases

eggNOGi COG0024.
HOGENOMi HOG000226278.
InParanoidi Q6CA79.
KOi K01265.
OMAi IQICEEL.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiMAP2_YARLI
AccessioniPrimary (citable) accession number: Q6CA79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3