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Protein

NEDD8-conjugating enzyme UBC12

Gene

UBC12

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins.By similarity

Catalytic activityi

ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine.

Pathwayi: protein neddylation

This protein is involved in the pathway protein neddylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein neddylation and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00885.

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD8-conjugating enzyme UBC12 (EC:6.3.2.-)
Alternative name(s):
RUB1-conjugating enzyme
RUB1-protein ligase
Ubiquitin carrier protein 12
Gene namesi
Name:UBC12
Ordered Locus Names:YALI0D07890g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome D

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179NEDD8-conjugating enzyme UBC12PRO_0000082500Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6C9W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233456.
InParanoidiQ6C9W0.
KOiK10579.
OMAiHEPPKVR.
OrthoDBiEOG092C5L1U.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C9W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIWSMKEK QAAEGGSAKK KVTAAQLRVQ KDLSELSLPS TMKTHFPSAE
60 70 80 90 100
DIMNFELTVR PDEGFYQGGE FRFSFYVNPN FPHEPPKVKC LQKVYHPNID
110 120 130 140 150
LEGNVCLNIL REDWKPVLSL NAVMIGLQYL FLEPNASDPL NKDAAHQMTA
160 170
NREEFKRNVK HSMAGGSVAG ERFDCVLIK
Length:179
Mass (Da):20,271
Last modified:August 16, 2004 - v1
Checksum:i38434BAC88FF21D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA. Translation: CAG80740.1.
RefSeqiXP_502552.1. XM_502552.1.

Genome annotation databases

EnsemblFungiiCAG80740; CAG80740; YALI0_D07890g.
GeneIDi2910945.
KEGGiyli:YALI0D07890g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA. Translation: CAG80740.1.
RefSeqiXP_502552.1. XM_502552.1.

3D structure databases

ProteinModelPortaliQ6C9W0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG80740; CAG80740; YALI0_D07890g.
GeneIDi2910945.
KEGGiyli:YALI0D07890g.

Phylogenomic databases

HOGENOMiHOG000233456.
InParanoidiQ6C9W0.
KOiK10579.
OMAiHEPPKVR.
OrthoDBiEOG092C5L1U.

Enzyme and pathway databases

UniPathwayiUPA00885.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBC12_YARLI
AccessioniPrimary (citable) accession number: Q6C9W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.