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Q6C9T3 (ALG11_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:ALG11
Ordered Locus Names:YALI0D08558g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase group 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000080279

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane304 – 32421Helical; Potential

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6C9T3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 50814E76F2CD6018

FASTA63571,363
        10         20         30         40         50         60 
MALQLDLPTL HDLRVVLNAD FLAALAALLL LAVILVPLCS YISLYAWSAI LAFKLRSPPA 

        70         80         90        100        110        120 
NWEKSIVKGV QANGTSTLFG FGFWQAAAVR RQLILQSNDP SYYSVTHVSR RSEIAISPED 

       130        140        150        160        170        180 
RNTEFRNRAQ DSGAPRRVIY GFFHPYANAG GGGERVLWAA VKDTLMYDDN IICAIYCGEQ 

       190        200        210        220        230        240 
DLPTRTSPST VLDAAVSNFH VTELADKELR KRIVFIGMRG RRLVDPKTWP RFTLMMQAAG 

       250        260        270        280        290        300 
SVWMAWHGIS TLVPDVFVDT MGYPFAYPLV SWVTHVPVAA YVHYPVISKD MLATVSLKQS 

       310        320        330        340        350        360 
PVRAALAVAK LVYWRVFALT YTFAGSYCSV VMTNSSWTNN HMQHMWWYNH KAEHIKIVYP 

       370        380        390        400        410        420 
PCGTQALSEI AMSEETSARS PNIVYIAQFR PEKRHDIVLR EFNKFYKEYT EKYPNQPAPH 

       430        440        450        460        470        480 
LTFVGTVRND DDKSRVYLLR LQARDLVNPD SVSFVLDAPF DKVRDILRTA SMGVNAMWNE 

       490        500        510        520        530        540 
HFGIVVVEYM SAGLIPVVHN SGGPKCDIVV PYEGQSTGNS GTLSAMPSST SIRSHYEAVP 

       550        560        570        580        590        600 
PGPTGFHFNC PGSDPTTDSG PSYDGEPIGT LAETLMRAFE LSESDTHNMR ARARESVKKR 

       610        620        630 
FSNEQFGSHW QVRMRILEKL EQIRRGHRLT RGDFD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382130 Genomic DNA. Translation: CAG80767.1.
RefSeqXP_502579.1. XM_502579.1.

3D structure databases

ProteinModelPortalQ6C9T3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C9T3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG80767; CAG80767; YALI0_D08558g.
GeneID2910710.
KEGGyli:YALI0D08558g.

Phylogenomic databases

eggNOGCOG0438.
HOGENOMHOG000209670.
KOK03844.
OMAHPYANNG.
OrthoDBEOG7673KQ.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALG11_YARLI
AccessionPrimary (citable) accession number: Q6C9T3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways