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Q6C9T3

- ALG11_YARLI

UniProt

Q6C9T3 - ALG11_YARLI

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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi

GO - Molecular functioni

  1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:ALG11
Ordered Locus Names:YALI0D08558g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome D

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6C9T3.

Structurei

3D structure databases

ProteinModelPortaliQ6C9T3.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000209670.
InParanoidiQ6C9T3.
KOiK03844.
OMAiHPYANNG.
OrthoDBiEOG7673KQ.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C9T3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALQLDLPTL HDLRVVLNAD FLAALAALLL LAVILVPLCS YISLYAWSAI
60 70 80 90 100
LAFKLRSPPA NWEKSIVKGV QANGTSTLFG FGFWQAAAVR RQLILQSNDP
110 120 130 140 150
SYYSVTHVSR RSEIAISPED RNTEFRNRAQ DSGAPRRVIY GFFHPYANAG
160 170 180 190 200
GGGERVLWAA VKDTLMYDDN IICAIYCGEQ DLPTRTSPST VLDAAVSNFH
210 220 230 240 250
VTELADKELR KRIVFIGMRG RRLVDPKTWP RFTLMMQAAG SVWMAWHGIS
260 270 280 290 300
TLVPDVFVDT MGYPFAYPLV SWVTHVPVAA YVHYPVISKD MLATVSLKQS
310 320 330 340 350
PVRAALAVAK LVYWRVFALT YTFAGSYCSV VMTNSSWTNN HMQHMWWYNH
360 370 380 390 400
KAEHIKIVYP PCGTQALSEI AMSEETSARS PNIVYIAQFR PEKRHDIVLR
410 420 430 440 450
EFNKFYKEYT EKYPNQPAPH LTFVGTVRND DDKSRVYLLR LQARDLVNPD
460 470 480 490 500
SVSFVLDAPF DKVRDILRTA SMGVNAMWNE HFGIVVVEYM SAGLIPVVHN
510 520 530 540 550
SGGPKCDIVV PYEGQSTGNS GTLSAMPSST SIRSHYEAVP PGPTGFHFNC
560 570 580 590 600
PGSDPTTDSG PSYDGEPIGT LAETLMRAFE LSESDTHNMR ARARESVKKR
610 620 630
FSNEQFGSHW QVRMRILEKL EQIRRGHRLT RGDFD
Length:635
Mass (Da):71,363
Last modified:August 16, 2004 - v1
Checksum:i50814E76F2CD6018
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG80767.1.
RefSeqiXP_502579.1. XM_502579.1.

Genome annotation databases

EnsemblFungiiCAG80767; CAG80767; YALI0_D08558g.
GeneIDi2910710.
KEGGiyli:YALI0D08558g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG80767.1 .
RefSeqi XP_502579.1. XM_502579.1.

3D structure databases

ProteinModelPortali Q6C9T3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C9T3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG80767 ; CAG80767 ; YALI0_D08558g .
GeneIDi 2910710.
KEGGi yli:YALI0D08558g.

Phylogenomic databases

eggNOGi COG0438.
HOGENOMi HOG000209670.
InParanoidi Q6C9T3.
KOi K03844.
OMAi HPYANNG.
OrthoDBi EOG7673KQ.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiALG11_YARLI
AccessioniPrimary (citable) accession number: Q6C9T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3