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Q6C9T3

- ALG11_YARLI

UniProt

Q6C9T3 - ALG11_YARLI

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.By similarity

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    Pathwayi

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Alpha-1,2-mannosyltransferase ALG11
    Asparagine-linked glycosylation protein 11
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:ALG11
    Ordered Locus Names:YALI0D08558g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome D

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080279Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6C9T3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6C9T3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase group 1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    HOGENOMiHOG000209670.
    KOiK03844.
    OMAiHPYANNG.
    OrthoDBiEOG7673KQ.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6C9T3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALQLDLPTL HDLRVVLNAD FLAALAALLL LAVILVPLCS YISLYAWSAI    50
    LAFKLRSPPA NWEKSIVKGV QANGTSTLFG FGFWQAAAVR RQLILQSNDP 100
    SYYSVTHVSR RSEIAISPED RNTEFRNRAQ DSGAPRRVIY GFFHPYANAG 150
    GGGERVLWAA VKDTLMYDDN IICAIYCGEQ DLPTRTSPST VLDAAVSNFH 200
    VTELADKELR KRIVFIGMRG RRLVDPKTWP RFTLMMQAAG SVWMAWHGIS 250
    TLVPDVFVDT MGYPFAYPLV SWVTHVPVAA YVHYPVISKD MLATVSLKQS 300
    PVRAALAVAK LVYWRVFALT YTFAGSYCSV VMTNSSWTNN HMQHMWWYNH 350
    KAEHIKIVYP PCGTQALSEI AMSEETSARS PNIVYIAQFR PEKRHDIVLR 400
    EFNKFYKEYT EKYPNQPAPH LTFVGTVRND DDKSRVYLLR LQARDLVNPD 450
    SVSFVLDAPF DKVRDILRTA SMGVNAMWNE HFGIVVVEYM SAGLIPVVHN 500
    SGGPKCDIVV PYEGQSTGNS GTLSAMPSST SIRSHYEAVP PGPTGFHFNC 550
    PGSDPTTDSG PSYDGEPIGT LAETLMRAFE LSESDTHNMR ARARESVKKR 600
    FSNEQFGSHW QVRMRILEKL EQIRRGHRLT RGDFD 635
    Length:635
    Mass (Da):71,363
    Last modified:August 16, 2004 - v1
    Checksum:i50814E76F2CD6018
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382130 Genomic DNA. Translation: CAG80767.1.
    RefSeqiXP_502579.1. XM_502579.1.

    Genome annotation databases

    EnsemblFungiiCAG80767; CAG80767; YALI0_D08558g.
    GeneIDi2910710.
    KEGGiyli:YALI0D08558g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382130 Genomic DNA. Translation: CAG80767.1 .
    RefSeqi XP_502579.1. XM_502579.1.

    3D structure databases

    ProteinModelPortali Q6C9T3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6C9T3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG80767 ; CAG80767 ; YALI0_D08558g .
    GeneIDi 2910710.
    KEGGi yli:YALI0D08558g.

    Phylogenomic databases

    eggNOGi COG0438.
    HOGENOMi HOG000209670.
    KOi K03844.
    OMAi HPYANNG.
    OrthoDBi EOG7673KQ.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiALG11_YARLI
    AccessioniPrimary (citable) accession number: Q6C9T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3