Reviewed, UniProtKB/Swiss-Prot Q6C9M8 (KMO_YARLI)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase
    Biosynthesis of nicotinic acid protein 4

Gene names

Name:	BNA4
Ordered Locus Names:	YALI0D09867g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Mitochondrion
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Kynurenine 3-monooxygenase		PRO_0000361934

Sequences

	Sequence		Length	Mass (Da)
	Q6C9M8-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 59AE20C58A92CE4E	FASTA	463	52,387
	10 20 30 40 50 60 MHEVTVVGAG LVGCLAALAF ADRGHKVALY DARPDLRSEA ELKNASLRSI NLAVSARGIE 70 80 90 100 110 120 ALRSVDTKMA ERVLADIIPM YGRMIHDLQG GQHAQAYGLW GECINSIDRA QLNRTMLDVI 130 140 150 160 170 180 EDNANITFFP EHKLTNISLS RKDKKYQRPT STFETKEGEE RVVESDYIIG ADGAFSKTRD 190 200 210 220 230 240 RLQRYVRMNY AQQYIDCVYL ELKIPKADGP DPFSISPNHL HIWPRHKYML IALANGDGSF 250 260 270 280 290 300 TSTLFAPPAL MEQVCESQNT FISFFKEQFP DAYELMGESQ ILESYENNPR SPLVSLKCSP 310 320 330 340 350 360 YNHKGECLLV GDAAHCMVPF YGQGMNAGFE DIRVLMEILD EKKWNVEEAF NTYTERRHKD 370 380 390 400 410 420 LVAIVDLAMR NYVEMSHSVV SLPYLIRKKV DGVLGRVFSS AWVPLYSMVS FRADIPYSKA 430 440 450 460 LSRSARQDRI IGNIVNWTSF AGLVGMGALF YYKGRHLFGR LFE

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382130 Genomic DNA. Translation: CAG80822.1.
RefSeq	XP_502634.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6C9M8.
Genome annotation databases
GeneID	2910925.
GenomeReviews	Gene locus YALI0D09867g in contig CR382130_GR.
KEGG	yli:YALI0D09867g.
Phylogenomic databases
HOGENOM	Q6C9M8.
OMA	LHAIMPS.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_YARLI

Accession

Primary (citable) accession number: Q6C9M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)