Q6C997 (LCMT1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine carboxyl methyltransferase 1
EC=2.1.1.233

Alternative name(s):
Protein phosphatase methyltransferase 1
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

Gene names

Name:	PPM1
Ordered Locus Names:	YALI0D12881g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia › Yarrowia lipolytica

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues By similarity.
Catalytic activity	S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
Sequence similarities	Belongs to the methyltransferase superfamily. LCMT family.

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Leucine carboxyl methyltransferase 1		PRO_0000226134
Regions
	Region	172 – 173	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	74	1	S-adenosyl-L-methionine By similarity
	Binding site	101	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	128	1	S-adenosyl-L-methionine By similarity
	Binding site	196	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6C997 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 8929CEDB915D76A6	FASTA	324	36,463
	10 20 30 40 50 60 MNLRKDKVVQ STDGDALSSK YSAVQKGYLQ DEFIDLFVAG SKQAAAQQGP GSARKVVAQF 70 80 90 100 110 120 QPKLPLINRG TFVRHHAIDV LVDRFLAAKK PGQRVQIISL GAGSDTRPFS LWSSKPENRD 130 140 150 160 170 180 EILYHEIDFA VSVERKRDII MQDSTLRELV GAQEYDKTTG MHTQRYHLHG IDLRSIGPGF 190 200 210 220 230 240 VLPGSDPSLA TLIISECCLC YLEPDQAKQV IFWITSEFTN STIVMYEPLS GQDQFGQVMI 250 260 270 280 290 300 ENLASRGISI PSMTKFPSLE SQIERFKAAG YTEVLATSMD VIHDEWLSPE EQQRIHGLEF 310 320 LDEREELLLL LKHYCVVWAS NLTK

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382130 Genomic DNA. Translation: CAG80953.1.
RefSeq	XP_502765.1. XM_502765.1.
3D structure databases
ProteinModelPortal	Q6C997.
ModBase	Search...
Protein-protein interaction databases
STRING	4952.Q6C997.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2911265.
KEGG	yli:YALI0D12881g.
Phylogenomic databases
eggNOG	NOG329644.
HOGENOM	HOG000205368.
OMA	ECVLVYI.
OrthoDB	EOG4ZW8MC.
Family and domain databases
InterPro	IPR007213. LCM_MeTrfase. IPR021121. LCM_MeTrfase_euk. IPR016651. Leu_CO_MeTrfase_LCTM1. [Graphical view]
PANTHER	PTHR13600. PTHR13600. 1 hit.
Pfam	PF04072. LCM. 1 hit. [Graphical view]
PIRSF	PIRSF016305. LCM_mtfrase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LCMT1_YARLI

Accession

Primary (citable) accession number: Q6C997

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program