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Q6C8A3

- DNLI4_YARLI

UniProt

Q6C8A3 - DNLI4_YARLI

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Protein
DNA ligase 4
Gene
LIG4, YALI0D21384g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining By similarity.

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei307 – 3071ATP By similarity
Active sitei309 – 3091N6-AMP-lysine intermediate By similarity
Binding sitei314 – 3141ATP By similarity
Binding sitei331 – 3311ATP By similarity
Metal bindingi371 – 3711Magnesium 1 Reviewed prediction
Metal bindingi476 – 4761Magnesium 2 Reviewed prediction
Binding sitei481 – 4811ATP By similarity
Binding sitei492 – 4921ATP By similarity
Binding sitei498 – 4981ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 4 (EC:6.5.1.1)
Alternative name(s):
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene namesi
Name:LIG4
Ordered Locus Names:YALI0D21384g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome D

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956DNA ligase 4
PRO_0000278386Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6C8A3.

Structurei

3D structure databases

ProteinModelPortaliQ6C8A3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini700 – 79394BRCT 1
Add
BLAST
Domaini857 – 956100BRCT 2
Add
BLAST

Sequence similaritiesi

Contains 2 BRCT domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000176213.
KOiK10777.
OMAiKMDGDRM.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C8A3-1 [UniParc]FASTAAdd to Basket

« Hide

MSSERRPELE ETAVDPATGS AASRKFSIVQ DAVETTIVAP TNHGPSPRFS    50
TLVRNLFEPL VNLSAVVAAL RKKPTEAKAH IASQFIKGWV EEVGKDIYPA 100
FRLILPDKDR ERAVYGLKEK ALGRLWVKVL NLAKDSPDAK ALSEWKQGGN 150
ESAGNFSKRC YEVLSKRTSL TDYGHMTVDE VNERLDLLAD GETDQAKQIE 200
ILTYFYKHMN ATELKWLVNI ILRQMKMNAT EKVFFEPWHP DAESLFNVTA 250
SLKRVCWELT DPTKRLTSAE AQVSLFACFM PQIAAFPKYS GQDIAGKHFK 300
GRPFYIEEKI DGERMQMHMS EYGNKFHWWS RRSKDFTETY GNSLDDASGS 350
LTKRLRGIIN PKVRNCVLDG EMVAYDPATK KIIPFGTLRT ANRNEQNDLN 400
LTKPMFMVFD ILLLNDKPLV DYTLAERKRT LRTIFARTDN ETVGQEGVLE 450
VLPYTEATTA AEIETCMRKI IAESSEGLVI KDPTSVYRVN TRDDSWLKMK 500
PEYMSEFGEK LDVVIIGGYY GSGKRGSILS SYLCGLRADG SDQFWSFFKV 550
GGGLTAGDYQ AIRTKTEGKW KRWDKNDKPK NVLLAGPNGD LERPDVWIEP 600
SDSVVVEVKA ASVVASDQYK VGLCLRFPRF RALRLDKTWE DGLTISQFAE 650
LRQTVEMEAE NKELELEDRK RRNAGPGRGA KRLKLANVSS DEDELGTDER 700
PTSVFKATSF AVLSDMSSPR YMSKAAVENL IKKHGGTVFQ TVEGPHTIPV 750
ADTRTIKVQA LTKRVHGVDV IRPNWLLDCI NEEKLVALEP RNLLESSAET 800
LALAKTNVDE FGDSYTRPLT YKEMQEVLRF MDQFDLDQTN PPDLMMEVLE 850
TNDGAVPKGM LFYGKKVYMS TSNMDTVALE TQFRAYDALR CLQFGGANLV 900
TDMKDLVVAV AKTEEEAKEL RRVSSEQVFP FRVVSIKWVE ESWKNGTVEI 950
EDDYPL 956
Length:956
Mass (Da):108,061
Last modified:August 16, 2004 - v1
Checksum:i5169CFB807F4183B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG81303.1.
RefSeqiXP_503109.1. XM_503109.1.

Genome annotation databases

EnsemblFungiiCAG81303; CAG81303; YALI0_D21384g.
GeneIDi2911076.
KEGGiyli:YALI0D21384g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG81303.1 .
RefSeqi XP_503109.1. XM_503109.1.

3D structure databases

ProteinModelPortali Q6C8A3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C8A3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG81303 ; CAG81303 ; YALI0_D21384g .
GeneIDi 2911076.
KEGGi yli:YALI0D21384g.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000176213.
KOi K10777.
OMAi KMDGDRM.
OrthoDBi EOG7QC84G.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiDNLI4_YARLI
AccessioniPrimary (citable) accession number: Q6C8A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3