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Q6C842

- BUR1_YARLI

UniProt

Q6C842 - BUR1_YARLI

Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671ATPPROSITE-ProRule annotation
    Active sitei168 – 1681Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 529ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:BUR1
    Ordered Locus Names:YALI0D22935g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome D

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Serine/threonine-protein kinase BUR1PRO_0000085686Add
    BLAST

    Proteomic databases

    PRIDEiQ6C842.

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6C842.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6C842.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 339302Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi377 – 658282Pro-richAdd
    BLAST
    Compositional biasi387 – 706320Arg-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK15562.
    OMAiDYPPRER.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6C842-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHGQPHQHLH TSPTAPFNMT IPYQPSTYYG CSNVTESYKP LGKIGEGTFG    50
    EVFRAEQITT KRHVALKKIL LHSEKEGFPV TALREIRILK LLRHENVIPL 100
    VDLAVERGDQ SKKERGCVYM VTPYMDHDLA GLLGNQSVQL SPAHIKCYML 150
    QLLEGIGYLH AKKFLHRDIK AANILVNDQG ILKLADFGLA RGYDGPAPNS 200
    QTAGVNTENL TAMVVTRWYR PPELILGDRK YTTAIDMWGI GCVFGEFFTR 250
    KPIFPGASDV DQGSKIFQAV GVPTEDTMPG WSVLPGAQNS NIWGTDATNK 300
    LDKLFGRLSK DGLDFLKGLL LLDPTKRLTA IGGKNHAYFK TEPLPCQPHE 350
    LPKWQSSHEL DNHKRREQEK NESKVQPPPR EKQPPVREPR DRDRSRDSRP 400
    PRERDSRDRR PPRGRYDSFE RPERRPEGPR DGPRDRDRDE YPRELPPRDL 450
    PPRDLPPRDR DYPPRERDWD RRPPPRDRDY PPRERDYPPR DSRDRDYHPR 500
    DRDYPPRDSR DYPRDSRDSR DSRPISPSRE RFHKRPQFDM YSDTDYDRER 550
    DEDDRRRRPL PRDSSRDMTR DVYVPSRGRE PRELPKGPPP APGDKVEDKG 600
    ESHNKDDKPC DTENPRDSDK SRDLGPPPGP PLPADGPPPP PSSNPPRPSE 650
    TYGGSRPPWR RDSRDRRESR DRDGRDRDGR DRRLSSSRYA RDEFDEYGRK 700
    RPRIER 706
    Length:706
    Mass (Da):81,855
    Last modified:August 16, 2004 - v1
    Checksum:i02C0A7D4A80049D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382130 Genomic DNA. Translation: CAG81370.1.
    RefSeqiXP_503170.1. XM_503170.1.

    Genome annotation databases

    EnsemblFungiiCAG81370; CAG81370; YALI0_D22935g.
    GeneIDi2911247.
    KEGGiyli:YALI0D22935g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382130 Genomic DNA. Translation: CAG81370.1 .
    RefSeqi XP_503170.1. XM_503170.1.

    3D structure databases

    ProteinModelPortali Q6C842.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6C842.

    Proteomic databases

    PRIDEi Q6C842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG81370 ; CAG81370 ; YALI0_D22935g .
    GeneIDi 2911247.
    KEGGi yli:YALI0D22935g.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K15562.
    OMAi DYPPRER.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiBUR1_YARLI
    AccessioniPrimary (citable) accession number: Q6C842
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3