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Q6C842

- BUR1_YARLI

UniProt

Q6C842 - BUR1_YARLI

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Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671ATPPROSITE-ProRule annotation
Active sitei168 – 1681Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 529ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:BUR1
Ordered Locus Names:YALI0D22935g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome D

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Serine/threonine-protein kinase BUR1PRO_0000085686Add
BLAST

Proteomic databases

PRIDEiQ6C842.

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6C842.

Structurei

3D structure databases

ProteinModelPortaliQ6C842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 339302Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi377 – 658282Pro-richAdd
BLAST
Compositional biasi387 – 706320Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6C842.
KOiK15562.
OMAiDYPPRER.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C842-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGQPHQHLH TSPTAPFNMT IPYQPSTYYG CSNVTESYKP LGKIGEGTFG
60 70 80 90 100
EVFRAEQITT KRHVALKKIL LHSEKEGFPV TALREIRILK LLRHENVIPL
110 120 130 140 150
VDLAVERGDQ SKKERGCVYM VTPYMDHDLA GLLGNQSVQL SPAHIKCYML
160 170 180 190 200
QLLEGIGYLH AKKFLHRDIK AANILVNDQG ILKLADFGLA RGYDGPAPNS
210 220 230 240 250
QTAGVNTENL TAMVVTRWYR PPELILGDRK YTTAIDMWGI GCVFGEFFTR
260 270 280 290 300
KPIFPGASDV DQGSKIFQAV GVPTEDTMPG WSVLPGAQNS NIWGTDATNK
310 320 330 340 350
LDKLFGRLSK DGLDFLKGLL LLDPTKRLTA IGGKNHAYFK TEPLPCQPHE
360 370 380 390 400
LPKWQSSHEL DNHKRREQEK NESKVQPPPR EKQPPVREPR DRDRSRDSRP
410 420 430 440 450
PRERDSRDRR PPRGRYDSFE RPERRPEGPR DGPRDRDRDE YPRELPPRDL
460 470 480 490 500
PPRDLPPRDR DYPPRERDWD RRPPPRDRDY PPRERDYPPR DSRDRDYHPR
510 520 530 540 550
DRDYPPRDSR DYPRDSRDSR DSRPISPSRE RFHKRPQFDM YSDTDYDRER
560 570 580 590 600
DEDDRRRRPL PRDSSRDMTR DVYVPSRGRE PRELPKGPPP APGDKVEDKG
610 620 630 640 650
ESHNKDDKPC DTENPRDSDK SRDLGPPPGP PLPADGPPPP PSSNPPRPSE
660 670 680 690 700
TYGGSRPPWR RDSRDRRESR DRDGRDRDGR DRRLSSSRYA RDEFDEYGRK

RPRIER
Length:706
Mass (Da):81,855
Last modified:August 16, 2004 - v1
Checksum:i02C0A7D4A80049D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA. Translation: CAG81370.1.
RefSeqiXP_503170.1. XM_503170.1.

Genome annotation databases

EnsemblFungiiCAG81370; CAG81370; YALI0_D22935g.
GeneIDi2911247.
KEGGiyli:YALI0D22935g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA. Translation: CAG81370.1 .
RefSeqi XP_503170.1. XM_503170.1.

3D structure databases

ProteinModelPortali Q6C842.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C842.

Proteomic databases

PRIDEi Q6C842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG81370 ; CAG81370 ; YALI0_D22935g .
GeneIDi 2911247.
KEGGi yli:YALI0D22935g.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q6C842.
KOi K15562.
OMAi DYPPRER.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiBUR1_YARLI
AccessioniPrimary (citable) accession number: Q6C842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3