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Q6C842

- BUR1_YARLI

UniProt

Q6C842 - BUR1_YARLI

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Protein
Serine/threonine-protein kinase BUR1
Gene
BUR1, YALI0D22935g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671ATP By similarity
Active sitei168 – 1681Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 529ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:BUR1
Ordered Locus Names:YALI0D22935g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome D

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Serine/threonine-protein kinase BUR1
PRO_0000085686Add
BLAST

Proteomic databases

PRIDEiQ6C842.

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6C842.

Structurei

3D structure databases

ProteinModelPortaliQ6C842.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 339302Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi377 – 658282Pro-rich
Add
BLAST
Compositional biasi387 – 706320Arg-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK15562.
OMAiDYPPRER.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C842-1 [UniParc]FASTAAdd to Basket

« Hide

MHGQPHQHLH TSPTAPFNMT IPYQPSTYYG CSNVTESYKP LGKIGEGTFG    50
EVFRAEQITT KRHVALKKIL LHSEKEGFPV TALREIRILK LLRHENVIPL 100
VDLAVERGDQ SKKERGCVYM VTPYMDHDLA GLLGNQSVQL SPAHIKCYML 150
QLLEGIGYLH AKKFLHRDIK AANILVNDQG ILKLADFGLA RGYDGPAPNS 200
QTAGVNTENL TAMVVTRWYR PPELILGDRK YTTAIDMWGI GCVFGEFFTR 250
KPIFPGASDV DQGSKIFQAV GVPTEDTMPG WSVLPGAQNS NIWGTDATNK 300
LDKLFGRLSK DGLDFLKGLL LLDPTKRLTA IGGKNHAYFK TEPLPCQPHE 350
LPKWQSSHEL DNHKRREQEK NESKVQPPPR EKQPPVREPR DRDRSRDSRP 400
PRERDSRDRR PPRGRYDSFE RPERRPEGPR DGPRDRDRDE YPRELPPRDL 450
PPRDLPPRDR DYPPRERDWD RRPPPRDRDY PPRERDYPPR DSRDRDYHPR 500
DRDYPPRDSR DYPRDSRDSR DSRPISPSRE RFHKRPQFDM YSDTDYDRER 550
DEDDRRRRPL PRDSSRDMTR DVYVPSRGRE PRELPKGPPP APGDKVEDKG 600
ESHNKDDKPC DTENPRDSDK SRDLGPPPGP PLPADGPPPP PSSNPPRPSE 650
TYGGSRPPWR RDSRDRRESR DRDGRDRDGR DRRLSSSRYA RDEFDEYGRK 700
RPRIER 706
Length:706
Mass (Da):81,855
Last modified:August 16, 2004 - v1
Checksum:i02C0A7D4A80049D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG81370.1.
RefSeqiXP_503170.1. XM_503170.1.

Genome annotation databases

EnsemblFungiiCAG81370; CAG81370; YALI0_D22935g.
GeneIDi2911247.
KEGGiyli:YALI0D22935g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG81370.1 .
RefSeqi XP_503170.1. XM_503170.1.

3D structure databases

ProteinModelPortali Q6C842.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C842.

Proteomic databases

PRIDEi Q6C842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG81370 ; CAG81370 ; YALI0_D22935g .
GeneIDi 2911247.
KEGGi yli:YALI0D22935g.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K15562.
OMAi DYPPRER.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiBUR1_YARLI
AccessioniPrimary (citable) accession number: Q6C842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3