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Q6C842 (BUR1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase BUR1

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:BUR1
Ordered Locus Names:YALI0D22935g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length706 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 706706Serine/threonine-protein kinase BUR1
PRO_0000085686

Regions

Domain38 – 339302Protein kinase
Nucleotide binding44 – 529ATP By similarity
Compositional bias377 – 658282Pro-rich
Compositional bias387 – 706320Arg-rich

Sites

Active site1681Proton acceptor By similarity
Binding site671ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6C842 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 02C0A7D4A80049D2

FASTA70681,855
        10         20         30         40         50         60 
MHGQPHQHLH TSPTAPFNMT IPYQPSTYYG CSNVTESYKP LGKIGEGTFG EVFRAEQITT 

        70         80         90        100        110        120 
KRHVALKKIL LHSEKEGFPV TALREIRILK LLRHENVIPL VDLAVERGDQ SKKERGCVYM 

       130        140        150        160        170        180 
VTPYMDHDLA GLLGNQSVQL SPAHIKCYML QLLEGIGYLH AKKFLHRDIK AANILVNDQG 

       190        200        210        220        230        240 
ILKLADFGLA RGYDGPAPNS QTAGVNTENL TAMVVTRWYR PPELILGDRK YTTAIDMWGI 

       250        260        270        280        290        300 
GCVFGEFFTR KPIFPGASDV DQGSKIFQAV GVPTEDTMPG WSVLPGAQNS NIWGTDATNK 

       310        320        330        340        350        360 
LDKLFGRLSK DGLDFLKGLL LLDPTKRLTA IGGKNHAYFK TEPLPCQPHE LPKWQSSHEL 

       370        380        390        400        410        420 
DNHKRREQEK NESKVQPPPR EKQPPVREPR DRDRSRDSRP PRERDSRDRR PPRGRYDSFE 

       430        440        450        460        470        480 
RPERRPEGPR DGPRDRDRDE YPRELPPRDL PPRDLPPRDR DYPPRERDWD RRPPPRDRDY 

       490        500        510        520        530        540 
PPRERDYPPR DSRDRDYHPR DRDYPPRDSR DYPRDSRDSR DSRPISPSRE RFHKRPQFDM 

       550        560        570        580        590        600 
YSDTDYDRER DEDDRRRRPL PRDSSRDMTR DVYVPSRGRE PRELPKGPPP APGDKVEDKG 

       610        620        630        640        650        660 
ESHNKDDKPC DTENPRDSDK SRDLGPPPGP PLPADGPPPP PSSNPPRPSE TYGGSRPPWR 

       670        680        690        700 
RDSRDRRESR DRDGRDRDGR DRRLSSSRYA RDEFDEYGRK RPRIER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382130 Genomic DNA. Translation: CAG81370.1.
RefSeqXP_503170.1. XM_503170.1.

3D structure databases

ProteinModelPortalQ6C842.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C842.

Proteomic databases

PRIDEQ6C842.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG81370; CAG81370; YALI0_D22935g.
GeneID2911247.
KEGGyli:YALI0D22935g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK15562.
OMADYPPRER.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_YARLI
AccessionPrimary (citable) accession number: Q6C842
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families