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Protein

ATP-dependent RNA helicase DBP10

Gene

DBP10

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi146 – 153ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DBP10 (EC:3.6.4.13)
Gene namesi
Name:DBP10
Ordered Locus Names:YALI0D24497g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome D

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002323201 – 926ATP-dependent RNA helicase DBP10Add BLAST926

Proteomic databases

PRIDEiQ6C7X8.

Structurei

3D structure databases

ProteinModelPortaliQ6C7X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 305Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST173
Domaini370 – 529Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi102 – 130Q motifAdd BLAST29
Motifi253 – 256DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi910 – 925Gly-richAdd BLAST16

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000246455.
InParanoidiQ6C7X8.
KOiK14808.
OMAiGWAYSIV.
OrthoDBiEOG092C1VLP.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR012541. DBP10_C.
IPR033517. DDX54/DBP10.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF292. PTHR24031:SF292. 4 hits.
PfamiPF08147. DBP10CT. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
ProDomiPD024971. DBP10CT. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01123. DBP10CT. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C7X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSEVEYDI AGSLNPGVDS EDDYSSGSES DSEIPDIIED SEDETGPQQG
60 70 80 90 100
EPGTMTFPNL ELSDDDDDDD DDDEGRKKKK KKTDDSVESY FGAPQTGKKS
110 120 130 140 150
SGSFAGLGLS QLVLKNIARK GFKQPTPIQR KTIPLVLEGK DVVGMARTGS
160 170 180 190 200
GKTAAFVLPM LEKLKVHSAK VGARAVILSP SRELALQTLK VVKDFSAGTD
210 220 230 240 250
LRLAMLVGGD SLEEQFKMMM SNPDIIIATP GRFLHLKVEM ELSLASVEYI
260 270 280 290 300
CFDEADRLFE LGFGEQMNEL LASLPSNRQT LLFSATLPKT LVEFAKAGLH
310 320 330 340 350
DPILVRLDAE TKLPEHLEMT FFAVKENQRD ACLAFILKEV IQMPFATPEQ
360 370 380 390 400
LKELERLDER AIDDGERDED RKQKRPKFKK ERLPPAHQLP SEKSTIVFCP
410 420 430 440 450
TKHHVEYVIV LLQTLGYAVS YIYGTLDQHA RKNQLYRFRT GKTSILVVTD
460 470 480 490 500
VAARGIDVPV LANVINYSLP PSPKVFIHRV GRTARAGNRG WAYSIIKDND
510 520 530 540 550
IPYLLDLEVF LGRKLLTPRL FKQQNPDPSA EPDYVNTLTI GAPPRQALEI
560 570 580 590 600
HGEELAQMVK DSYELQQLSE VAVKGERMYN KTKGSASQES AKRSKQIMAL
610 620 630 640 650
GWDDHHLMFG EDGESAKDAL LARLGQKRIR ETVFEFRKSK TTSGAEMMAT
660 670 680 690 700
RRAQLAPIQR RAAEKRAIQE KERLAGLVHS QDAEIARSTE EDMATEADLT
710 720 730 740 750
GFTTEEDLRA AKKAQKSKKR SFRDSENFMS HYAPTNDDKG YAVGNFAGAA
760 770 780 790 800
SNATFDLIND GSEMQQKQGM KWDKKKGKFI NAGSEGGKKF IRGEGGQRIA
810 820 830 840 850
ASFRSGRFDK WKAAHKVGNL KVGALEESGP ATKRVLSARE FKHNKNEAPK
860 870 880 890 900
RADKYRDDFH KQKTKVAAAK EDGRIQKPQP KSELKSTADV RKSRILAEKR
910 920
KQKNARPSRG GRGGGRGGRG GGRGGR
Length:926
Mass (Da):102,850
Last modified:August 16, 2004 - v1
Checksum:i1FEC413E60789D53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA. Translation: CAG81435.1.
RefSeqiXP_503234.1. XM_503234.1.

Genome annotation databases

EnsemblFungiiCAG81435; CAG81435; YALI0_D24497g.
GeneIDi2910446.
KEGGiyli:YALI0D24497g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA. Translation: CAG81435.1.
RefSeqiXP_503234.1. XM_503234.1.

3D structure databases

ProteinModelPortaliQ6C7X8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6C7X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG81435; CAG81435; YALI0_D24497g.
GeneIDi2910446.
KEGGiyli:YALI0D24497g.

Phylogenomic databases

HOGENOMiHOG000246455.
InParanoidiQ6C7X8.
KOiK14808.
OMAiGWAYSIV.
OrthoDBiEOG092C1VLP.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR012541. DBP10_C.
IPR033517. DDX54/DBP10.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF292. PTHR24031:SF292. 4 hits.
PfamiPF08147. DBP10CT. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
ProDomiPD024971. DBP10CT. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01123. DBP10CT. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBP10_YARLI
AccessioniPrimary (citable) accession number: Q6C7X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: October 5, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.