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Q6C7U8

- PHO85_YARLI

UniProt

Q6C7U8 - PHO85_YARLI

Protein

Negative regulator of the PHO system

Gene

PHO85

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361ATPPROSITE-ProRule annotation
    Active sitei130 – 1301Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 219ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Negative regulator of the PHO system (EC:2.7.11.22)
    Alternative name(s):
    Serine/threonine-protein kinase PHO85
    Gene namesi
    Name:PHO85
    Ordered Locus Names:YALI0D25190g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome D

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Negative regulator of the PHO systemPRO_0000086520Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with a number of cyclins.By similarity

    Protein-protein interaction databases

    STRINGi4952.Q6C7U8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6C7U8.
    SMRiQ6C7U8. Positions 7-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 289283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK06655.
    OMAiQVPQNAY.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6C7U8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTSSQFQQL EKLGEGTYAT VYKGRNRTTG QLVALKEINL DSEEGTPSTA    50
    IREISLMKEL KHENIVTLYD VIHTENKLNL VFEYMDKDLK KFMDTNGNKG 100
    ALETKQVKWF MYQLLRGILF CHDNRVLHRD LKPQNLLINA KGQLKLADFG 150
    LARAFGIPVN TFSNEVVTLW YRAPDVLLGS RTYSTSIDIW SAGCIMAEMF 200
    TGRPLFPGSS NDDQLQHIFK LMGTPNESTW PNISSLPNYR SNFQVYAPQD 250
    LRVIIPQIDN VALDLLLSLL QLKPENRITA RQSLEHPWFA EYHQ 294
    Length:294
    Mass (Da):33,671
    Last modified:August 16, 2004 - v1
    Checksum:i5764A684447E6C79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382130 Genomic DNA. Translation: CAG81468.1.
    RefSeqiXP_503264.1. XM_503264.1.

    Genome annotation databases

    EnsemblFungiiCAG81468; CAG81468; YALI0_D25190g.
    GeneIDi2910782.
    KEGGiyli:YALI0D25190g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382130 Genomic DNA. Translation: CAG81468.1 .
    RefSeqi XP_503264.1. XM_503264.1.

    3D structure databases

    ProteinModelPortali Q6C7U8.
    SMRi Q6C7U8. Positions 7-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6C7U8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG81468 ; CAG81468 ; YALI0_D25190g .
    GeneIDi 2910782.
    KEGGi yli:YALI0D25190g.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K06655.
    OMAi QVPQNAY.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiPHO85_YARLI
    AccessioniPrimary (citable) accession number: Q6C7U8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3