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Q6C7U8

- PHO85_YARLI

UniProt

Q6C7U8 - PHO85_YARLI

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Protein

Negative regulator of the PHO system

Gene
PHO85, YALI0D25190g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361ATP By similarity
Active sitei130 – 1301Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of the PHO system (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene namesi
Name:PHO85
Ordered Locus Names:YALI0D25190g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome D

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Negative regulator of the PHO systemPRO_0000086520Add
BLAST

Interactioni

Subunit structurei

Interacts with a number of cyclins By similarity.

Protein-protein interaction databases

STRINGi4952.Q6C7U8.

Structurei

3D structure databases

ProteinModelPortaliQ6C7U8.
SMRiQ6C7U8. Positions 7-293.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 289283Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK06655.
OMAiQVPQNAY.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C7U8-1 [UniParc]FASTAAdd to Basket

« Hide

MNTSSQFQQL EKLGEGTYAT VYKGRNRTTG QLVALKEINL DSEEGTPSTA    50
IREISLMKEL KHENIVTLYD VIHTENKLNL VFEYMDKDLK KFMDTNGNKG 100
ALETKQVKWF MYQLLRGILF CHDNRVLHRD LKPQNLLINA KGQLKLADFG 150
LARAFGIPVN TFSNEVVTLW YRAPDVLLGS RTYSTSIDIW SAGCIMAEMF 200
TGRPLFPGSS NDDQLQHIFK LMGTPNESTW PNISSLPNYR SNFQVYAPQD 250
LRVIIPQIDN VALDLLLSLL QLKPENRITA RQSLEHPWFA EYHQ 294
Length:294
Mass (Da):33,671
Last modified:August 16, 2004 - v1
Checksum:i5764A684447E6C79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG81468.1.
RefSeqiXP_503264.1. XM_503264.1.

Genome annotation databases

EnsemblFungiiCAG81468; CAG81468; YALI0_D25190g.
GeneIDi2910782.
KEGGiyli:YALI0D25190g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382130 Genomic DNA. Translation: CAG81468.1 .
RefSeqi XP_503264.1. XM_503264.1.

3D structure databases

ProteinModelPortali Q6C7U8.
SMRi Q6C7U8. Positions 7-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C7U8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG81468 ; CAG81468 ; YALI0_D25190g .
GeneIDi 2910782.
KEGGi yli:YALI0D25190g.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K06655.
OMAi QVPQNAY.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPHO85_YARLI
AccessioniPrimary (citable) accession number: Q6C7U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi