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Protein

Negative regulator of the PHO system

Gene

PHO85

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36ATPPROSITE-ProRule annotation1
Active sitei130Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of the PHO system (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene namesi
Name:PHO85
Ordered Locus Names:YALI0D25190g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865201 – 294Negative regulator of the PHO systemAdd BLAST294

Proteomic databases

PRIDEiQ6C7U8

Interactioni

Subunit structurei

Interacts with a number of cyclins.By similarity

Protein-protein interaction databases

STRINGi4952.XP_503264.1

Structurei

3D structure databases

ProteinModelPortaliQ6C7U8
SMRiQ6C7U8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ6C7U8
KOiK06655
OMAiRHTNETI
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q6C7U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSSQFQQL EKLGEGTYAT VYKGRNRTTG QLVALKEINL DSEEGTPSTA
60 70 80 90 100
IREISLMKEL KHENIVTLYD VIHTENKLNL VFEYMDKDLK KFMDTNGNKG
110 120 130 140 150
ALETKQVKWF MYQLLRGILF CHDNRVLHRD LKPQNLLINA KGQLKLADFG
160 170 180 190 200
LARAFGIPVN TFSNEVVTLW YRAPDVLLGS RTYSTSIDIW SAGCIMAEMF
210 220 230 240 250
TGRPLFPGSS NDDQLQHIFK LMGTPNESTW PNISSLPNYR SNFQVYAPQD
260 270 280 290
LRVIIPQIDN VALDLLLSLL QLKPENRITA RQSLEHPWFA EYHQ
Length:294
Mass (Da):33,671
Last modified:August 16, 2004 - v1
Checksum:i5764A684447E6C79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA Translation: CAG81468.1
RefSeqiXP_503264.1, XM_503264.1

Genome annotation databases

EnsemblFungiiCAG81468; CAG81468; YALI0_D25190g
GeneIDi2910782
KEGGiyli:YALI0D25190g

Similar proteinsi

Entry informationi

Entry nameiPHO85_YARLI
AccessioniPrimary (citable) accession number: Q6C7U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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