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Q6C7U8 (PHO85_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Negative regulator of the PHO system

EC=2.7.11.22
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene names
Name:PHO85
Ordered Locus Names:YALI0D25190g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with a number of cyclins By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Negative regulator of the PHO system
PRO_0000086520

Regions

Domain7 – 289283Protein kinase
Nucleotide binding13 – 219ATP By similarity

Sites

Active site1301Proton acceptor By similarity
Binding site361ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6C7U8 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 5764A684447E6C79

FASTA29433,671
        10         20         30         40         50         60 
MNTSSQFQQL EKLGEGTYAT VYKGRNRTTG QLVALKEINL DSEEGTPSTA IREISLMKEL 

        70         80         90        100        110        120 
KHENIVTLYD VIHTENKLNL VFEYMDKDLK KFMDTNGNKG ALETKQVKWF MYQLLRGILF 

       130        140        150        160        170        180 
CHDNRVLHRD LKPQNLLINA KGQLKLADFG LARAFGIPVN TFSNEVVTLW YRAPDVLLGS 

       190        200        210        220        230        240 
RTYSTSIDIW SAGCIMAEMF TGRPLFPGSS NDDQLQHIFK LMGTPNESTW PNISSLPNYR 

       250        260        270        280        290 
SNFQVYAPQD LRVIIPQIDN VALDLLLSLL QLKPENRITA RQSLEHPWFA EYHQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382130 Genomic DNA. Translation: CAG81468.1.
RefSeqXP_503264.1. XM_503264.1.

3D structure databases

ProteinModelPortalQ6C7U8.
SMRQ6C7U8. Positions 7-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C7U8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG81468; CAG81468; YALI0_D25190g.
GeneID2910782.
KEGGyli:YALI0D25190g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK06655.
OMAQVPQNAY.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHO85_YARLI
AccessionPrimary (citable) accession number: Q6C7U8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families