Reviewed, UniProtKB/Swiss-Prot Q6C7U0 (ATG1_YARLI)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
Ordered Locus Names:	YALI0D25388g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	710 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 710	710	Serine/threonine-protein kinase ATG1		PRO_0000085654
Regions
	Domain	7 – 299	293	Protein kinase
	Nucleotide binding	13 – 21	9	ATP By similarity
Sites
	Active site	150	1	Proton acceptor By similarity
	Binding site	36	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6C7U0-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: EF075E8E10356ED6	FASTA	710	78,674
	10 20 30 40 50 60 MSSIKSYTIG NELGRGSFAT VYKGEHVASG SPVAIKSVLR AKLNRKLLEN LGSEISILKQ 70 80 90 100 110 120 MKHPHVVELL DFQETPTHFH LVMEYCSLGD LSFFLKKKKE LSETLPLVAS LLRRYPSNTR 130 140 150 160 170 180 GLHEELVRHF VHQLSAALEF LRQKNLVHRD IKPQNLLLCP PSLSEMDAQN ANLYGRWELP 190 200 210 220 230 240 ILKIADFGFA RILPASALAE TLCGSPLYMA PEILRYEKYN AKADLWSVGA VTYEMVVGKP 250 260 270 280 290 300 PFKANNYVEL LKTIEQSNDV IGFGREPPSE DMQDFVRCLL KKNPADRIGF KEYFEHPIIA 310 320 330 340 350 360 NKQVIGSGEE LDRSQLDPRM YISEYIQEAD LPKLDLDREM DSFSQKRSTQ KSSPKNSTNK 370 380 390 400 410 420 TLSSTVKNPL LELTSPSPGS SLLLTRKNES LFLESEYVVV EKRQVEVNTL ADELAREPDE 430 440 450 460 470 480 RRPSSERRFS LTYGAPTGAM ARALSMASAR LLGEKKNGAG HGSGNGSRNG SGNGSGNGAR 490 500 510 520 530 540 LSAGAALSGT SSGTSTTGKS PPVPATTTPS LSEREIVETL EEIAAKARSI ALLADVKYSQ 550 560 570 580 590 600 IQDDVDNPDM NLPDSVSSSI AEEAMLLYVK TLSLLSLAMD QAGAWWSNNH KDNKMVSSHF 610 620 630 640 650 660 NEIIQWTRSA FNESLERAET VKKKVSSGTT HTTAEKLIFD RALEMSRDAA VQEISGDFTG 670 680 690 700 710 CESAYTTSIW MLEALLEDDE DGLGEEDRRI VERFISSITK RLVILRGQQE

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382130 Genomic DNA. Translation: CAG81476.1.
RefSeq	XP_503272.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2910666.
KEGG	yli:YALI0D25388g.
Phylogenomic databases
HOGENOM	Q6C7U0.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_YARLI

Accession

Primary (citable) accession number: Q6C7U0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 16, 2004
Last modified:	November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)