Reviewed,
UniProtKB/Swiss-Prot Q6C710 (ESA1_YARLI)
Last modified
February 9, 2010.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase ESA1 EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Yarrowia lipolytica (Candida lipolytica) [Complete proteome] | ||||
| Taxonomic identifier | 4952 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia |
Protein attributes
| Sequence length | 469 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me By similarity. |
| Catalytic activity | Acetyl-CoA + [histone] = CoA + acetyl-[histone]. |
| Subunit structure | Component of the NuA4 histone acetyltransferase complex By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the MYST (SAS/MOZ) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Molecular function | Activator Chromatin regulator Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | chromatin assembly or disassembly Inferred from electronic annotation. Source: InterPro chromatin modificationInferred from electronic annotation. Source: UniProtKB-KW regulation of transcriptionInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chromatin Inferred from electronic annotation. Source: InterPro nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | chromatin binding Inferred from electronic annotation. Source: InterPro histone acetyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR382131 Genomic DNA. Translation: CAG79133.1. |
| RefSeq | XP_503552.1. |
3D structure databases | |
| SMR | Q6C710. Positions 32-106, 185-458. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6C710. |
Genome annotation databases | |
| GeneID | 2912208. |
| GenomeReviews | Gene locus YALI0E04675g in contig CR382131_GR. |
| KEGG | yli:YALI0E04675g. |
Phylogenomic databases | |
| eggNOG | fuNOG04749. |
| HOGENOM | HBG631736. |
| OMA | ILRYYKG. |
| OrthoDB | EOG9GF4XV. |
| PhylomeDB | Q6C710. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.48. 3602. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR000953. Chromodomain. IPR002717. MOZ_SAS. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| Pfam | PF01853. MOZ_SAS. 1 hit. [Graphical view] |
| SMART | SM00298. CHROMO. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ESA1_YARLI | ||||||||
| Accession | Primary (citable) accession number: Q6C710 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

Clusters with


