Reviewed, UniProtKB/Swiss-Prot Q6C710 (ESA1_YARLI)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase ESA1
    EC=2.3.1.48

Gene names

Name:	ESA1
Ordered Locus Names:	YALI0E04675g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subunit structure	Component of the NuA4 histone acetyltransferase complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the MYST (SAS/MOZ) family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator Chromatin regulator Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin assembly or disassembly Inferred from electronic annotation. Source: InterPro chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromatin Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chromatin binding Inferred from electronic annotation. Source: InterPro histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Histone acetyltransferase ESA1		PRO_0000051561
Regions
	Compositional bias	103 – 128	26	Lys-rich
Sites
	Active site	327	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6C710-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 50ABF9A067AD9140	FASTA	469	53,908
	10 20 30 40 50 60 MALAEADLPN GKTNGKASGS EETPAPVQKV DMNVAINELR VGCKVHVEKD GEDRVAEILS 70 80 90 100 110 120 VQMRRGNLEF YVHYVEFNKR LDERIAATRV DLSQGVIWPE PEKPKKPLSG AAKESSKEKK 130 140 150 160 170 180 KNPSKKQKLT DSAATTPGAN SEDVMDLDNL QVNGTTQDPD NFNRDEEIEK LRTGGSMTQS 190 200 210 220 230 240 SHEVARVRNL QRIVLGNHVI EPWYFSPYPI ELTEEDEIYI CDFTLCYFGS KKQFERFRSK 250 260 270 280 290 300 STLRHPPGNE IYRDEAVSFF EIDGRKQRTW CRNLCLLSKL FLDHKTLYYD VDPFLFYCMT 310 320 330 340 350 360 RRDEKGHHLV GYFSKEKESA EGYNVACILT LPQYQRHGYG RLLIDFSYAL SKAEGKTGSP 370 380 390 400 410 420 EKPLSDLGLL SYRAYWADTI IELLMEKGKQ EMTIEDIASV TAMTTTDVLH TLQTYNMLKY 430 440 450 460 YKGQHIICLT DSVCEKYEKM LKKRRRKVNS ELLKWKPPVF TAAQLRFAW

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382131 Genomic DNA. Translation: CAG79133.1.
RefSeq	XP_503552.1.
3D structure databases
SMR	Q6C710. Positions 32-106, 185-458.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6C710.
Genome annotation databases
GeneID	2912208.
GenomeReviews	Gene locus YALI0E04675g in contig CR382131_GR.
KEGG	yli:YALI0E04675g.
Phylogenomic databases
eggNOG	fuNOG04749.
HOGENOM	HBG631736.
OMA	ILRYYKG.
OrthoDB	EOG9GF4XV.
PhylomeDB	Q6C710.
Enzyme and pathway databases
BRENDA	2.3.1.48. 3602.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000953. Chromodomain. IPR002717. MOZ_SAS. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF01853. MOZ_SAS. 1 hit. [Graphical view]
SMART	SM00298. CHROMO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ESA1_YARLI

Accession

Primary (citable) accession number: Q6C710

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	August 16, 2004
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)