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Protein

Histone acetyltransferase ESA1

Gene

ESA1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei327Important for catalytic activityBy similarity1
Active sitei361Proton donor/acceptorBy similarity1
Binding sitei365Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 243C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase ESA1 (EC:2.3.1.48By similarity)
Gene namesi
Name:ESA1
Ordered Locus Names:YALI0E04675g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515611 – 469Histone acetyltransferase ESA1Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-285 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ6C710

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Protein-protein interaction databases

STRINGi4952.XP_503552.1

Structurei

3D structure databases

ProteinModelPortaliQ6C710
SMRiQ6C710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 457MYST-type HATPROSITE-ProRule annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 330Acetyl-CoA bindingBy similarity5
Regioni335 – 341Acetyl-CoA bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 128Lys-richAdd BLAST26

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 243C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Phylogenomic databases

HOGENOMiHOG000182457
InParanoidiQ6C710
KOiK11304
OMAiMNMVKYW
OrthoDBiEOG092C043Q

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR037995 Esa1/KAT5/Tip60
IPR002717 HAT_MYST-type
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR10615:SF124 PTHR10615:SF124, 1 hit
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6C710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAEADLPN GKTNGKASGS EETPAPVQKV DMNVAINELR VGCKVHVEKD
60 70 80 90 100
GEDRVAEILS VQMRRGNLEF YVHYVEFNKR LDERIAATRV DLSQGVIWPE
110 120 130 140 150
PEKPKKPLSG AAKESSKEKK KNPSKKQKLT DSAATTPGAN SEDVMDLDNL
160 170 180 190 200
QVNGTTQDPD NFNRDEEIEK LRTGGSMTQS SHEVARVRNL QRIVLGNHVI
210 220 230 240 250
EPWYFSPYPI ELTEEDEIYI CDFTLCYFGS KKQFERFRSK STLRHPPGNE
260 270 280 290 300
IYRDEAVSFF EIDGRKQRTW CRNLCLLSKL FLDHKTLYYD VDPFLFYCMT
310 320 330 340 350
RRDEKGHHLV GYFSKEKESA EGYNVACILT LPQYQRHGYG RLLIDFSYAL
360 370 380 390 400
SKAEGKTGSP EKPLSDLGLL SYRAYWADTI IELLMEKGKQ EMTIEDIASV
410 420 430 440 450
TAMTTTDVLH TLQTYNMLKY YKGQHIICLT DSVCEKYEKM LKKRRRKVNS
460
ELLKWKPPVF TAAQLRFAW
Length:469
Mass (Da):53,908
Last modified:August 16, 2004 - v1
Checksum:i50ABF9A067AD9140
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382131 Genomic DNA Translation: CAG79133.1
RefSeqiXP_503552.1, XM_503552.1

Genome annotation databases

EnsemblFungiiCAG79133; CAG79133; YALI0_E04675g
GeneIDi2912208
KEGGiyli:YALI0E04675g

Similar proteinsi

Entry informationi

Entry nameiESA1_YARLI
AccessioniPrimary (citable) accession number: Q6C710
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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