SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6C710

- ESA1_YARLI

UniProt

Q6C710 - ESA1_YARLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Histone acetyltransferase ESA1
Gene
ESA1, YALI0E04675g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei285 – 2851 By similarity
Active sitei327 – 3271Nucleophile By similarity
Binding sitei330 – 3301Acetyl-CoA By similarity
Binding sitei365 – 3651Acetyl-CoA By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase ESA1 (EC:2.3.1.48)
Gene namesi
Name:ESA1
Ordered Locus Names:YALI0E04675g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome E

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Histone acetyltransferase ESA1
PRO_0000051561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851N6-acetyllysine; by autocatalysis By similarity

Post-translational modificationi

Autoacetylation at Lys-285 is required for proper function By similarity.

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex By similarity.

Protein-protein interaction databases

STRINGi4952.Q6C710.

Structurei

3D structure databases

ProteinModelPortaliQ6C710.
SMRiQ6C710. Positions 185-458.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni335 – 3417Acetyl-CoA binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi103 – 12826Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.

Phylogenomic databases

eggNOGiCOG5027.
HOGENOMiHOG000182457.
KOiK11304.
OMAiEVEWPAP.
OrthoDBiEOG7RFTRR.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6C710-1 [UniParc]FASTAAdd to Basket

« Hide

MALAEADLPN GKTNGKASGS EETPAPVQKV DMNVAINELR VGCKVHVEKD    50
GEDRVAEILS VQMRRGNLEF YVHYVEFNKR LDERIAATRV DLSQGVIWPE 100
PEKPKKPLSG AAKESSKEKK KNPSKKQKLT DSAATTPGAN SEDVMDLDNL 150
QVNGTTQDPD NFNRDEEIEK LRTGGSMTQS SHEVARVRNL QRIVLGNHVI 200
EPWYFSPYPI ELTEEDEIYI CDFTLCYFGS KKQFERFRSK STLRHPPGNE 250
IYRDEAVSFF EIDGRKQRTW CRNLCLLSKL FLDHKTLYYD VDPFLFYCMT 300
RRDEKGHHLV GYFSKEKESA EGYNVACILT LPQYQRHGYG RLLIDFSYAL 350
SKAEGKTGSP EKPLSDLGLL SYRAYWADTI IELLMEKGKQ EMTIEDIASV 400
TAMTTTDVLH TLQTYNMLKY YKGQHIICLT DSVCEKYEKM LKKRRRKVNS 450
ELLKWKPPVF TAAQLRFAW 469
Length:469
Mass (Da):53,908
Last modified:August 16, 2004 - v1
Checksum:i50ABF9A067AD9140
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382131 Genomic DNA. Translation: CAG79133.1.
RefSeqiXP_503552.1. XM_503552.1.

Genome annotation databases

EnsemblFungiiCAG79133; CAG79133; YALI0_E04675g.
GeneIDi2912208.
KEGGiyli:YALI0E04675g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382131 Genomic DNA. Translation: CAG79133.1 .
RefSeqi XP_503552.1. XM_503552.1.

3D structure databases

ProteinModelPortali Q6C710.
SMRi Q6C710. Positions 185-458.
ModBasei Search...

Protein-protein interaction databases

STRINGi 4952.Q6C710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG79133 ; CAG79133 ; YALI0_E04675g .
GeneIDi 2912208.
KEGGi yli:YALI0E04675g.

Phylogenomic databases

eggNOGi COG5027.
HOGENOMi HOG000182457.
KOi K11304.
OMAi EVEWPAP.
OrthoDBi EOG7RFTRR.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view ]
Pfami PF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiESA1_YARLI
AccessioniPrimary (citable) accession number: Q6C710
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi