Q6C5P5 (Q6C5P5_YARLI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Serine hydroxymethyltransferase RuleBase RU000585
EC=2.1.2.1 RuleBase RU000585

Gene names

Ordered Locus Names:

YALI0E16346g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Interconversion of serine and glycine By similarity. RuleBase RU000585
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000585
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585
Sequence similarities	Belongs to the SHMT family. RuleBase RU004104

Ontologies

Keywords
Biological process	One-carbon metabolism RuleBase RU000585
Ligand	Pyridoxal phosphate RuleBase RU000585
Molecular function	Transferase RuleBase RU000585
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6C5P5 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 4042942E20A8CB66	FASTA	471	51,697
	10 20 30 40 50 60 MSSYALSNNH KDLIEASLHD LDPEVEGIMK DEIDRQKHSI VLIASENFTS KSVFDALGSP 70 80 90 100 110 120 MCNKYSEGYP GARYYGGNQH IDRIETLCQN RALKAFGVTP DKWGVNVQTL SGSPANLQVY 130 140 150 160 170 180 QAIMKPHDRL MGLDLPHGGH LSHGYQTDNR KISAVSTYFE TMPYRVDLET GIIDYDMLEK 190 200 210 220 230 240 TAILYRPKVL VAGTSAYCRL IDYKRMREIA DKVGAYLVVD MAHISGLIAA GVIPSPFEYA 250 260 270 280 290 300 DIVTTTTHKS LRGPRGAMIF FRRGVRSVDP KTGKEILYDL ENPINFSVFP GHQGGPHNHT 310 320 330 340 350 360 ITALAVALKQ AADPTFREYQ EQVLKNAKAL ETEFNKLGYN LVSGGTDSHM VLVSLRDKGI 370 380 390 400 410 420 DGARVETVCE QINIALNKNS IPGDKSALVP GGVRIGAPAM STRGFGEEDF KKIANYISQA 430 440 450 460 470 VDLAIEIQQG LPKEANKLKD FKAAAQAGGN PKIEALKTEI SNWAGQFPLP V

References

[1]

"Genome evolution in yeasts." Genolevures Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382131 Genomic DNA. Translation: CAG79610.1.
RefSeq	XP_504017.1. XM_504017.1.
3D structure databases
ProteinModelPortal	Q6C5P5.
SMR	Q6C5P5. Positions 5-470.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6C5P5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2911591.
GenomeReviews	Gene locus YALI0E16346g in contig CR382131_GR.
KEGG	yli:YALI0E16346g.
Phylogenomic databases
eggNOG	fuNOG04641.
HOGENOM	HBG301263.
OMA	GMILAKE.
OrthoDB	EOG444PTT.
Family and domain databases
HAMAP	MF_00051. SHMT. [Tree]
InterPro	IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00600.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6C5P5_YARLI

Accession

Primary (citable) accession number: Q6C5P5

Entry history

Integrated into UniProtKB/TrEMBL:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)