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Protein

Glutathione reductase

Gene

GLR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Maintains high levels of reduced glutathione in the cytosol.By similarity

Miscellaneous

The active site is a redox-active disulfide bond.By similarity

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei459Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:GLR1
Ordered Locus Names:YALI0E18029g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679711 – 470Glutathione reductaseAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 49Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6C5H4

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_504088.1

Structurei

3D structure databases

ProteinModelPortaliQ6C5H4
SMRiQ6C5H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000276712
InParanoidiQ6C5H4
KOiK00383
OMAiKCAIIEA
OrthoDBiEOG092C2ILO

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006322 Glutathione_Rdtase_euk/bac
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PANTHERiPTHR42737 PTHR42737, 1 hit
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01421 gluta_reduc_1, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6C5H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIPHYDYL VIGGGSGGVA SARRAASYGA KTLLIEGKAL GGTCVNVGCV
60 70 80 90 100
PKKVMWNASD LAGRIRQAKE YGFPDVDPKY ADNFDWSGFK AKRDAYVKRL
110 120 130 140 150
NGIYERNLQK EGVEYVFGWA TLYKQEGQEF PLVHVKSDDG NTKLYSAKKI
160 170 180 190 200
MIATGGKPRL PDVPGAEYGI DSDGFFALET QPKRVAVVGG GYIGVELAGV
210 220 230 240 250
FHGLNSETTL FCRGQTVLRA FDIMIQDTIT DYYVKEGINV LKGSGVKKIV
260 270 280 290 300
KKDNGELLVT YEQDGAEKDI TLDSLIWTIG REPLKDTLNL GEFGIKTNKR
310 320 330 340 350
GYIEVDEYQR SSVDNIYSLG DVCGKVELTP MAIAAGRKLS NRLFGPTEFK
360 370 380 390 400
NQKQDYTDVP SAVFSHPEVG SIGITEAAAK EQYGEENVKV YTSKFVAMYY
410 420 430 440 450
AMLEEKAPTA YKLVCAGKDE KVVGLHIVGA DSAEILQGFG VAIRMGATKA
460 470
DFDNVVAIHP TSAEELVTMR
Length:470
Mass (Da):51,302
Last modified:August 16, 2004 - v1
Checksum:iB9E4760F181DD143
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382131 Genomic DNA Translation: CAG79681.1
RefSeqiXP_504088.1, XM_504088.1

Genome annotation databases

EnsemblFungiiCAG79681; CAG79681; YALI0_E18029g
GeneIDi2911696
KEGGiyli:YALI0E18029g

Similar proteinsi

Entry informationi

Entry nameiGSHR_YARLI
AccessioniPrimary (citable) accession number: Q6C5H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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