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Q6C5H4 (GSHR_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione reductase

Short name=GR
Short name=GRase
EC=1.8.1.7
Gene names
Name:GLR1
Ordered Locus Names:YALI0E18029g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activity

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond By similarity.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Glutathione reductase
PRO_0000067971

Regions

Nucleotide binding36 – 449FAD By similarity

Sites

Active site4591Proton acceptor By similarity

Amino acid modifications

Disulfide bond44 ↔ 49Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6C5H4 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B9E4760F181DD143

FASTA47051,302
        10         20         30         40         50         60 
MASIPHYDYL VIGGGSGGVA SARRAASYGA KTLLIEGKAL GGTCVNVGCV PKKVMWNASD 

        70         80         90        100        110        120 
LAGRIRQAKE YGFPDVDPKY ADNFDWSGFK AKRDAYVKRL NGIYERNLQK EGVEYVFGWA 

       130        140        150        160        170        180 
TLYKQEGQEF PLVHVKSDDG NTKLYSAKKI MIATGGKPRL PDVPGAEYGI DSDGFFALET 

       190        200        210        220        230        240 
QPKRVAVVGG GYIGVELAGV FHGLNSETTL FCRGQTVLRA FDIMIQDTIT DYYVKEGINV 

       250        260        270        280        290        300 
LKGSGVKKIV KKDNGELLVT YEQDGAEKDI TLDSLIWTIG REPLKDTLNL GEFGIKTNKR 

       310        320        330        340        350        360 
GYIEVDEYQR SSVDNIYSLG DVCGKVELTP MAIAAGRKLS NRLFGPTEFK NQKQDYTDVP 

       370        380        390        400        410        420 
SAVFSHPEVG SIGITEAAAK EQYGEENVKV YTSKFVAMYY AMLEEKAPTA YKLVCAGKDE 

       430        440        450        460        470 
KVVGLHIVGA DSAEILQGFG VAIRMGATKA DFDNVVAIHP TSAEELVTMR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382131 Genomic DNA. Translation: CAG79681.1.
RefSeqXP_504088.1. XM_504088.1.

3D structure databases

ProteinModelPortalQ6C5H4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C5H4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG79681; CAG79681; YALI0_E18029g.
GeneID2911696.
KEGGyli:YALI0E18029g.

Phylogenomic databases

eggNOGCOG1249.
HOGENOMHOG000276712.
KOK00383.
OMAHRQPCKM.
OrthoDBEOG79W9F2.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. SSF55424. 1 hit.
TIGRFAMsTIGR01421. gluta_reduc_1. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSHR_YARLI
AccessionPrimary (citable) accession number: Q6C5H4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families