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Q6C4W6

- PPIB_YARLI

UniProt

Q6C4W6 - PPIB_YARLI

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Protein

Peptidyl-prolyl cis-trans isomerase B

Gene
CPR2, YALI0E23155g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by cyclosporin A (CsA) By similarity.

GO - Molecular functioni

  1. peptide binding Source: UniProtKB-KW
  2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.8)
Short name:
PPIase B
Alternative name(s):
Rotamase B
Gene namesi
Name:CPR2
Ordered Locus Names:YALI0E23155g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome E

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 228204Peptidyl-prolyl cis-trans isomerase BPRO_0000233051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi136 – 1361N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6C4W6.

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6C4W6.

Structurei

3D structure databases

ProteinModelPortaliQ6C4W6.
SMRiQ6C4W6. Positions 29-197.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 192158PPIase cyclophilin-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi225 – 2284Prevents secretion from ER

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065981.
KOiK03768.
OMAiAMARTEE.
OrthoDBiEOG757D7G.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6C4W6-1 [UniParc]FASTAAdd to Basket

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MKLFATIGVL LVALLAFFVQ PAQAEPDAEI THKVYFDIKQ GEESLGKIVM    50
GLYGDVVPKT VENFRALCTG ETGKGYKGSK FHRVIKNFMI QGGDFTRGDG 100
TGGESIYGRK FPDENFQLKH TKPYKLSMAN AGRDTNGSQF FITTVVTSWL 150
DGKHVVFGEV LEGQDIVDAI ENAPTGARSN PKVDITIADA GEIPVEKSET 200
KEAEPAKEDA KEPKEDVKKK GKSDKDEL 228
Length:228
Mass (Da):24,946
Last modified:August 16, 2004 - v1
Checksum:iD89D2EA3BD7BDB6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382131 Genomic DNA. Translation: CAG79895.1.
RefSeqiXP_504296.1. XM_504296.1.

Genome annotation databases

EnsemblFungiiCAG79895; CAG79895; YALI0_E23155g.
GeneIDi2912927.
KEGGiyli:YALI0E23155g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382131 Genomic DNA. Translation: CAG79895.1 .
RefSeqi XP_504296.1. XM_504296.1.

3D structure databases

ProteinModelPortali Q6C4W6.
SMRi Q6C4W6. Positions 29-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C4W6.

Proteomic databases

PRIDEi Q6C4W6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG79895 ; CAG79895 ; YALI0_E23155g .
GeneIDi 2912927.
KEGGi yli:YALI0E23155g.

Phylogenomic databases

eggNOGi COG0652.
HOGENOMi HOG000065981.
KOi K03768.
OMAi AMARTEE.
OrthoDBi EOG757D7G.

Family and domain databases

Gene3Di 2.40.100.10. 1 hit.
InterProi IPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view ]
Pfami PF00160. Pro_isomerase. 1 hit.
[Graphical view ]
PRINTSi PR00153. CSAPPISMRASE.
SUPFAMi SSF50891. SSF50891. 1 hit.
PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPPIB_YARLI
AccessioniPrimary (citable) accession number: Q6C4W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi