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Q6C4W6 (PPIB_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase B

Short name=PPIase B
EC=5.2.1.8
Alternative name(s):
Rotamase B
Gene names
Name:CPR2
Ordered Locus Names:YALI0E23155g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by cyclosporin A (CsA) By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandCyclosporin
   Molecular functionIsomerase
Rotamase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptide binding

Inferred from electronic annotation. Source: UniProtKB-KW

peptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 228204Peptidyl-prolyl cis-trans isomerase B
PRO_0000233051

Regions

Domain35 – 192158PPIase cyclophilin-type
Motif225 – 2284Prevents secretion from ER

Amino acid modifications

Glycosylation1361N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6C4W6 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: D89D2EA3BD7BDB6D

FASTA22824,946
        10         20         30         40         50         60 
MKLFATIGVL LVALLAFFVQ PAQAEPDAEI THKVYFDIKQ GEESLGKIVM GLYGDVVPKT 

        70         80         90        100        110        120 
VENFRALCTG ETGKGYKGSK FHRVIKNFMI QGGDFTRGDG TGGESIYGRK FPDENFQLKH 

       130        140        150        160        170        180 
TKPYKLSMAN AGRDTNGSQF FITTVVTSWL DGKHVVFGEV LEGQDIVDAI ENAPTGARSN 

       190        200        210        220 
PKVDITIADA GEIPVEKSET KEAEPAKEDA KEPKEDVKKK GKSDKDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382131 Genomic DNA. Translation: CAG79895.1.
RefSeqXP_504296.1. XM_504296.1.

3D structure databases

ProteinModelPortalQ6C4W6.
SMRQ6C4W6. Positions 29-197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C4W6.

Proteomic databases

PRIDEQ6C4W6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG79895; CAG79895; YALI0_E23155g.
GeneID2912927.
KEGGyli:YALI0E23155g.

Phylogenomic databases

eggNOGCOG0652.
HOGENOMHOG000065981.
KOK03768.
OMAAMARTEE.
OrthoDBEOG757D7G.

Family and domain databases

Gene3D2.40.100.10. 1 hit.
InterProIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSPR00153. CSAPPISMRASE.
SUPFAMSSF50891. SSF50891. 1 hit.
PROSITEPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPIB_YARLI
AccessionPrimary (citable) accession number: Q6C4W6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families