Reviewed, UniProtKB/Swiss-Prot Q6C423 (JHD1_YARLI)

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1

Gene names

Name:	JHD1
Ordered Locus Names:	YALI0E30393g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.
Catalytic activity	Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2). Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
Cofactor	Binds 1 Fe(2+) ion per subunit By similarity.
Subcellular location	NucleusBy similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain. Contains 1 PHD-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	JmjC domain-containing histone demethylation protein 1		PRO_0000226800
Regions
	Domain	216 – 365	150	JmjC
	Zinc finger	2 – 53	52	PHD-type
Sites
	Metal binding	258	1	Iron; catalytic By similarity
	Metal binding	260	1	Iron; catalytic By similarity
	Metal binding	333	1	Iron; catalytic By similarity
	Binding site	255	1	Substrate By similarity
	Binding site	275	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6C423-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: AF2ACF8B12D39990	FASTA	510	57,824
	10 20 30 40 50 60 MPNRCDFCTS SSTKDKQQWT QCDGCDRWVH DVCVSITDPV SYAKYHCPTC TKTKGPSLYK 70 80 90 100 110 120 RQSKRKKIDI DYAAMHSGNV DMSLRTRHVH SSRFTDVAAS AQNKEPFKRV SGTELTLDWA 130 140 150 160 170 180 QSSDGLNEPV IVPKEYKDTL GMYIPEDLTV RQVAEAVGME SPVEVINVVS QNGSPGWNMG 190 200 210 220 230 240 KWTEYYEDIE GRDTILNVIS LEISASALGK TIVRPTLVRE LDLVDRVWPT NTDAARESKP 250 260 270 280 290 300 RVSLYALMSV EDSFTDFHID FAGSSVFYHV LKGRKSFMFI RPTARNLAAY SQWCLSADQN 310 320 330 340 350 360 VVFLPDVLSP DSDIYTVHLS PGDTMYIPSG WIHAVHSPQD SLVVGGNFIT PLNMKTQIDI 370 380 390 400 410 420 AGIEVRTKVP MKFRYPLFAG VMWYYVLQLL ANPERLNTMS TKERDGLNSV AEYLSGFIKT 430 440 450 460 470 480 MSPTMKDVQY RRFVANFPME IRPFPGKTLL DYCAMLDFYP KGVQETVDID IRKKKGESKE 490 500 510 KHKIESQLPE EKILQGSKLE SKEEVQTENF

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382131 Genomic DNA. Translation: CAG80193.1.
RefSeq	XP_504589.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2912961.
KEGG	yli:YALI0E30393g.
Phylogenomic databases
HOGENOM	Q6C423.
Family and domain databases
InterPro	IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR001965. Znf_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF02373. JmjC. 1 hit. PF00628. PHD. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. PS01359. ZF_PHD_1. False negative. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

JHD1_YARLI

Accession

Primary (citable) accession number: Q6C423

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	August 16, 2004
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)