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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3045-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei398Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:YALI0E30965g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155231 – 524Acetyl-CoA hydrolaseAdd BLAST524

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_504613.1

Structurei

3D structure databases

ProteinModelPortaliQ6C3Z9
SMRiQ6C3Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 283Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172597
InParanoidiQ6C3Z9
KOiK01067
OMAiDEALSWH
OrthoDBiEOG092C1EVJ

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
InterProiView protein in InterPro
IPR026888 AcetylCoA_hyd_C
IPR038460 AcetylCoA_hyd_C_sf
IPR003702 ActCoA_hydro
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF13336 AcetylCoA_hyd_C, 1 hit
PF02550 AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits

Sequencei

Sequence statusi: Complete.

Q6C3Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVLKQRIR YKPYLDKIRT AAQCVDLFGA KPNQYIGWSG FTGVGAPKVV
60 70 80 90 100
PDAVSKHVEE NNLQGHENWR YNLFVGASAG MEIESRWANN NMIARRSPHQ
110 120 130 140 150
VGKPIAAAIN EGRTDFFDKH LSMWAQDLTY GFYTRDKKEN SLDIAVIEAT
160 170 180 190 200
AITEDGHLIP GPAVGASPEI VHMADKIIIE LNTKTPSFEG LHDINMPVLP
210 220 230 240 250
PFRQPYQITD VSQKMGTPYI PLDPSKVVAI VESEFADVVG ANSPADEGSK
260 270 280 290 300
AIAANLIELF QQEVKAGRLP ENLLPLQSGI GNIANAVVEG LADASFKDLN
310 320 330 340 350
VWTEVLQDSF LDFFESGNLN FATATSIRLT EDGFKRFFDN WDEFSKKLLL
360 370 380 390 400
RSQVVSNNPE IIRRLGVIAM NTPVEVDIYA HANSTCVNGS KMLHGLGGSG
410 420 430 440 450
DFLRNAKLSI MHTPSARPSK TDPLGISCIV PFATHIDQTE HDLDIVVTEQ
460 470 480 490 500
GLADLRGLSP KERSREMINK CAHPSYRDQL LAYVEQAEFE CAKSRSLHEP
510 520
HVLKNAFKMH TNLAENGTMR LDKW
Length:524
Mass (Da):58,051
Last modified:August 16, 2004 - v1
Checksum:iEBF47FC1AE51C647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382131 Genomic DNA Translation: CAG80217.1
RefSeqiXP_504613.1, XM_504613.1

Genome annotation databases

EnsemblFungiiCAG80217; CAG80217; YALI0_E30965g
GeneIDi2911920
KEGGiyli:YALI0E30965g

Similar proteinsi

Entry informationi

Entry nameiACH1_YARLI
AccessioniPrimary (citable) accession number: Q6C3Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health