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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 30415-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei398 – 3981Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:YALI0E30965g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Acetyl-CoA hydrolasePRO_0000215523Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6C3Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni279 – 2835Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
InParanoidiQ6C3Z9.
KOiK01067.
OMAiQAGIGNI.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C3Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVLKQRIR YKPYLDKIRT AAQCVDLFGA KPNQYIGWSG FTGVGAPKVV
60 70 80 90 100
PDAVSKHVEE NNLQGHENWR YNLFVGASAG MEIESRWANN NMIARRSPHQ
110 120 130 140 150
VGKPIAAAIN EGRTDFFDKH LSMWAQDLTY GFYTRDKKEN SLDIAVIEAT
160 170 180 190 200
AITEDGHLIP GPAVGASPEI VHMADKIIIE LNTKTPSFEG LHDINMPVLP
210 220 230 240 250
PFRQPYQITD VSQKMGTPYI PLDPSKVVAI VESEFADVVG ANSPADEGSK
260 270 280 290 300
AIAANLIELF QQEVKAGRLP ENLLPLQSGI GNIANAVVEG LADASFKDLN
310 320 330 340 350
VWTEVLQDSF LDFFESGNLN FATATSIRLT EDGFKRFFDN WDEFSKKLLL
360 370 380 390 400
RSQVVSNNPE IIRRLGVIAM NTPVEVDIYA HANSTCVNGS KMLHGLGGSG
410 420 430 440 450
DFLRNAKLSI MHTPSARPSK TDPLGISCIV PFATHIDQTE HDLDIVVTEQ
460 470 480 490 500
GLADLRGLSP KERSREMINK CAHPSYRDQL LAYVEQAEFE CAKSRSLHEP
510 520
HVLKNAFKMH TNLAENGTMR LDKW
Length:524
Mass (Da):58,051
Last modified:August 16, 2004 - v1
Checksum:iEBF47FC1AE51C647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382131 Genomic DNA. Translation: CAG80217.1.
RefSeqiXP_504613.1. XM_504613.1.

Genome annotation databases

EnsemblFungiiCAG80217; CAG80217; YALI0_E30965g.
GeneIDi2911920.
KEGGiyli:YALI0E30965g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382131 Genomic DNA. Translation: CAG80217.1.
RefSeqiXP_504613.1. XM_504613.1.

3D structure databases

ProteinModelPortaliQ6C3Z9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG80217; CAG80217; YALI0_E30965g.
GeneIDi2911920.
KEGGiyli:YALI0E30965g.

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
InParanoidiQ6C3Z9.
KOiK01067.
OMAiQAGIGNI.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACH1_YARLI
AccessioniPrimary (citable) accession number: Q6C3Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: August 16, 2004
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.