Reviewed, UniProtKB/Swiss-Prot Q6C3Z9 (ACH1_YARLI)

Names and origin

Protein names

Recommended name:
    Acetyl-CoA hydrolase
    EC=3.1.2.1
Alternative name(s):
    Acetyl-CoA deacylase
      Short name=Acetyl-CoA acylase

Gene names

Name:	ACH1
Ordered Locus Names:	YALI0E30965g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Acetyl-CoA hydrolase		PRO_0000215523

Sequences

	Sequence		Length	Mass (Da)
	Q6C3Z9-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: EBF47FC1AE51C647	FASTA	524	58,051
	10 20 30 40 50 60 MSAVLKQRIR YKPYLDKIRT AAQCVDLFGA KPNQYIGWSG FTGVGAPKVV PDAVSKHVEE 70 80 90 100 110 120 NNLQGHENWR YNLFVGASAG MEIESRWANN NMIARRSPHQ VGKPIAAAIN EGRTDFFDKH 130 140 150 160 170 180 LSMWAQDLTY GFYTRDKKEN SLDIAVIEAT AITEDGHLIP GPAVGASPEI VHMADKIIIE 190 200 210 220 230 240 LNTKTPSFEG LHDINMPVLP PFRQPYQITD VSQKMGTPYI PLDPSKVVAI VESEFADVVG 250 260 270 280 290 300 ANSPADEGSK AIAANLIELF QQEVKAGRLP ENLLPLQSGI GNIANAVVEG LADASFKDLN 310 320 330 340 350 360 VWTEVLQDSF LDFFESGNLN FATATSIRLT EDGFKRFFDN WDEFSKKLLL RSQVVSNNPE 370 380 390 400 410 420 IIRRLGVIAM NTPVEVDIYA HANSTCVNGS KMLHGLGGSG DFLRNAKLSI MHTPSARPSK 430 440 450 460 470 480 TDPLGISCIV PFATHIDQTE HDLDIVVTEQ GLADLRGLSP KERSREMINK CAHPSYRDQL 490 500 510 520 LAYVEQAEFE CAKSRSLHEP HVLKNAFKMH TNLAENGTMR LDKW

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382131 Genomic DNA. Translation: CAG80217.1.
RefSeq	XP_504613.1.
3D structure databases
SMR	Q6C3Z9. Positions 6-521.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6C3Z9.
Genome annotation databases
GeneID	2911920.
GenomeReviews	Gene locus YALI0E30965g in contig CR382131_GR.
KEGG	yli:YALI0E30965g.
Phylogenomic databases
eggNOG	fuNOG04759.
HOGENOM	HBG289696.
OMA	DEALSWH.
OrthoDB	EOG951G6X.
PhylomeDB	Q6C3Z9.
Enzyme and pathway databases
BRENDA	3.1.2.1. 3602.
Family and domain databases
InterPro	IPR003702. ActCoA_hydro. [Graphical view]
PANTHER	PTHR21432. ActCoA_hydro. 1 hit.
Pfam	PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_YARLI

Accession

Primary (citable) accession number: Q6C3Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	August 16, 2004
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)