SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6C2U0

- HIS4_YARLI

UniProt

Q6C2U0 - HIS4_YARLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Gene
HIS6, YALI0F05192g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:HIS6
Ordered Locus Names:YALI0F05192g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome F

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2642641-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
PRO_0000141962Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6C2U0.

Structurei

3D structure databases

ProteinModelPortaliQ6C2U0.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000172261.
KOiK01814.
OMAiFVAMNKW.
OrthoDBiEOG7ZWDC9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR21169. PTHR21169. 1 hit.
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6C2U0-1 [UniParc]FASTAAdd to Basket

« Hide

MTKFRGCIDI HSGQVKQIVG GTLTDSDADL KTNFVATQPP GYFAQLYKDN    50
NVVGTHVIKL GPGCDEAAEE ALAGWPDHLQ IGGGINHDNA EKWIKLGASH 100
VIVTSFLFPD AKLDMKRLTD LEAILEPYGG KKRIVVDLSC RRKDGKWVVA 150
MNRWQTLTDT EVNKETLEQL AKHCDEFLIH AADVEGLCNG IDEELVTKLG 200
EWLEEGHLPP VTYAGGAKNI DDLALVQKLS HGKVDLTYGS ALDVFGGDKV 250
KFSDCVEWNE KMHK 264
Length:264
Mass (Da):29,098
Last modified:August 16, 2004 - v1
Checksum:i1FAA1398C238C79A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG77829.1.
RefSeqiXP_505022.1. XM_505022.1.

Genome annotation databases

EnsemblFungiiCAG77829; CAG77829; YALI0_F05192g.
GeneIDi2908162.
KEGGiyli:YALI0F05192g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG77829.1 .
RefSeqi XP_505022.1. XM_505022.1.

3D structure databases

ProteinModelPortali Q6C2U0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 4952.Q6C2U0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG77829 ; CAG77829 ; YALI0_F05192g .
GeneIDi 2908162.
KEGGi yli:YALI0F05192g.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000172261.
KOi K01814.
OMAi FVAMNKW.
OrthoDBi EOG7ZWDC9.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
PANTHERi PTHR21169. PTHR21169. 1 hit.
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02129. hisA_euk. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiHIS4_YARLI
AccessioniPrimary (citable) accession number: Q6C2U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi