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Q6C2D9

- ERG6_YARLI

UniProt

Q6C2D9 - ERG6_YARLI

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Protein

Sterol 24-C-methyltransferase

Gene
ERG6, YALI0F08701g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
Ordered Locus Names:YALI0F08701g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome F

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Sterol 24-C-methyltransferasePRO_0000124798Add
BLAST

Proteomic databases

PRIDEiQ6C2D9.

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6C2D9.

Structurei

3D structure databases

ProteinModelPortaliQ6C2D9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0500.
HOGENOMiHOG000171097.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C2D9-1 [UniParc]FASTAAdd to Basket

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MSSNIKLAQK DYKGDKEFAA ALHGKEGHKK HGLGAVMSKN KDAQAAAVEG    50
FFRNWGDKDR SKIEDADEQG RIEDYAGLTK HYYNLVTDFY EYGWGSSFHF 100
SRYYKGEAFR QATARHEHYL AYKMGIQPGM KVLDVGCGVG GPAREIARFT 150
GANIVGLNNN DYQVERGTHY SEVQGFGDQV TYVKGDFMQM DFPDNSFDAV 200
YAIEATVHAP VLEGVYSEIF RVLKPGGVFG VYEWVMTDEY DESNPEHRDI 250
CYGIEKGDGI PKMYKREVAV KALENVGFDI EYQEDLAADD AEVPWYYPLA 300
GEWKYVQSLN DIVTIGRTSR LGRMVTMNVI GALEKIGLAP QGSRQVTEAL 350
EDAAVNLVAG GKKKLFTPMM LFVSRKPEDK N 381
Length:381
Mass (Da):42,703
Last modified:August 16, 2004 - v1
Checksum:i0EE23241B436B147
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG77980.1.
RefSeqiXP_505173.1. XM_505173.1.

Genome annotation databases

EnsemblFungiiCAG77980; CAG77980; YALI0_F08701g.
GeneIDi2908368.
KEGGiyli:YALI0F08701g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG77980.1 .
RefSeqi XP_505173.1. XM_505173.1.

3D structure databases

ProteinModelPortali Q6C2D9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C2D9.

Proteomic databases

PRIDEi Q6C2D9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG77980 ; CAG77980 ; YALI0_F08701g .
GeneIDi 2908368.
KEGGi yli:YALI0F08701g.

Phylogenomic databases

eggNOGi COG0500.
HOGENOMi HOG000171097.
KOi K00559.
OMAi FHFCRFS.
OrthoDBi EOG7DVDMW.

Enzyme and pathway databases

UniPathwayi UPA00768 ; UER00760 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiERG6_YARLI
AccessioniPrimary (citable) accession number: Q6C2D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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