Q6C2D9 (ERG6_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sterol 24-C-methyltransferase
EC=2.1.1.41

Alternative name(s):
Delta(24)-sterol C-methyltransferase

Gene names

Name:	ERG6
Ordered Locus Names:	YALI0F08701g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Sterol 24-C-methyltransferase		PRO_0000124798

Sequences

	Sequence		Length	Mass (Da)
	Q6C2D9 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 0EE23241B436B147	FASTA	381	42,703
	10 20 30 40 50 60 MSSNIKLAQK DYKGDKEFAA ALHGKEGHKK HGLGAVMSKN KDAQAAAVEG FFRNWGDKDR 70 80 90 100 110 120 SKIEDADEQG RIEDYAGLTK HYYNLVTDFY EYGWGSSFHF SRYYKGEAFR QATARHEHYL 130 140 150 160 170 180 AYKMGIQPGM KVLDVGCGVG GPAREIARFT GANIVGLNNN DYQVERGTHY SEVQGFGDQV 190 200 210 220 230 240 TYVKGDFMQM DFPDNSFDAV YAIEATVHAP VLEGVYSEIF RVLKPGGVFG VYEWVMTDEY 250 260 270 280 290 300 DESNPEHRDI CYGIEKGDGI PKMYKREVAV KALENVGFDI EYQEDLAADD AEVPWYYPLA 310 320 330 340 350 360 GEWKYVQSLN DIVTIGRTSR LGRMVTMNVI GALEKIGLAP QGSRQVTEAL EDAAVNLVAG 370 380 GKKKLFTPMM LFVSRKPEDK N

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382132 Genomic DNA. Translation: CAG77980.1.
RefSeq	XP_505173.1. XM_505173.1.
3D structure databases
ProteinModelPortal	Q6C2D9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6C2D9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2908368.
GenomeReviews	Gene locus YALI0F08701g in contig CR382132_GR.
KEGG	yli:YALI0F08701g.
Phylogenomic databases
eggNOG	fuNOG04306.
HOGENOM	HBG316404.
OMA	KLFTPMM.
OrthoDB	EOG4HHSB5.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
KO	K00559.
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_YARLI

Accession

Primary (citable) accession number: Q6C2D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program