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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi: ergosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes ergosterol from zymosterol.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Sterol 24-C-methyltransferase (ERG6)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway ergosterol biosynthesis, which is itself part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ergosterol from zymosterol, the pathway ergosterol biosynthesis and in Steroid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
Ordered Locus Names:YALI0F08701g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001247981 – 381Sterol 24-C-methyltransferaseAdd BLAST381

Proteomic databases

PRIDEiQ6C2D9

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_505173.1

Structurei

3D structure databases

ProteinModelPortaliQ6C2D9
SMRiQ6C2D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000171097
InParanoidiQ6C2D9
KOiK00559
OMAiGIPKMYK
OrthoDBiEOG092C2LI4

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR030384 MeTrfase_SMT
IPR029063 SAM-dependent_MTases
IPR013705 Sterol_MeTrfase_C
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
PF08498 Sterol_MT_C, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
PROSITEiView protein in PROSITE
PS51685 SAM_MT_ERG6_SMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6C2D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNIKLAQK DYKGDKEFAA ALHGKEGHKK HGLGAVMSKN KDAQAAAVEG
60 70 80 90 100
FFRNWGDKDR SKIEDADEQG RIEDYAGLTK HYYNLVTDFY EYGWGSSFHF
110 120 130 140 150
SRYYKGEAFR QATARHEHYL AYKMGIQPGM KVLDVGCGVG GPAREIARFT
160 170 180 190 200
GANIVGLNNN DYQVERGTHY SEVQGFGDQV TYVKGDFMQM DFPDNSFDAV
210 220 230 240 250
YAIEATVHAP VLEGVYSEIF RVLKPGGVFG VYEWVMTDEY DESNPEHRDI
260 270 280 290 300
CYGIEKGDGI PKMYKREVAV KALENVGFDI EYQEDLAADD AEVPWYYPLA
310 320 330 340 350
GEWKYVQSLN DIVTIGRTSR LGRMVTMNVI GALEKIGLAP QGSRQVTEAL
360 370 380
EDAAVNLVAG GKKKLFTPMM LFVSRKPEDK N
Length:381
Mass (Da):42,703
Last modified:August 16, 2004 - v1
Checksum:i0EE23241B436B147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382132 Genomic DNA Translation: CAG77980.1
RefSeqiXP_505173.1, XM_505173.1

Genome annotation databases

EnsemblFungiiCAG77980; CAG77980; YALI0_F08701g
GeneIDi2908368
KEGGiyli:YALI0F08701g

Similar proteinsi

Entry informationi

Entry nameiERG6_YARLI
AccessioniPrimary (citable) accession number: Q6C2D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health