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Q6C2D9 (ERG6_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sterol 24-C-methyltransferase

EC=2.1.1.41
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene names
Name:ERG6
Ordered Locus Names:YALI0F08701g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Sterol 24-C-methyltransferase
PRO_0000124798

Sequences

Sequence LengthMass (Da)Tools
Q6C2D9 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 0EE23241B436B147

FASTA38142,703
        10         20         30         40         50         60 
MSSNIKLAQK DYKGDKEFAA ALHGKEGHKK HGLGAVMSKN KDAQAAAVEG FFRNWGDKDR 

        70         80         90        100        110        120 
SKIEDADEQG RIEDYAGLTK HYYNLVTDFY EYGWGSSFHF SRYYKGEAFR QATARHEHYL 

       130        140        150        160        170        180 
AYKMGIQPGM KVLDVGCGVG GPAREIARFT GANIVGLNNN DYQVERGTHY SEVQGFGDQV 

       190        200        210        220        230        240 
TYVKGDFMQM DFPDNSFDAV YAIEATVHAP VLEGVYSEIF RVLKPGGVFG VYEWVMTDEY 

       250        260        270        280        290        300 
DESNPEHRDI CYGIEKGDGI PKMYKREVAV KALENVGFDI EYQEDLAADD AEVPWYYPLA 

       310        320        330        340        350        360 
GEWKYVQSLN DIVTIGRTSR LGRMVTMNVI GALEKIGLAP QGSRQVTEAL EDAAVNLVAG 

       370        380 
GKKKLFTPMM LFVSRKPEDK N 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382132 Genomic DNA. Translation: CAG77980.1.
RefSeqXP_505173.1. XM_505173.1.

3D structure databases

ProteinModelPortalQ6C2D9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C2D9.

Proteomic databases

PRIDEQ6C2D9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG77980; CAG77980; YALI0_F08701g.
GeneID2908368.
KEGGyli:YALI0F08701g.

Phylogenomic databases

eggNOGCOG0500.
HOGENOMHOG000171097.
KOK00559.
OMAFHFCRFS.
OrthoDBEOG7DVDMW.

Enzyme and pathway databases

UniPathwayUPA00768; UER00760.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 2 hits.
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG6_YARLI
AccessionPrimary (citable) accession number: Q6C2D9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways