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Q6C2D9

- ERG6_YARLI

UniProt

Q6C2D9 - ERG6_YARLI

Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:ERG6
    Ordered Locus Names:YALI0F08701g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome F

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Sterol 24-C-methyltransferasePRO_0000124798Add
    BLAST

    Proteomic databases

    PRIDEiQ6C2D9.

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6C2D9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6C2D9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0500.
    HOGENOMiHOG000171097.
    KOiK00559.
    OMAiFHFCRFS.
    OrthoDBiEOG7DVDMW.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6C2D9-1 [UniParc]FASTAAdd to Basket

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    MSSNIKLAQK DYKGDKEFAA ALHGKEGHKK HGLGAVMSKN KDAQAAAVEG    50
    FFRNWGDKDR SKIEDADEQG RIEDYAGLTK HYYNLVTDFY EYGWGSSFHF 100
    SRYYKGEAFR QATARHEHYL AYKMGIQPGM KVLDVGCGVG GPAREIARFT 150
    GANIVGLNNN DYQVERGTHY SEVQGFGDQV TYVKGDFMQM DFPDNSFDAV 200
    YAIEATVHAP VLEGVYSEIF RVLKPGGVFG VYEWVMTDEY DESNPEHRDI 250
    CYGIEKGDGI PKMYKREVAV KALENVGFDI EYQEDLAADD AEVPWYYPLA 300
    GEWKYVQSLN DIVTIGRTSR LGRMVTMNVI GALEKIGLAP QGSRQVTEAL 350
    EDAAVNLVAG GKKKLFTPMM LFVSRKPEDK N 381
    Length:381
    Mass (Da):42,703
    Last modified:August 16, 2004 - v1
    Checksum:i0EE23241B436B147
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382132 Genomic DNA. Translation: CAG77980.1.
    RefSeqiXP_505173.1. XM_505173.1.

    Genome annotation databases

    EnsemblFungiiCAG77980; CAG77980; YALI0_F08701g.
    GeneIDi2908368.
    KEGGiyli:YALI0F08701g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382132 Genomic DNA. Translation: CAG77980.1 .
    RefSeqi XP_505173.1. XM_505173.1.

    3D structure databases

    ProteinModelPortali Q6C2D9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6C2D9.

    Proteomic databases

    PRIDEi Q6C2D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG77980 ; CAG77980 ; YALI0_F08701g .
    GeneIDi 2908368.
    KEGGi yli:YALI0F08701g.

    Phylogenomic databases

    eggNOGi COG0500.
    HOGENOMi HOG000171097.
    KOi K00559.
    OMAi FHFCRFS.
    OrthoDBi EOG7DVDMW.

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiERG6_YARLI
    AccessioniPrimary (citable) accession number: Q6C2D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3