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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway: ergosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes ergosterol from zymosterol.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Sterol 24-C-methyltransferase (ERG6)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway ergosterol biosynthesis, which is itself part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ergosterol from zymosterol, the pathway ergosterol biosynthesis and in Steroid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
Ordered Locus Names:YALI0F08701g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Sterol 24-C-methyltransferasePRO_0000124798Add
BLAST

Proteomic databases

PRIDEiQ6C2D9.

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_505173.1.

Structurei

3D structure databases

ProteinModelPortaliQ6C2D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0500.
HOGENOMiHOG000171097.
InParanoidiQ6C2D9.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR030384. MeTrfase_SMT.
IPR029063. SAM-dependent_MTases.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6C2D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNIKLAQK DYKGDKEFAA ALHGKEGHKK HGLGAVMSKN KDAQAAAVEG
60 70 80 90 100
FFRNWGDKDR SKIEDADEQG RIEDYAGLTK HYYNLVTDFY EYGWGSSFHF
110 120 130 140 150
SRYYKGEAFR QATARHEHYL AYKMGIQPGM KVLDVGCGVG GPAREIARFT
160 170 180 190 200
GANIVGLNNN DYQVERGTHY SEVQGFGDQV TYVKGDFMQM DFPDNSFDAV
210 220 230 240 250
YAIEATVHAP VLEGVYSEIF RVLKPGGVFG VYEWVMTDEY DESNPEHRDI
260 270 280 290 300
CYGIEKGDGI PKMYKREVAV KALENVGFDI EYQEDLAADD AEVPWYYPLA
310 320 330 340 350
GEWKYVQSLN DIVTIGRTSR LGRMVTMNVI GALEKIGLAP QGSRQVTEAL
360 370 380
EDAAVNLVAG GKKKLFTPMM LFVSRKPEDK N
Length:381
Mass (Da):42,703
Last modified:August 16, 2004 - v1
Checksum:i0EE23241B436B147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382132 Genomic DNA. Translation: CAG77980.1.
RefSeqiXP_505173.1. XM_505173.1.

Genome annotation databases

EnsemblFungiiCAG77980; CAG77980; YALI0_F08701g.
GeneIDi2908368.
KEGGiyli:YALI0F08701g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382132 Genomic DNA. Translation: CAG77980.1.
RefSeqiXP_505173.1. XM_505173.1.

3D structure databases

ProteinModelPortaliQ6C2D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.XP_505173.1.

Proteomic databases

PRIDEiQ6C2D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG77980; CAG77980; YALI0_F08701g.
GeneIDi2908368.
KEGGiyli:YALI0F08701g.

Phylogenomic databases

eggNOGiCOG0500.
HOGENOMiHOG000171097.
InParanoidiQ6C2D9.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR030384. MeTrfase_SMT.
IPR029063. SAM-dependent_MTases.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERG6_YARLI
AccessioniPrimary (citable) accession number: Q6C2D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: June 24, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.