Q6C2D9 (ERG6_YARLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 48.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Sterol 24-C-methyltransferase EC=2.1.1.41 Alternative name(s): Delta(24)-sterol C-methyltransferase | ||||
| Gene names |
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| Organism | Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) | ||||
| Taxonomic identifier | 284591 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia |
Protein attributes
| Sequence length | 381 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. |
| Pathway | Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5. |
| Sequence similarities | Belongs to the methyltransferase superfamily. ERG6 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 381 | 381 | Sterol 24-C-methyltransferase | PRO_0000124798 | |||
Sequences
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References
| [1] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR382132 Genomic DNA. Translation: CAG77980.1. |
| RefSeq | XP_505173.1. XM_505173.1. |
3D structure databases | |
| ProteinModelPortal | Q6C2D9. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6C2D9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2908368. |
| GenomeReviews | Gene locus YALI0F08701g in contig CR382132_GR. |
| KEGG | yli:YALI0F08701g. |
Phylogenomic databases | |
| eggNOG | fuNOG04306. |
| HOGENOM | HBG316404. |
| OMA | KLFTPMM. |
| OrthoDB | EOG4HHSB5. |
Family and domain databases | |
| InterPro | IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view] |
| KO | K00559. |
| Pfam | PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ERG6_YARLI | ||||||||
| Accession | Primary (citable) accession number: Q6C2D9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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