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Q6C195

- SSU72_YARLI

UniProt

Q6C195 - SSU72_YARLI

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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:YALI0F18194g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome F

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255613Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Protein-protein interaction databases

STRINGi4952.Q6C195.

Structurei

3D structure databases

ProteinModelPortaliQ6C195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ6C195.
KOiK15544.
OMAiNRPFLHT.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6C195-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELKMCTVC ASNQNRSMEA HKVLKEAGFD VESYGTGSAV RLPGPAYDKP
60 70 80 90 100
NIYAFGTPYD DIYNELSAQD ERLYTANGLL TMLDRNRKIK TAPERWVEHK
110 120 130 140 150
NVFDVVFTCE ERCFEAVCDD LMDRGEKLQR PVHVINVDIR DNHEDSVIGA
160 170 180 190
QGILKLARSL ADSKDLDAQI MGIMDSWQEQ HPKLPLMHAV GYF
Length:193
Mass (Da):21,900
Last modified:August 16, 2004 - v1
Checksum:iB670E9811714D5B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG78376.1.
RefSeqiXP_505567.1. XM_505567.1.

Genome annotation databases

EnsemblFungiiCAG78376; CAG78376; YALI0_F18194g.
GeneIDi2908669.
KEGGiyli:YALI0F18194g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG78376.1 .
RefSeqi XP_505567.1. XM_505567.1.

3D structure databases

ProteinModelPortali Q6C195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG78376 ; CAG78376 ; YALI0_F18194g .
GeneIDi 2908669.
KEGGi yli:YALI0F18194g.

Phylogenomic databases

eggNOGi COG5211.
HOGENOMi HOG000183445.
InParanoidi Q6C195.
KOi K15544.
OMAi NRPFLHT.
OrthoDBi EOG7GTTG0.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR006811. RNA_pol_II_suA.
[Graphical view ]
PANTHERi PTHR20383. PTHR20383. 1 hit.
Pfami PF04722. Ssu72. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiSSU72_YARLI
AccessioniPrimary (citable) accession number: Q6C195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3