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Q6C195 (SSU72_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Short name=CTD phosphatase SSU72
EC=3.1.3.16
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene names
Name:SSU72
Ordered Locus Names:YALI0F18194g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1) By similarity.

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193RNA polymerase II subunit A C-terminal domain phosphatase SSU72
PRO_0000255613

Sequences

Sequence LengthMass (Da)Tools
Q6C195 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B670E9811714D5B0

FASTA19321,900
        10         20         30         40         50         60 
MTELKMCTVC ASNQNRSMEA HKVLKEAGFD VESYGTGSAV RLPGPAYDKP NIYAFGTPYD 

        70         80         90        100        110        120 
DIYNELSAQD ERLYTANGLL TMLDRNRKIK TAPERWVEHK NVFDVVFTCE ERCFEAVCDD 

       130        140        150        160        170        180 
LMDRGEKLQR PVHVINVDIR DNHEDSVIGA QGILKLARSL ADSKDLDAQI MGIMDSWQEQ 

       190 
HPKLPLMHAV GYF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382132 Genomic DNA. Translation: CAG78376.1.
RefSeqXP_505567.1. XM_505567.1.

3D structure databases

ProteinModelPortalQ6C195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG78376; CAG78376; YALI0_F18194g.
GeneID2908669.
KEGGyli:YALI0F18194g.

Phylogenomic databases

eggNOGCOG5211.
HOGENOMHOG000183445.
KOK15544.
OMANRPFLHT.
OrthoDBEOG7GTTG0.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSSU72_YARLI
AccessionPrimary (citable) accession number: Q6C195
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families