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Q6C195

- SSU72_YARLI

UniProt

Q6C195 - SSU72_YARLI

Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
    Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
    Short name:
    CTD phosphatase SSU72
    Alternative name(s):
    Suppressor of SUA7 protein 2 homolog
    Gene namesi
    Name:SSU72
    Ordered Locus Names:YALI0F18194g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome F

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255613Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

    Protein-protein interaction databases

    STRINGi4952.Q6C195.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6C195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SSU72 phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG5211.
    HOGENOMiHOG000183445.
    KOiK15544.
    OMAiNRPFLHT.
    OrthoDBiEOG7GTTG0.

    Family and domain databases

    InterProiIPR023485. Ptyr_pPase_SF.
    IPR006811. RNA_pol_II_suA.
    [Graphical view]
    PANTHERiPTHR20383. PTHR20383. 1 hit.
    PfamiPF04722. Ssu72. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6C195-1 [UniParc]FASTAAdd to Basket

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    MTELKMCTVC ASNQNRSMEA HKVLKEAGFD VESYGTGSAV RLPGPAYDKP    50
    NIYAFGTPYD DIYNELSAQD ERLYTANGLL TMLDRNRKIK TAPERWVEHK 100
    NVFDVVFTCE ERCFEAVCDD LMDRGEKLQR PVHVINVDIR DNHEDSVIGA 150
    QGILKLARSL ADSKDLDAQI MGIMDSWQEQ HPKLPLMHAV GYF 193
    Length:193
    Mass (Da):21,900
    Last modified:August 16, 2004 - v1
    Checksum:iB670E9811714D5B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382132 Genomic DNA. Translation: CAG78376.1.
    RefSeqiXP_505567.1. XM_505567.1.

    Genome annotation databases

    EnsemblFungiiCAG78376; CAG78376; YALI0_F18194g.
    GeneIDi2908669.
    KEGGiyli:YALI0F18194g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382132 Genomic DNA. Translation: CAG78376.1 .
    RefSeqi XP_505567.1. XM_505567.1.

    3D structure databases

    ProteinModelPortali Q6C195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6C195.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG78376 ; CAG78376 ; YALI0_F18194g .
    GeneIDi 2908669.
    KEGGi yli:YALI0F18194g.

    Phylogenomic databases

    eggNOGi COG5211.
    HOGENOMi HOG000183445.
    KOi K15544.
    OMAi NRPFLHT.
    OrthoDBi EOG7GTTG0.

    Family and domain databases

    InterProi IPR023485. Ptyr_pPase_SF.
    IPR006811. RNA_pol_II_suA.
    [Graphical view ]
    PANTHERi PTHR20383. PTHR20383. 1 hit.
    Pfami PF04722. Ssu72. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiSSU72_YARLI
    AccessioniPrimary (citable) accession number: Q6C195
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3