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Q6C141 (DUT_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT1
Ordered Locus Names:YALI0F19448g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182936

Regions

Region62 – 643Substrate binding By similarity
Region76 – 794Substrate binding By similarity
Region137 – 1382Substrate binding By similarity

Sites

Binding site871Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6C141 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 1BB1C6A534555AEF

FASTA15716,857
        10         20         30         40         50         60 
MSLKVAFLNE NARAPTRGSV HAAGYDLYAA EEKTIPANGR GLVDLGLSMS IPEGTYARIA 

        70         80         90        100        110        120 
PRSGLAVKNG LSTGAGVIDY DYRGPVKVML FNHSTEDFNV TIGDRVAQMI LERIVTPEVQ 

       130        140        150 
VVQTNDLEST ERGAGGFGST GINDEKKRKL DEAEAKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382132 Genomic DNA. Translation: CAG78430.1.
RefSeqXP_505621.1. XM_505621.1.

3D structure databases

ProteinModelPortalQ6C141.
SMRQ6C141. Positions 3-119.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C141.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG78430; CAG78430; YALI0_F19448g.
GeneID2908309.
KEGGyli:YALI0F19448g.

Phylogenomic databases

eggNOGCOG0756.
HOGENOMHOG000028966.
KOK01520.
OMAENCAHEV.
OrthoDBEOG7T7H6C.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

Gene3D2.70.40.10. 1 hit.
InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 1 hit.
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_YARLI
AccessionPrimary (citable) accession number: Q6C141
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways