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Q6C093 (UBC2_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 2

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein UBC2
Ubiquitin-protein ligase UBC2
Gene names
Name:UBC2
Ordered Locus Names:YALI0F26697g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 151151Ubiquitin-conjugating enzyme E2 2
PRO_0000082539

Sites

Active site881Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6C093 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: C31B848BA8AC0BE1

FASTA15117,198
        10         20         30         40         50         60 
MSTTARRRLM RDFKRMQQDP PQGVSASPVA DNVLTWNAVI IGPAETPFED GTFRMVLQFD 

        70         80         90        100        110        120 
EQYPNKPPAV KFVSQMFHPN VYSSGELCLD ILQNRWSPTY DVAAILTSVQ SLLNDPNTSS 

       130        140        150 
PANVEASMLY KDHRQQYEKR VRDTVEASWT D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382132 Genomic DNA. Translation: CAG78731.1.
RefSeqXP_505919.1. XM_505919.1.

3D structure databases

ProteinModelPortalQ6C093.
SMRQ6C093. Positions 2-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6C093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG78731; CAG78731; YALI0_F26697g.
GeneID2908858.
KEGGyli:YALI0F26697g.

Phylogenomic databases

eggNOGCOG5078.
HOGENOMHOG000233454.
KOK10573.
OMAPVPDNVM.
OrthoDBEOG7SBP18.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBC2_YARLI
AccessionPrimary (citable) accession number: Q6C093
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways