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Q6C044

- ATG18_YARLI

UniProt

Q6C044 - ATG18_YARLI

Protein

Autophagy-related protein 18

Gene

ATG18

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication By similarity.By similarity

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 18
    Gene namesi
    Name:ATG18
    Ordered Locus Names:YALI0F27907g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome F

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
    3. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Autophagy-related protein 18PRO_0000050873Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PI(3,5)P2 regulatory complex.By similarity

    Protein-protein interaction databases

    STRINGi4952.Q6C044.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6C044.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati193 – 23341WD 1Add
    BLAST
    Repeati238 – 27740WD 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi234 – 2385FRRGT-motifBy similarity

    Domaini

    The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
    The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

    Sequence similaritiesi

    Belongs to the WD repeat SVP1 family.Curated
    Contains 2 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG317564.
    HOGENOMiHOG000217543.
    KOiK17908.
    OMAiVVHTIRD.
    OrthoDBiEOG7BW0V3.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6C044-1 [UniParc]FASTAAdd to Basket

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    MSDSINFVSF NQDYSCVSVG TPQGYKIYNC DPFGKCFSKA DGGMGIVEML    50
    FCTSLIAVVG MGDQPQNSPR RLKIVNTKRQ STICELTFPT AVLGVRLNRQ 100
    RLVVLLQDQI YIYDISNMKL VHTIETSPNP GAVCALSASS SDNNNYLVYP 150
    FPAPSSTAFN PGENNINDSS PNRKGDVTIF DCNSLQPVNV VEAHKTPLAC 200
    LSLNSDGTLL ATASDKGTII RVFSVPKAQK LYEFRRGTYP AQIFSINFNL 250
    ASNLMAVSSA TETVHIFQLE AGVSSTPEVP QDTELAIPTR TPQQKGMASV 300
    FRKSSRSLGK GLAGAVGSYL PQTFTGMWEP LRDFAFIKQT SLPGTRSVVS 350
    VTSTNPPQVL VVTLEGYFYQ YTLDLEKGGE CDLIRQYSLL DNVEGSLYGP 400
    Length:400
    Mass (Da):43,565
    Last modified:August 16, 2004 - v1
    Checksum:i1C14722C0F67BBC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382132 Genomic DNA. Translation: CAG78780.1.
    RefSeqiXP_505968.1. XM_505968.1.

    Genome annotation databases

    EnsemblFungiiCAG78780; CAG78780; YALI0_F27907g.
    GeneIDi2908106.
    KEGGiyli:YALI0F27907g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382132 Genomic DNA. Translation: CAG78780.1 .
    RefSeqi XP_505968.1. XM_505968.1.

    3D structure databases

    ProteinModelPortali Q6C044.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6C044.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG78780 ; CAG78780 ; YALI0_F27907g .
    GeneIDi 2908106.
    KEGGi yli:YALI0F27907g.

    Phylogenomic databases

    eggNOGi NOG317564.
    HOGENOMi HOG000217543.
    KOi K17908.
    OMAi VVHTIRD.
    OrthoDBi EOG7BW0V3.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiATG18_YARLI
    AccessioniPrimary (citable) accession number: Q6C044
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3