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Q6C044

- ATG18_YARLI

UniProt

Q6C044 - ATG18_YARLI

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Protein

Autophagy-related protein 18

Gene

ATG18

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).By similarity

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 18
Gene namesi
Name:ATG18
Ordered Locus Names:YALI0F27907g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome F

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
  3. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Autophagy-related protein 18PRO_0000050873Add
BLAST

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex.By similarity

Protein-protein interaction databases

STRINGi4952.Q6C044.

Structurei

3D structure databases

ProteinModelPortaliQ6C044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati193 – 23341WD 1Add
BLAST
Repeati238 – 27740WD 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi234 – 2385FRRGT-motifBy similarity

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 2 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317564.
HOGENOMiHOG000217543.
InParanoidiQ6C044.
KOiK17908.
OMAiVVHTIRD.
OrthoDBiEOG7BW0V3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6C044-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSINFVSF NQDYSCVSVG TPQGYKIYNC DPFGKCFSKA DGGMGIVEML
60 70 80 90 100
FCTSLIAVVG MGDQPQNSPR RLKIVNTKRQ STICELTFPT AVLGVRLNRQ
110 120 130 140 150
RLVVLLQDQI YIYDISNMKL VHTIETSPNP GAVCALSASS SDNNNYLVYP
160 170 180 190 200
FPAPSSTAFN PGENNINDSS PNRKGDVTIF DCNSLQPVNV VEAHKTPLAC
210 220 230 240 250
LSLNSDGTLL ATASDKGTII RVFSVPKAQK LYEFRRGTYP AQIFSINFNL
260 270 280 290 300
ASNLMAVSSA TETVHIFQLE AGVSSTPEVP QDTELAIPTR TPQQKGMASV
310 320 330 340 350
FRKSSRSLGK GLAGAVGSYL PQTFTGMWEP LRDFAFIKQT SLPGTRSVVS
360 370 380 390 400
VTSTNPPQVL VVTLEGYFYQ YTLDLEKGGE CDLIRQYSLL DNVEGSLYGP
Length:400
Mass (Da):43,565
Last modified:August 16, 2004 - v1
Checksum:i1C14722C0F67BBC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG78780.1.
RefSeqiXP_505968.1. XM_505968.1.

Genome annotation databases

EnsemblFungiiCAG78780; CAG78780; YALI0_F27907g.
GeneIDi2908106.
KEGGiyli:YALI0F27907g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382132 Genomic DNA. Translation: CAG78780.1 .
RefSeqi XP_505968.1. XM_505968.1.

3D structure databases

ProteinModelPortali Q6C044.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6C044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG78780 ; CAG78780 ; YALI0_F27907g .
GeneIDi 2908106.
KEGGi yli:YALI0F27907g.

Phylogenomic databases

eggNOGi NOG317564.
HOGENOMi HOG000217543.
InParanoidi Q6C044.
KOi K17908.
OMAi VVHTIRD.
OrthoDBi EOG7BW0V3.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 2 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiATG18_YARLI
AccessioniPrimary (citable) accession number: Q6C044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3