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Q6BZH1

- GRP78_DEBHA

UniProt

Q6BZH1 - GRP78_DEBHA

Protein

78 kDa glucose-regulated protein homolog

Gene

KAR2

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Alternative name(s):
    Immunoglobulin heavy chain-binding protein homolog
    Short name:
    BIP
    Gene namesi
    Name:KAR2
    Ordered Locus Names:DEHA2A01364g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome A

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 68364978 kDa glucose-regulated protein homologPRO_0000013581Add
    BLAST

    Proteomic databases

    PRIDEiQ6BZH1.

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BZH1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BZH1.
    SMRiQ6BZH1. Positions 49-588.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi680 – 6834Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228135.
    KOiK09490.
    OMAiRDIKFLP.
    OrthoDBiEOG728916.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6BZH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKVNSRFWI SGFTLAYVLL AVILPLLTPN QGQALAAEGE TDNDTESYGT    50
    VIGIDLGTTY SCVGVMKNGK VEILANDQGN RITPSYVAFT PEERLIGDAA 100
    KNQASSNVEN TVFDIKRLIG LKYNDKMVQK EIKHLPYKID KKDGKPVVKV 150
    EFNDETKTFS PEEISGMILT KMKSIAEEYM GKKITHAVVT VPAYFNDAQR 200
    QATKDAGTIA GLNVLRIVNE PTAAAIAYGL DKTEGEKQII VYDLGGGTFD 250
    VSLLSIEGGV FEVLATAGDT HLGGEDFDFK VVRYLSSVFK KKHNIDISGN 300
    SKAISKLKRE TEKAKRTLSS QMSTRIEIDS FVDGIDFSET LSRAKFEELN 350
    IESFKKTLKP VQQVLKDAGF KKSDVDDIVL VGGSTRIPKV QELLEKFFDG 400
    KKASKGINPD EAVAYGAAVQ AGVLSGEEGV HDIVLLDVNP LTLGIETTGG 450
    VMTTLINRNT AIPTKKSQIF STAADNQPTV LIQVFEGERA LAKDNNKLGK 500
    FELTSIPPAP RGVPQIEVTF SLDANGILKV EAMDKGTGKS ESITITNDKG 550
    RLSKEDIDRM VEEAEKYAEQ DSELKAKIES RNSLENYAHM LKGQVKDESE 600
    NGLGSKLNDD DKETLDDAIK ETLEFIEDNY DSATSEEFEE QKQKLIDVAS 650
    PITSKLYGGG AGGADEAQFG DDDSDDEFVH DEL 683
    Length:683
    Mass (Da):74,585
    Last modified:August 16, 2004 - v1
    Checksum:i22CDC10E9EF3E479
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382133 Genomic DNA. Translation: CAG84345.1.
    RefSeqiXP_456398.1. XM_456398.1.

    Genome annotation databases

    GeneIDi2899287.
    KEGGidha:DEHA2A01364g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382133 Genomic DNA. Translation: CAG84345.1 .
    RefSeqi XP_456398.1. XM_456398.1.

    3D structure databases

    ProteinModelPortali Q6BZH1.
    SMRi Q6BZH1. Positions 49-588.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BZH1.

    Proteomic databases

    PRIDEi Q6BZH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2899287.
    KEGGi dha:DEHA2A01364g.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228135.
    KOi K09490.
    OMAi RDIKFLP.
    OrthoDBi EOG728916.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiGRP78_DEBHA
    AccessioniPrimary (citable) accession number: Q6BZH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3