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Q6BZH1

- GRP78_DEBHA

UniProt

Q6BZH1 - GRP78_DEBHA

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Protein
78 kDa glucose-regulated protein homolog
Gene
KAR2, DEHA2A01364g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BIP
Gene namesi
Name:KAR2
Ordered Locus Names:DEHA2A01364g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome A

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 68364978 kDa glucose-regulated protein homolog
PRO_0000013581Add
BLAST

Proteomic databases

PRIDEiQ6BZH1.

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BZH1.

Structurei

3D structure databases

ProteinModelPortaliQ6BZH1.
SMRiQ6BZH1. Positions 49-588.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi680 – 6834Prevents secretion from ER By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
KOiK09490.
OMAiRDIKFLP.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BZH1-1 [UniParc]FASTAAdd to Basket

« Hide

MLKVNSRFWI SGFTLAYVLL AVILPLLTPN QGQALAAEGE TDNDTESYGT    50
VIGIDLGTTY SCVGVMKNGK VEILANDQGN RITPSYVAFT PEERLIGDAA 100
KNQASSNVEN TVFDIKRLIG LKYNDKMVQK EIKHLPYKID KKDGKPVVKV 150
EFNDETKTFS PEEISGMILT KMKSIAEEYM GKKITHAVVT VPAYFNDAQR 200
QATKDAGTIA GLNVLRIVNE PTAAAIAYGL DKTEGEKQII VYDLGGGTFD 250
VSLLSIEGGV FEVLATAGDT HLGGEDFDFK VVRYLSSVFK KKHNIDISGN 300
SKAISKLKRE TEKAKRTLSS QMSTRIEIDS FVDGIDFSET LSRAKFEELN 350
IESFKKTLKP VQQVLKDAGF KKSDVDDIVL VGGSTRIPKV QELLEKFFDG 400
KKASKGINPD EAVAYGAAVQ AGVLSGEEGV HDIVLLDVNP LTLGIETTGG 450
VMTTLINRNT AIPTKKSQIF STAADNQPTV LIQVFEGERA LAKDNNKLGK 500
FELTSIPPAP RGVPQIEVTF SLDANGILKV EAMDKGTGKS ESITITNDKG 550
RLSKEDIDRM VEEAEKYAEQ DSELKAKIES RNSLENYAHM LKGQVKDESE 600
NGLGSKLNDD DKETLDDAIK ETLEFIEDNY DSATSEEFEE QKQKLIDVAS 650
PITSKLYGGG AGGADEAQFG DDDSDDEFVH DEL 683
Length:683
Mass (Da):74,585
Last modified:August 16, 2004 - v1
Checksum:i22CDC10E9EF3E479
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382133 Genomic DNA. Translation: CAG84345.1.
RefSeqiXP_456398.1. XM_456398.1.

Genome annotation databases

GeneIDi2899287.
KEGGidha:DEHA2A01364g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382133 Genomic DNA. Translation: CAG84345.1 .
RefSeqi XP_456398.1. XM_456398.1.

3D structure databases

ProteinModelPortali Q6BZH1.
SMRi Q6BZH1. Positions 49-588.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BZH1.

Proteomic databases

PRIDEi Q6BZH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2899287.
KEGGi dha:DEHA2A01364g.

Phylogenomic databases

eggNOGi COG0443.
HOGENOMi HOG000228135.
KOi K09490.
OMAi RDIKFLP.
OrthoDBi EOG728916.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiGRP78_DEBHA
AccessioniPrimary (citable) accession number: Q6BZH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi