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Protein

78 kDa glucose-regulated protein homolog

Gene

KAR2

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BIP
Gene namesi
Name:KAR2
Ordered Locus Names:DEHA2A01364g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome A

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 68364978 kDa glucose-regulated protein homologPRO_0000013581Add
BLAST

Proteomic databases

PRIDEiQ6BZH1.

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BZH1.

Structurei

3D structure databases

ProteinModelPortaliQ6BZH1.
SMRiQ6BZH1. Positions 49-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi680 – 6834Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiQ6BZH1.
KOiK09490.
OMAiKDKLAWI.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BZH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKVNSRFWI SGFTLAYVLL AVILPLLTPN QGQALAAEGE TDNDTESYGT
60 70 80 90 100
VIGIDLGTTY SCVGVMKNGK VEILANDQGN RITPSYVAFT PEERLIGDAA
110 120 130 140 150
KNQASSNVEN TVFDIKRLIG LKYNDKMVQK EIKHLPYKID KKDGKPVVKV
160 170 180 190 200
EFNDETKTFS PEEISGMILT KMKSIAEEYM GKKITHAVVT VPAYFNDAQR
210 220 230 240 250
QATKDAGTIA GLNVLRIVNE PTAAAIAYGL DKTEGEKQII VYDLGGGTFD
260 270 280 290 300
VSLLSIEGGV FEVLATAGDT HLGGEDFDFK VVRYLSSVFK KKHNIDISGN
310 320 330 340 350
SKAISKLKRE TEKAKRTLSS QMSTRIEIDS FVDGIDFSET LSRAKFEELN
360 370 380 390 400
IESFKKTLKP VQQVLKDAGF KKSDVDDIVL VGGSTRIPKV QELLEKFFDG
410 420 430 440 450
KKASKGINPD EAVAYGAAVQ AGVLSGEEGV HDIVLLDVNP LTLGIETTGG
460 470 480 490 500
VMTTLINRNT AIPTKKSQIF STAADNQPTV LIQVFEGERA LAKDNNKLGK
510 520 530 540 550
FELTSIPPAP RGVPQIEVTF SLDANGILKV EAMDKGTGKS ESITITNDKG
560 570 580 590 600
RLSKEDIDRM VEEAEKYAEQ DSELKAKIES RNSLENYAHM LKGQVKDESE
610 620 630 640 650
NGLGSKLNDD DKETLDDAIK ETLEFIEDNY DSATSEEFEE QKQKLIDVAS
660 670 680
PITSKLYGGG AGGADEAQFG DDDSDDEFVH DEL
Length:683
Mass (Da):74,585
Last modified:August 16, 2004 - v1
Checksum:i22CDC10E9EF3E479
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382133 Genomic DNA. Translation: CAG84345.1.
RefSeqiXP_456398.1. XM_456398.1.

Genome annotation databases

GeneIDi2899287.
KEGGidha:DEHA2A01364g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382133 Genomic DNA. Translation: CAG84345.1.
RefSeqiXP_456398.1. XM_456398.1.

3D structure databases

ProteinModelPortaliQ6BZH1.
SMRiQ6BZH1. Positions 49-588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4959.Q6BZH1.

Proteomic databases

PRIDEiQ6BZH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2899287.
KEGGidha:DEHA2A01364g.

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiQ6BZH1.
KOiK09490.
OMAiKDKLAWI.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRP78_DEBHA
AccessioniPrimary (citable) accession number: Q6BZH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.