Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6BZH1 (GRP78_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein homolog

Short name=GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name=BIP
Gene names
Name:KAR2
Ordered Locus Names:DEHA2A01364g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length683 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 68364978 kDa glucose-regulated protein homolog
PRO_0000013581

Regions

Motif680 – 6834Prevents secretion from ER By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BZH1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 22CDC10E9EF3E479

FASTA68374,585
        10         20         30         40         50         60 
MLKVNSRFWI SGFTLAYVLL AVILPLLTPN QGQALAAEGE TDNDTESYGT VIGIDLGTTY 

        70         80         90        100        110        120 
SCVGVMKNGK VEILANDQGN RITPSYVAFT PEERLIGDAA KNQASSNVEN TVFDIKRLIG 

       130        140        150        160        170        180 
LKYNDKMVQK EIKHLPYKID KKDGKPVVKV EFNDETKTFS PEEISGMILT KMKSIAEEYM 

       190        200        210        220        230        240 
GKKITHAVVT VPAYFNDAQR QATKDAGTIA GLNVLRIVNE PTAAAIAYGL DKTEGEKQII 

       250        260        270        280        290        300 
VYDLGGGTFD VSLLSIEGGV FEVLATAGDT HLGGEDFDFK VVRYLSSVFK KKHNIDISGN 

       310        320        330        340        350        360 
SKAISKLKRE TEKAKRTLSS QMSTRIEIDS FVDGIDFSET LSRAKFEELN IESFKKTLKP 

       370        380        390        400        410        420 
VQQVLKDAGF KKSDVDDIVL VGGSTRIPKV QELLEKFFDG KKASKGINPD EAVAYGAAVQ 

       430        440        450        460        470        480 
AGVLSGEEGV HDIVLLDVNP LTLGIETTGG VMTTLINRNT AIPTKKSQIF STAADNQPTV 

       490        500        510        520        530        540 
LIQVFEGERA LAKDNNKLGK FELTSIPPAP RGVPQIEVTF SLDANGILKV EAMDKGTGKS 

       550        560        570        580        590        600 
ESITITNDKG RLSKEDIDRM VEEAEKYAEQ DSELKAKIES RNSLENYAHM LKGQVKDESE 

       610        620        630        640        650        660 
NGLGSKLNDD DKETLDDAIK ETLEFIEDNY DSATSEEFEE QKQKLIDVAS PITSKLYGGG 

       670        680 
AGGADEAQFG DDDSDDEFVH DEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382133 Genomic DNA. Translation: CAG84345.1.
RefSeqXP_456398.1. XM_456398.1.

3D structure databases

ProteinModelPortalQ6BZH1.
SMRQ6BZH1. Positions 49-588.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BZH1.

Proteomic databases

PRIDEQ6BZH1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2899287.
KEGGdha:DEHA2A01364g.

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228135.
KOK09490.
OMARDIKFLP.
OrthoDBEOG728916.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_DEBHA
AccessionPrimary (citable) accession number: Q6BZH1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families