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Protein

D-arabinono-1,4-lactone oxidase

Gene

ALO1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathwayi: D-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-arabinono-1,4-lactone oxidase (ALO1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:ALO1
Ordered Locus Names:DEHA2A02904g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001281661 – 557D-arabinono-1,4-lactone oxidaseAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Pros-8alpha-FAD histidineBy similarity1

Structurei

3D structure databases

SMRiQ6BZA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 209FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000204635
InParanoidiQ6BZA0
KOiK00107
OMAiFRFLWFP
OrthoDBiEOG092C14O7

Family and domain databases

Gene3Di3.30.43.10, 1 hit
InterProiView protein in InterPro
IPR007173 ALO
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR010031 FAD_lactone_oxidase
IPR006094 Oxid_FAD_bind_N
IPR006093 Oxy_OxRdtase_FAD_BS
IPR030654 Sugar_lactone_oxidase
PANTHERiPTHR43762 PTHR43762, 1 hit
PfamiView protein in Pfam
PF04030 ALO, 1 hit
PF01565 FAD_binding_4, 1 hit
PIRSFiPIRSF000136 LGO_GLO, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR01678 FAD_lactone_ox, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit
PS00862 OX2_COVAL_FAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BZA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSDIPETLQ NFVSTKTVHQ TWAKTFFCKP QAIFQPRTVD EIRELVDQAR
60 70 80 90 100
INGKTIMTVG SGHSPSDMTM TKEWLCNLDR FNQVLKKEEF SGPTRNGEGE
110 120 130 140 150
EVKFVDLTVQ AGCRIYELNR YLKENELAIQ NLGSISDQSM AGVISTGTHG
160 170 180 190 200
STQYHGLVSQ QVVSIEIMNS AGKLITCSSM ENTQLFKAAM LSLGKIGIIT
210 220 230 240 250
HVTLRTIPKY TIKSKQEIIK FDTLLKNWDT VWLDSEFIRV WWFPYSGNCV
260 270 280 290 300
CWRASKSSEP LSKPRDSWYG TWFGRKFYES LLWISVHICP HLTPLIEKFV
310 320 330 340 350
FKNQYGDVET LGHGDVAVQN SVEGLNMDCL FSQFVNEWST PLSSGQDVLI
360 370 380 390 400
KLNDVIQTAR EQNRFYVHAP IEVRCSNLTY SEKPFVDEND EPSLYPNKKW
410 420 430 440 450
LAKRDRLSPG PIPGNNLRPY LDNSSNLRYD GDGANVTNDQ LTLFINATMY
460 470 480 490 500
RPFHTNVNSQ EWYQLFEDIM TNASGRPHWA KNFIGVNGAH RTDQDLRKQL
510 520 530 540 550
EFGGKTSYSM KGFNPILKKW FGENLVEYNK VRESMDPDNV FLSGKDWAVR

NGILIDV
Length:557
Mass (Da):63,709
Last modified:December 16, 2008 - v2
Checksum:iD2AEE1175CCECE73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382133 Genomic DNA Translation: CAG84421.2
RefSeqiXP_456469.2, XM_456469.1

Genome annotation databases

EnsemblFungiiCAG84421; CAG84421; DEHA2A02904g
GeneIDi2899772
KEGGidha:DEHA2A02904g

Similar proteinsi

Entry informationi

Entry nameiALO_DEBHA
AccessioniPrimary (citable) accession number: Q6BZA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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