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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:DEHA2A07854g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome A

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255608Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Protein-protein interaction databases

STRINGi4959.Q6BYP7.

Structurei

3D structure databases

ProteinModelPortaliQ6BYP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ6BYP7.
KOiK15544.
OMAiILEDQMM.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BYP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSDSLKICT VCAANNNRSM ESHKQLKDAG YNVRSFGTGS AVRLPGPSVD
60 70 80 90 100
KPNVYEFGTP YDDIYRDLTS QEYHKMYESN GLIRMINRNR HIKRAPEKWH
110 120 130 140 150
NNASAGKFDL VITCEERCFD LVLDDLMVRL VNKDQADTEI KQAVHIINID
160 170 180 190 200
IKDDYENAVI GGKGILKLVN MIHEFRNTNK QRRLDHDFDD ESDTILEDQM
210 220
MKLLAKWQQE HTHLPTLYSV AYY
Length:223
Mass (Da):25,813
Last modified:December 16, 2008 - v2
Checksum:i8F927BA73D58F7DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382133 Genomic DNA. Translation: CAG84628.2.
RefSeqiXP_456672.2. XM_456672.1.

Genome annotation databases

GeneIDi2899647.
KEGGidha:DEHA2A07854g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382133 Genomic DNA. Translation: CAG84628.2.
RefSeqiXP_456672.2. XM_456672.1.

3D structure databases

ProteinModelPortaliQ6BYP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4959.Q6BYP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2899647.
KEGGidha:DEHA2A07854g.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ6BYP7.
KOiK15544.
OMAiILEDQMM.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSU72_DEBHA
AccessioniPrimary (citable) accession number: Q6BYP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 16, 2008
Last modified: January 7, 2015
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.