Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:DEHA2A07854g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002556081 – 223RNA polymerase II subunit A C-terminal domain phosphatase SSU72Add BLAST223

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BYP7
SMRiQ6BYP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

HOGENOMiHOG000183445
InParanoidiQ6BYP7
KOiK15544
OMAiWQERWPN
OrthoDBiEOG092C4UKX

Family and domain databases

InterProiView protein in InterPro
IPR006811 RNA_pol_II_suA
PANTHERiPTHR20383 PTHR20383, 1 hit
PfamiView protein in Pfam
PF04722 Ssu72, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BYP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSDSLKICT VCAANNNRSM ESHKQLKDAG YNVRSFGTGS AVRLPGPSVD
60 70 80 90 100
KPNVYEFGTP YDDIYRDLTS QEYHKMYESN GLIRMINRNR HIKRAPEKWH
110 120 130 140 150
NNASAGKFDL VITCEERCFD LVLDDLMVRL VNKDQADTEI KQAVHIINID
160 170 180 190 200
IKDDYENAVI GGKGILKLVN MIHEFRNTNK QRRLDHDFDD ESDTILEDQM
210 220
MKLLAKWQQE HTHLPTLYSV AYY
Length:223
Mass (Da):25,813
Last modified:December 16, 2008 - v2
Checksum:i8F927BA73D58F7DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382133 Genomic DNA Translation: CAG84628.2
RefSeqiXP_456672.2, XM_456672.1

Genome annotation databases

EnsemblFungiiCAG84628; CAG84628; DEHA2A07854g
GeneIDi2899647
KEGGidha:DEHA2A07854g

Similar proteinsi

Entry informationi

Entry nameiSSU72_DEBHA
AccessioniPrimary (citable) accession number: Q6BYP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 16, 2008
Last modified: April 25, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health