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Q6BYP7

- SSU72_DEBHA

UniProt

Q6BYP7 - SSU72_DEBHA

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Protein
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Gene
SSU72, DEHA2A07854g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1) By similarity.
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:DEHA2A07854g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome A

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223RNA polymerase II subunit A C-terminal domain phosphatase SSU72
PRO_0000255608Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Protein-protein interaction databases

STRINGi4959.Q6BYP7.

Structurei

3D structure databases

ProteinModelPortaliQ6BYP7.

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
KOiK15544.
OMAiMAKSNDI.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BYP7-1 [UniParc]FASTAAdd to Basket

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MVSDSLKICT VCAANNNRSM ESHKQLKDAG YNVRSFGTGS AVRLPGPSVD    50
KPNVYEFGTP YDDIYRDLTS QEYHKMYESN GLIRMINRNR HIKRAPEKWH 100
NNASAGKFDL VITCEERCFD LVLDDLMVRL VNKDQADTEI KQAVHIINID 150
IKDDYENAVI GGKGILKLVN MIHEFRNTNK QRRLDHDFDD ESDTILEDQM 200
MKLLAKWQQE HTHLPTLYSV AYY 223
Length:223
Mass (Da):25,813
Last modified:December 16, 2008 - v2
Checksum:i8F927BA73D58F7DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382133 Genomic DNA. Translation: CAG84628.2.
RefSeqiXP_456672.2. XM_456672.1.

Genome annotation databases

GeneIDi2899647.
KEGGidha:DEHA2A07854g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382133 Genomic DNA. Translation: CAG84628.2 .
RefSeqi XP_456672.2. XM_456672.1.

3D structure databases

ProteinModelPortali Q6BYP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BYP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2899647.
KEGGi dha:DEHA2A07854g.

Phylogenomic databases

eggNOGi COG5211.
HOGENOMi HOG000183445.
KOi K15544.
OMAi MAKSNDI.
OrthoDBi EOG7GTTG0.

Family and domain databases

InterProi IPR006811. RNA_pol_II_suA.
[Graphical view ]
PANTHERi PTHR20383. PTHR20383. 1 hit.
Pfami PF04722. Ssu72. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSSU72_DEBHA
AccessioniPrimary (citable) accession number: Q6BYP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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