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Protein

Histone deacetylase

Gene

DEHA2A08712g

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124SubstrateUniRule annotation1
Active sitei166Proton acceptorUniRule annotation1
Binding sitei174Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi201Divalent metal cationUniRule annotation1
Metal bindingi203Divalent metal cationUniRule annotation1
Metal bindingi290Divalent metal cationUniRule annotation1
Binding sitei329SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:DEHA2A08712gImported
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)Imported
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ6BYL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 345Hist_deacetylInterPro annotationAdd BLAST294

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiQ6BYL2.
KOiK11483.
OMAiPRAWTHL.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6BYL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPANQSPT FTKDKKTQEN TPLYLANSTS KLPNVSYHYN PQVSQYHFGP
60 70 80 90 100
HHPMKPFRLM LTDHLVISYK LYEQMDLYTP RRATKEELLE FHAEDYIDFL
110 120 130 140 150
QTITPEKTLK MSDQKLAQFN IGDDCPVFDG IYDYSSIYAG ASLDASRKLI
160 170 180 190 200
SGMSDIAINW SGGLHHAKKF EPSGFCYVND IVLSIINLLR VHPRVMYIDI
210 220 230 240 250
DLHHGDGVQE AFYVTDRVMT VSFHKYNGEF FPGTGSVDET GLGKGKNYAV
260 270 280 290 300
NVPLKDGIDD DSYIRLFKSI MEPLITKFQP TCIVQQCGAD SLGYDRLGCF
310 320 330 340 350
NLNIRAHGEC VKYIKSFGIP MLVLGGGGYT PRNVSRLWCY ETSVLNDVTL
360 370 380 390 400
DHTIPNYLPT HDWFGPDYSL HPQLDGRIDN KNSKKYLESV KQEVLEQLRY
410 420 430 440 450
LTYAPSVQMQ EIPPDITGLT EEEEDIIKEL NSMNDDKDVR IMKNIKDEAR

SSEMVN
Length:456
Mass (Da):51,967
Last modified:November 4, 2008 - v2
Checksum:iAA42CC429615F8AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382133 Genomic DNA. Translation: CAG84663.2.
RefSeqiXP_456707.2. XM_456707.1.

Genome annotation databases

EnsemblFungiiCAG84663; CAG84663; DEHA2A08712g.
GeneIDi2899758.
KEGGidha:DEHA2A08712g.

Similar proteinsi

Entry informationi

Entry nameiQ6BYL2_DEBHA
AccessioniPrimary (citable) accession number: Q6BYL2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: November 4, 2008
Last modified: November 22, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported