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Q6BY69

- PYRF_DEBHA

UniProt

Q6BY69 - PYRF_DEBHA

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateBy similarity
    Active sitei94 – 941Proton donorPROSITE-ProRule annotation
    Binding sitei218 – 2181SubstrateBy similarity
    Binding sitei236 – 2361SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    Ordered Locus Names:DEHA2A11968g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome A

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Orotidine 5'-phosphate decarboxylasePRO_0000134658Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BY69.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BY69.
    SMRiQ6BY69. Positions 6-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 623Substrate bindingBy similarity
    Regioni92 – 10110Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000213905.
    KOiK01591.
    OMAiMGQQYRT.
    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6BY69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKTQTYTER ASAHPSPVAQ RLFKLMDNKK TNLCASVDVK STEEFLTLIE    50
    KLGPYICLVK THIDIIDDFS YEGTVVPLLA LAKKHNFMIF EDRKFADIGN 100
    TVKSQYSGGV YKIAQWSDIT NAHGITGSGI VKGLKEAAQE SSKEPRGLLM 150
    LAELSSKGSL AYGEYTEKTI EIAKSDKEFV IGFIAQRDMG GTDEGFDWIV 200
    MTPGVGLDDK GDGLGQQYRT VDQVVTTGTD IIIVGRGLFG QGRDPTVEGK 250
    RYRDAGWNAY LKKTGSL 267
    Length:267
    Mass (Da):29,320
    Last modified:August 16, 2004 - v1
    Checksum:iD999613C57D2BEE0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 42KT → NK in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti28 – 281N → S in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti43 – 431E → D in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti50 – 501E → D in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti69 – 691F → Y in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti75 – 762VV → II in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti141 – 1433SSK → VSS in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti167 – 1682EK → GL in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti192 – 1921T → S in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti200 – 2001V → I in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti223 – 2231Q → E in AAK54442. (PubMed:11571754)Curated
    Sequence conflicti226 – 2261T → S in AAK54442. (PubMed:11571754)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033329 Genomic DNA. Translation: AAK54442.1.
    CR382133 Genomic DNA. Translation: CAG84825.1.
    RefSeqiXP_456850.1. XM_456850.1.

    Genome annotation databases

    GeneIDi2899491.
    KEGGidha:DEHA2A11968g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033329 Genomic DNA. Translation: AAK54442.1 .
    CR382133 Genomic DNA. Translation: CAG84825.1 .
    RefSeqi XP_456850.1. XM_456850.1.

    3D structure databases

    ProteinModelPortali Q6BY69.
    SMRi Q6BY69. Positions 6-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BY69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2899491.
    KEGGi dha:DEHA2A11968g.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000213905.
    KOi K01591.
    OMAi MGQQYRT.
    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A minisatellite sequence in the upstream region of DURA3 gene from halotolerant yeast Debaryomyces hansenii."
      Bansal P.K., Sharma P., Mondal A.K.
      Yeast 18:1301-1307(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MTCC 234.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

    Entry informationi

    Entry nameiPYRF_DEBHA
    AccessioniPrimary (citable) accession number: Q6BY69
    Secondary accession number(s): Q96VQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3