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Q6BY69

- PYRF_DEBHA

UniProt

Q6BY69 - PYRF_DEBHA

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381SubstrateBy similarity
Active sitei94 – 941Proton donorPROSITE-ProRule annotation
Binding sitei218 – 2181SubstrateBy similarity
Binding sitei236 – 2361SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
Ordered Locus Names:DEHA2A11968g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome A

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Orotidine 5'-phosphate decarboxylasePRO_0000134658Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BY69.

Structurei

3D structure databases

ProteinModelPortaliQ6BY69.
SMRiQ6BY69. Positions 6-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 623Substrate bindingBy similarity
Regioni92 – 10110Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
InParanoidiQ6BY69.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BY69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKTQTYTER ASAHPSPVAQ RLFKLMDNKK TNLCASVDVK STEEFLTLIE
60 70 80 90 100
KLGPYICLVK THIDIIDDFS YEGTVVPLLA LAKKHNFMIF EDRKFADIGN
110 120 130 140 150
TVKSQYSGGV YKIAQWSDIT NAHGITGSGI VKGLKEAAQE SSKEPRGLLM
160 170 180 190 200
LAELSSKGSL AYGEYTEKTI EIAKSDKEFV IGFIAQRDMG GTDEGFDWIV
210 220 230 240 250
MTPGVGLDDK GDGLGQQYRT VDQVVTTGTD IIIVGRGLFG QGRDPTVEGK
260
RYRDAGWNAY LKKTGSL
Length:267
Mass (Da):29,320
Last modified:August 16, 2004 - v1
Checksum:iD999613C57D2BEE0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42KT → NK in AAK54442. (PubMed:11571754)Curated
Sequence conflicti28 – 281N → S in AAK54442. (PubMed:11571754)Curated
Sequence conflicti43 – 431E → D in AAK54442. (PubMed:11571754)Curated
Sequence conflicti50 – 501E → D in AAK54442. (PubMed:11571754)Curated
Sequence conflicti69 – 691F → Y in AAK54442. (PubMed:11571754)Curated
Sequence conflicti75 – 762VV → II in AAK54442. (PubMed:11571754)Curated
Sequence conflicti141 – 1433SSK → VSS in AAK54442. (PubMed:11571754)Curated
Sequence conflicti167 – 1682EK → GL in AAK54442. (PubMed:11571754)Curated
Sequence conflicti192 – 1921T → S in AAK54442. (PubMed:11571754)Curated
Sequence conflicti200 – 2001V → I in AAK54442. (PubMed:11571754)Curated
Sequence conflicti223 – 2231Q → E in AAK54442. (PubMed:11571754)Curated
Sequence conflicti226 – 2261T → S in AAK54442. (PubMed:11571754)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033329 Genomic DNA. Translation: AAK54442.1.
CR382133 Genomic DNA. Translation: CAG84825.1.
RefSeqiXP_456850.1. XM_456850.1.

Genome annotation databases

GeneIDi2899491.
KEGGidha:DEHA2A11968g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033329 Genomic DNA. Translation: AAK54442.1 .
CR382133 Genomic DNA. Translation: CAG84825.1 .
RefSeqi XP_456850.1. XM_456850.1.

3D structure databases

ProteinModelPortali Q6BY69.
SMRi Q6BY69. Positions 6-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BY69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2899491.
KEGGi dha:DEHA2A11968g.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000213905.
InParanoidi Q6BY69.
KOi K01591.
OMAi MGQQYRT.
OrthoDBi EOG7CVQ76.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A minisatellite sequence in the upstream region of DURA3 gene from halotolerant yeast Debaryomyces hansenii."
    Bansal P.K., Sharma P., Mondal A.K.
    Yeast 18:1301-1307(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MTCC 234.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Entry informationi

Entry nameiPYRF_DEBHA
AccessioniPrimary (citable) accession number: Q6BY69
Secondary accession number(s): Q96VQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3