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Q6BY69 (PYRF_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
Ordered Locus Names:DEHA2A11968g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Orotidine 5'-phosphate decarboxylase
PRO_0000134658

Regions

Region60 – 623Substrate binding By similarity
Region92 – 10110Substrate binding By similarity

Sites

Active site941Proton donor By similarity
Binding site381Substrate By similarity
Binding site2181Substrate By similarity
Binding site2361Substrate By similarity

Experimental info

Sequence conflict3 – 42KT → NK in AAK54442. Ref.1
Sequence conflict281N → S in AAK54442. Ref.1
Sequence conflict431E → D in AAK54442. Ref.1
Sequence conflict501E → D in AAK54442. Ref.1
Sequence conflict691F → Y in AAK54442. Ref.1
Sequence conflict75 – 762VV → II in AAK54442. Ref.1
Sequence conflict141 – 1433SSK → VSS in AAK54442. Ref.1
Sequence conflict167 – 1682EK → GL in AAK54442. Ref.1
Sequence conflict1921T → S in AAK54442. Ref.1
Sequence conflict2001V → I in AAK54442. Ref.1
Sequence conflict2231Q → E in AAK54442. Ref.1
Sequence conflict2261T → S in AAK54442. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6BY69 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: D999613C57D2BEE0

FASTA26729,320
        10         20         30         40         50         60 
MVKTQTYTER ASAHPSPVAQ RLFKLMDNKK TNLCASVDVK STEEFLTLIE KLGPYICLVK 

        70         80         90        100        110        120 
THIDIIDDFS YEGTVVPLLA LAKKHNFMIF EDRKFADIGN TVKSQYSGGV YKIAQWSDIT 

       130        140        150        160        170        180 
NAHGITGSGI VKGLKEAAQE SSKEPRGLLM LAELSSKGSL AYGEYTEKTI EIAKSDKEFV 

       190        200        210        220        230        240 
IGFIAQRDMG GTDEGFDWIV MTPGVGLDDK GDGLGQQYRT VDQVVTTGTD IIIVGRGLFG 

       250        260 
QGRDPTVEGK RYRDAGWNAY LKKTGSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY033329 Genomic DNA. Translation: AAK54442.1.
CR382133 Genomic DNA. Translation: CAG84825.1.
RefSeqXP_456850.1. XM_456850.1.

3D structure databases

ProteinModelPortalQ6BY69.
SMRQ6BY69. Positions 6-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BY69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2899491.
KEGGdha:DEHA2A11968g.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000213905.
KOK01591.
OMAMGQQYRT.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_DEBHA
AccessionPrimary (citable) accession number: Q6BY69
Secondary accession number(s): Q96VQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways