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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Orotidine 5'-phosphate decarboxylase (URA3)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateBy similarity1
Active sitei94Proton donorPROSITE-ProRule annotation1
Binding sitei218SubstrateBy similarity1
Binding sitei236SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
Ordered Locus Names:DEHA2A11968g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome A

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346581 – 267Orotidine 5'-phosphate decarboxylaseAdd BLAST267

Structurei

3D structure databases

ProteinModelPortaliQ6BY69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 62Substrate bindingBy similarity3
Regioni92 – 101Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

HOGENOMiHOG000213905.
InParanoidiQ6BY69.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG092C3SZ1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BY69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKTQTYTER ASAHPSPVAQ RLFKLMDNKK TNLCASVDVK STEEFLTLIE
60 70 80 90 100
KLGPYICLVK THIDIIDDFS YEGTVVPLLA LAKKHNFMIF EDRKFADIGN
110 120 130 140 150
TVKSQYSGGV YKIAQWSDIT NAHGITGSGI VKGLKEAAQE SSKEPRGLLM
160 170 180 190 200
LAELSSKGSL AYGEYTEKTI EIAKSDKEFV IGFIAQRDMG GTDEGFDWIV
210 220 230 240 250
MTPGVGLDDK GDGLGQQYRT VDQVVTTGTD IIIVGRGLFG QGRDPTVEGK
260
RYRDAGWNAY LKKTGSL
Length:267
Mass (Da):29,320
Last modified:August 16, 2004 - v1
Checksum:iD999613C57D2BEE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4KT → NK in AAK54442 (PubMed:11571754).Curated2
Sequence conflicti28N → S in AAK54442 (PubMed:11571754).Curated1
Sequence conflicti43E → D in AAK54442 (PubMed:11571754).Curated1
Sequence conflicti50E → D in AAK54442 (PubMed:11571754).Curated1
Sequence conflicti69F → Y in AAK54442 (PubMed:11571754).Curated1
Sequence conflicti75 – 76VV → II in AAK54442 (PubMed:11571754).Curated2
Sequence conflicti141 – 143SSK → VSS in AAK54442 (PubMed:11571754).Curated3
Sequence conflicti167 – 168EK → GL in AAK54442 (PubMed:11571754).Curated2
Sequence conflicti192T → S in AAK54442 (PubMed:11571754).Curated1
Sequence conflicti200V → I in AAK54442 (PubMed:11571754).Curated1
Sequence conflicti223Q → E in AAK54442 (PubMed:11571754).Curated1
Sequence conflicti226T → S in AAK54442 (PubMed:11571754).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033329 Genomic DNA. Translation: AAK54442.1.
CR382133 Genomic DNA. Translation: CAG84825.1.
RefSeqiXP_456850.1. XM_456850.1.

Genome annotation databases

EnsemblFungiiCAG84825; CAG84825; DEHA2A11968g.
GeneIDi2899491.
KEGGidha:DEHA2A11968g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033329 Genomic DNA. Translation: AAK54442.1.
CR382133 Genomic DNA. Translation: CAG84825.1.
RefSeqiXP_456850.1. XM_456850.1.

3D structure databases

ProteinModelPortaliQ6BY69.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG84825; CAG84825; DEHA2A11968g.
GeneIDi2899491.
KEGGidha:DEHA2A11968g.

Phylogenomic databases

HOGENOMiHOG000213905.
InParanoidiQ6BY69.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG092C3SZ1.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRF_DEBHA
AccessioniPrimary (citable) accession number: Q6BY69
Secondary accession number(s): Q96VQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 16, 2004
Last modified: October 5, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.