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Q6BXJ4 (JHD1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
JmjC domain-containing histone demethylation protein 1
EC=1.14.11.27
Alternative name(s):
[Histone-H3]-lysine-36 demethylase 1
Gene names
Name:JHD1
Ordered Locus Names:DEHA2B02464g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.

Catalytic activity

Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2.

Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subcellular location

Nucleus By similarity.

Domain

The JmjC domain mediates the demethylation activity By similarity.

Sequence similarities

Belongs to the JHDM1 histone demethylase family.

Contains 1 JmjC domain.

Contains 1 PHD-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514JmjC domain-containing histone demethylation protein 1
PRO_0000226796

Regions

Domain220 – 384165JmjC
Zinc finger4 – 6259PHD-type

Sites

Metal binding2701Iron; catalytic By similarity
Metal binding2721Iron; catalytic By similarity
Metal binding3521Iron; catalytic By similarity
Binding site2671Substrate By similarity
Binding site2871Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BXJ4 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 44B4D3E3EF349156

FASTA51458,685
        10         20         30         40         50         60 
MPDIDTCPIC VESPLEDSTT FNNIAWLQCD ICNQWFHASC LKIPKIEVNN LHSYHCEGCS 

        70         80         90        100        110        120 
KSHGPSIPKR KSKRSKVQID YVALNDGDVF AVDKSSHPHV DKFLSFEVNA NEIDDKINPY 

       130        140        150        160        170        180 
IDFRKDITAD YALDTRLTRP VLIPRADLDI VDMKLPIEGK EITIDYIANE VGDDTPLDVM 

       190        200        210        220        230        240 
DVLTQQGVNP GWNLGKWRDY YNTDELSRDR IRNVISLEIS DVDSFGKSFR RPRIVRDMDL 

       250        260        270        280        290        300 
VDKVWNDKSP RPKVTKYCLM SVTGSFTDFH IDFSGTSVYY TVCSGSKTFL MYPPTEQNLD 

       310        320        330        340        350        360 
IYTSWCLQPD QNYMWFGDFT KAFKGKGCTP SGGFKVTLSP GDLFIIPSGW IHAVFTPEDS 

       370        380        390        400        410        420 
LVIGGNFLTL MDLSMHLRIY EIEKVTRVPA KFRFPMFNRV LWLTSWYYYN NKSQFLKDLG 

       430        440        450        460        470        480 
QDAHIKNEAH IKSEAHSRGE VHTKTETHAV KDEPQPDQSV QYKTLSCLVS HLQSHYESSK 

       490        500        510 
INKVARNTIP AGLIGKDIPG YLAKLQSWLD ELSP

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382134 Genomic DNA. Translation: CAG85063.2.
RefSeqXP_457075.2. XM_457075.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2913011.
GenomeReviewsGene locus DEHA2B02464g in contig CR382134_GR.
KEGGdha:DEHA2B02464g.

Phylogenomic databases

eggNOGfuNOG04730.
HOGENOMHBG398146.
OMAQSETFFG.
OrthoDBEOG4SXRNC.

Family and domain databases

InterProIPR014710. RmlC-like_jellyroll.
IPR013129. TF_JmjC.
IPR003347. TF_JmjC_AAH.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
Gene3DG3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KOK10276.
PfamPF02373. JmjC. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITEPS51184. JMJC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJHD1_DEBHA
AccessionPrimary (citable) accession number: Q6BXJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 16, 2008
Last modified: November 16, 2011
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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