Reviewed, UniProtKB/Swiss-Prot Q6BXJ4 (JHD1_DEBHA)

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1

Gene names

Name:	JHD1
Ordered Locus Names:	DEHA2B02464g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.
Catalytic activity	Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.
Cofactor	Binds 1 Fe2+ ion per subunit By similarity.
Subcellular location	Nucleus By similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain. Contains 1 PHD-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 514	514	JmjC domain-containing histone demethylation protein 1		PRO_0000226796
Regions
	Domain	220 – 384	165	JmjC
	Zinc finger	4 – 62	59	PHD-type
Sites
	Metal binding	270	1	Iron; catalytic By similarity
	Metal binding	272	1	Iron; catalytic By similarity
	Metal binding	352	1	Iron; catalytic By similarity
	Binding site	267	1	Substrate By similarity
	Binding site	287	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6BXJ4-1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 44B4D3E3EF349156	FASTA	514	58,685
	10 20 30 40 50 60 MPDIDTCPIC VESPLEDSTT FNNIAWLQCD ICNQWFHASC LKIPKIEVNN LHSYHCEGCS 70 80 90 100 110 120 KSHGPSIPKR KSKRSKVQID YVALNDGDVF AVDKSSHPHV DKFLSFEVNA NEIDDKINPY 130 140 150 160 170 180 IDFRKDITAD YALDTRLTRP VLIPRADLDI VDMKLPIEGK EITIDYIANE VGDDTPLDVM 190 200 210 220 230 240 DVLTQQGVNP GWNLGKWRDY YNTDELSRDR IRNVISLEIS DVDSFGKSFR RPRIVRDMDL 250 260 270 280 290 300 VDKVWNDKSP RPKVTKYCLM SVTGSFTDFH IDFSGTSVYY TVCSGSKTFL MYPPTEQNLD 310 320 330 340 350 360 IYTSWCLQPD QNYMWFGDFT KAFKGKGCTP SGGFKVTLSP GDLFIIPSGW IHAVFTPEDS 370 380 390 400 410 420 LVIGGNFLTL MDLSMHLRIY EIEKVTRVPA KFRFPMFNRV LWLTSWYYYN NKSQFLKDLG 430 440 450 460 470 480 QDAHIKNEAH IKSEAHSRGE VHTKTETHAV KDEPQPDQSV QYKTLSCLVS HLQSHYESSK 490 500 510 INKVARNTIP AGLIGKDIPG YLAKLQSWLD ELSP

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382134 Genomic DNA. Translation: CAG85063.2.
RefSeq	XP_457075.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2913011.
KEGG	dha:DEHA0B02519g.
Phylogenomic databases
HOGENOM	Q6BXJ4.
OMA	Q6BXJ4. SRDRIRN.
Enzyme and pathway databases
BRENDA	1.14.11.27. 74267.
Family and domain databases
InterPro	IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR019786. Zinc_finger_PHD-type_CS. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view]
Pfam	PF02373. JmjC. 1 hit. PF00628. PHD. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

JHD1_DEBHA

Accession

Primary (citable) accession number: Q6BXJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	December 16, 2008
Last modified:	June 16, 2009
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)