Q6BXD7 (ATM1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial

Gene names

Name:	ATM1
Ordered Locus Names:	DEHA2B03894g

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

284592 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces › Debaryomyces hansenii › Debaryomyces hansenii var. hansenii

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors from the mitochondrion By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	ATP-binding Iron Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC ion transport Inferred from electronic annotation. Source: UniProtKB-KW iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 67	67	Mitochondrion Potential
	Chain	68 – 696	629	Iron-sulfur clusters transporter ATM1, mitochondrial		PRO_0000255444
Regions
	Topological domain	68 – 110	43	Mitochondrial matrix Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Topological domain	132 – 149	18	Mitochondrial intermembrane Potential
	Transmembrane	150 – 170	21	Helical; Potential
	Topological domain	171 – 229	59	Mitochondrial matrix Potential
	Transmembrane	230 – 250	21	Helical; Potential
	Topological domain	251 – 252	2	Mitochondrial intermembrane Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Topological domain	274 – 346	73	Mitochondrial matrix Potential
	Transmembrane	347 – 367	21	Helical; Potential
	Topological domain	368 – 696	329	Mitochondrial intermembrane Potential
	Domain	110 – 400	291	ABC transmembrane type-1
	Domain	438 – 674	237	ABC transporter
	Nucleotide binding	471 – 478	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6BXD7 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: B052D8AA8F45A07F	FASTA	696	77,475
	10 20 30 40 50 60 MIKWGLFGAV KPFRSMVPLS QTRSLIISKS SLVRSKRVST IRPQLAPVNP YSKIYGRRFF 70 80 90 100 110 120 SSSHKLGVNT KEDSSTYLFG RKISTSESKM LKSLLVTIWP KNKPSFKLRV IFALSLLIAS 130 140 150 160 170 180 KLLNVEVPFF FKKIIDEMNV DWNDQLGTVG TVIGTLIIAY GGARFGAVLF GELRNAVFAS 190 200 210 220 230 240 VAQTAIKRVA HNTFVHLLNM DLNFHLSRQT GGLTRAIDRG TKGISYVLNA MVFHIIPISF 250 260 270 280 290 300 EISMVCGILI YNYGLSFAAV TLATMLSYSV FTIKTTAWRT GFRRQANNAD NQAATVALDS 310 320 330 340 350 360 LLNYESVKYF NNEGFQASKY NTALTNYQNA SVKVATSLAY LNAGQNFIFT SALTAMMYMG 370 380 390 400 410 420 CNGVATGSLT VGDLVLINQL VFQLSVPLSF LGSVYRELKQ SLLDMENLFQ LQNHEIKIKD 430 440 450 460 470 480 ASNAKPLLLN STGVPGEIKF ENVTFGYHPD RPILQNASFT IPAGEKIAIV GPSGSGKSTI 490 500 510 520 530 540 LRLIFRFYDV ESGKIFIDGQ DISKVTVESL RRSIGIVPQD TPLFNDTILE NIRYGRLDAT 550 560 570 580 590 600 DKEIHEMIDK VQLTKLIEDS PNGVNTIVGE RGMMISGGEK QRLAIARLLL KRAPITLFDE 610 620 630 640 650 660 ATSALDTHTE QSLLRTIRKV LTKKANTHIA IAHRLRTIAD ADKIIVLNKG QVQEEGTHHN 670 680 690 LLQNPNSLYS QLWNIQENLD IDEELNEYAK ETEEQK

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382134 Genomic DNA. Translation: CAG85125.2.
RefSeq	XP_457132.2. XM_457132.1.
3D structure databases
HSSP	HSSP built from PDB template 2GHI based on UniProtKB Q7RBT4.
ProteinModelPortal	Q6BXD7.
ModBase	Search...
Protein-protein interaction databases
STRING	4959.Q6BXD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2913198.
KEGG	dha:DEHA2B03894g.
Phylogenomic databases
eggNOG	COG5265.
KO	K05663.
OMA	RYEAQRY.
OrthoDB	EOG483HCT.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATM1_DEBHA

Accession

Primary (citable) accession number: Q6BXD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program