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Protein

Iron-sulfur clusters transporter ATM1, mitochondrial

Gene

ATM1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei392Glutathione; via amide nitrogenBy similarity1
Binding sitei447ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi471 – 482ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial
Gene namesi
Name:ATM1
Ordered Locus Names:DEHA2B03894g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome B

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini68 – 109Mitochondrial matrixBy similarityAdd BLAST42
Transmembranei110 – 131HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini132 – 154Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei155 – 178HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini179 – 227Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei228 – 251HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini252Mitochondrial intermembraneBy similarity1
Transmembranei253 – 273HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini274 – 339Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei340 – 358HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini359 – 373Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei374 – 395HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini396 – 696Mitochondrial matrixBy similarityAdd BLAST301

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 67MitochondrionSequence analysisAdd BLAST67
ChainiPRO_000025544468 – 696Iron-sulfur clusters transporter ATM1, mitochondrialAdd BLAST629

Proteomic databases

PRIDEiQ6BXD7.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BXD7.
SMRiQ6BXD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 400ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini438 – 674ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 283Glutathione bindingBy similarity5
Regioni342 – 345Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ6BXD7.
KOiK05663.
OMAiYEAQRYD.
OrthoDBiEOG092C3H79.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BXD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKWGLFGAV KPFRSMVPLS QTRSLIISKS SLVRSKRVST IRPQLAPVNP
60 70 80 90 100
YSKIYGRRFF SSSHKLGVNT KEDSSTYLFG RKISTSESKM LKSLLVTIWP
110 120 130 140 150
KNKPSFKLRV IFALSLLIAS KLLNVEVPFF FKKIIDEMNV DWNDQLGTVG
160 170 180 190 200
TVIGTLIIAY GGARFGAVLF GELRNAVFAS VAQTAIKRVA HNTFVHLLNM
210 220 230 240 250
DLNFHLSRQT GGLTRAIDRG TKGISYVLNA MVFHIIPISF EISMVCGILI
260 270 280 290 300
YNYGLSFAAV TLATMLSYSV FTIKTTAWRT GFRRQANNAD NQAATVALDS
310 320 330 340 350
LLNYESVKYF NNEGFQASKY NTALTNYQNA SVKVATSLAY LNAGQNFIFT
360 370 380 390 400
SALTAMMYMG CNGVATGSLT VGDLVLINQL VFQLSVPLSF LGSVYRELKQ
410 420 430 440 450
SLLDMENLFQ LQNHEIKIKD ASNAKPLLLN STGVPGEIKF ENVTFGYHPD
460 470 480 490 500
RPILQNASFT IPAGEKIAIV GPSGSGKSTI LRLIFRFYDV ESGKIFIDGQ
510 520 530 540 550
DISKVTVESL RRSIGIVPQD TPLFNDTILE NIRYGRLDAT DKEIHEMIDK
560 570 580 590 600
VQLTKLIEDS PNGVNTIVGE RGMMISGGEK QRLAIARLLL KRAPITLFDE
610 620 630 640 650
ATSALDTHTE QSLLRTIRKV LTKKANTHIA IAHRLRTIAD ADKIIVLNKG
660 670 680 690
QVQEEGTHHN LLQNPNSLYS QLWNIQENLD IDEELNEYAK ETEEQK
Length:696
Mass (Da):77,475
Last modified:December 16, 2008 - v2
Checksum:iB052D8AA8F45A07F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382134 Genomic DNA. Translation: CAG85125.2.
RefSeqiXP_457132.2. XM_457132.1.

Genome annotation databases

EnsemblFungiiCAG85125; CAG85125; DEHA2B03894g.
GeneIDi2913198.
KEGGidha:DEHA2B03894g.

Similar proteinsi

Entry informationi

Entry nameiATM1_DEBHA
AccessioniPrimary (citable) accession number: Q6BXD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 16, 2008
Last modified: June 7, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families