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Q6BX71

- HEM1_DEBHA

UniProt

Q6BX71 - HEM1_DEBHA

Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241SubstrateBy similarity
    Binding sitei237 – 2371SubstrateBy similarity
    Binding sitei256 – 2561SubstrateBy similarity
    Binding sitei289 – 2891Pyridoxal phosphateBy similarity
    Binding sitei317 – 3171Pyridoxal phosphateBy similarity
    Binding sitei361 – 3611Pyridoxal phosphateBy similarity
    Active sitei364 – 3641By similarity
    Binding sitei393 – 3931Pyridoxal phosphateBy similarity
    Binding sitei394 – 3941Pyridoxal phosphateBy similarity
    Binding sitei479 – 4791SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:HEM1
    Ordered Locus Names:DEHA2B05478g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome B

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 5755-aminolevulinate synthase, mitochondrialPRO_0000001239
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei364 – 3641N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BX71.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BX71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    KOiK00643.
    OMAiKLAQYPK.
    OrthoDBiEOG7HHX1P.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6BX71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESITRVSMS VCPFVKSSSA QALRQLSKNS ALTSQARQCP FMGAALNAKE    50
    STRSYSSATK PVRATASSLA SNPPSTMQSK YSFKAEELVG NKDAINLESK 100
    ENTFDFKGYL NSELSKKRTD KSYRFFNNIN RLANEFPKAH RSEENDKVTV 150
    WCSNDYLGMG KNENTINEMK RVLTKYGSGA GGTRNIAGHN IHALKLESEL 200
    AALHKHEAAL VFSSCFVAND AVLSLFGQKI KDLVIFSDEL NHASMIQGIR 250
    NSRAKKQVFK HNDLADLEEK LAQYPKSTPK LIAFESVYSM CGSIAPIEAI 300
    CDLAEKYGAL TFLDEVHAVG MYGPHGAGVA EHLDFDAHLK SGIASPQTQT 350
    VMNRVDMVTG TLGKAYGTVG GYITGKANLI DWFRSFAPGF IFTTTLPPSI 400
    MAGSSASIRY QRSTLQDRIA QQTNTRYVKN NLTDIGIPVI PNPSHIVPVL 450
    VGNALDAKKA SDLLLDKYNI YVQAINFPTV PIGQERLRIT PTPGHGPELS 500
    NQLIGALDSV FNELSLSRIG DWEGKGGLCG VGEPDIEPIE HIWTSEQLAL 550
    TDADINPNVI DPVIQPIGVS SGVRD 575
    Length:575
    Mass (Da):62,652
    Last modified:August 16, 2004 - v1
    Checksum:i05107F73EB488A2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382134 Genomic DNA. Translation: CAG85193.1.
    RefSeqiXP_457198.1. XM_457198.1.

    Genome annotation databases

    GeneIDi2913002.
    KEGGidha:DEHA2B05478g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382134 Genomic DNA. Translation: CAG85193.1 .
    RefSeqi XP_457198.1. XM_457198.1.

    3D structure databases

    ProteinModelPortali Q6BX71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BX71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2913002.
    KEGGi dha:DEHA2B05478g.

    Phylogenomic databases

    eggNOGi COG0156.
    KOi K00643.
    OMAi KLAQYPK.
    OrthoDBi EOG7HHX1P.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiHEM1_DEBHA
    AccessioniPrimary (citable) accession number: Q6BX71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3