SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6BX71

- HEM1_DEBHA

UniProt

Q6BX71 - HEM1_DEBHA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
5-aminolevulinate synthase, mitochondrial
Gene
HEM1, DEHA2B05478g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241Substrate By similarity
Binding sitei237 – 2371Substrate By similarity
Binding sitei256 – 2561Substrate By similarity
Binding sitei289 – 2891Pyridoxal phosphate By similarity
Binding sitei317 – 3171Pyridoxal phosphate By similarity
Binding sitei361 – 3611Pyridoxal phosphate By similarity
Active sitei364 – 3641 By similarity
Binding sitei393 – 3931Pyridoxal phosphate By similarity
Binding sitei394 – 3941Pyridoxal phosphate By similarity
Binding sitei479 – 4791Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
Ordered Locus Names:DEHA2B05478g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome B

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5755-aminolevulinate synthase, mitochondrialPRO_0000001239
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei364 – 3641N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BX71.

Structurei

3D structure databases

ProteinModelPortaliQ6BX71.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
KOiK00643.
OMAiKLAQYPK.
OrthoDBiEOG7HHX1P.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BX71-1 [UniParc]FASTAAdd to Basket

« Hide

MESITRVSMS VCPFVKSSSA QALRQLSKNS ALTSQARQCP FMGAALNAKE    50
STRSYSSATK PVRATASSLA SNPPSTMQSK YSFKAEELVG NKDAINLESK 100
ENTFDFKGYL NSELSKKRTD KSYRFFNNIN RLANEFPKAH RSEENDKVTV 150
WCSNDYLGMG KNENTINEMK RVLTKYGSGA GGTRNIAGHN IHALKLESEL 200
AALHKHEAAL VFSSCFVAND AVLSLFGQKI KDLVIFSDEL NHASMIQGIR 250
NSRAKKQVFK HNDLADLEEK LAQYPKSTPK LIAFESVYSM CGSIAPIEAI 300
CDLAEKYGAL TFLDEVHAVG MYGPHGAGVA EHLDFDAHLK SGIASPQTQT 350
VMNRVDMVTG TLGKAYGTVG GYITGKANLI DWFRSFAPGF IFTTTLPPSI 400
MAGSSASIRY QRSTLQDRIA QQTNTRYVKN NLTDIGIPVI PNPSHIVPVL 450
VGNALDAKKA SDLLLDKYNI YVQAINFPTV PIGQERLRIT PTPGHGPELS 500
NQLIGALDSV FNELSLSRIG DWEGKGGLCG VGEPDIEPIE HIWTSEQLAL 550
TDADINPNVI DPVIQPIGVS SGVRD 575
Length:575
Mass (Da):62,652
Last modified:August 16, 2004 - v1
Checksum:i05107F73EB488A2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382134 Genomic DNA. Translation: CAG85193.1.
RefSeqiXP_457198.1. XM_457198.1.

Genome annotation databases

GeneIDi2913002.
KEGGidha:DEHA2B05478g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382134 Genomic DNA. Translation: CAG85193.1 .
RefSeqi XP_457198.1. XM_457198.1.

3D structure databases

ProteinModelPortali Q6BX71.
ModBasei Search...

Protein-protein interaction databases

STRINGi 4959.Q6BX71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2913002.
KEGGi dha:DEHA2B05478g.

Phylogenomic databases

eggNOGi COG0156.
KOi K00643.
OMAi KLAQYPK.
OrthoDBi EOG7HHX1P.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiHEM1_DEBHA
AccessioniPrimary (citable) accession number: Q6BX71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi