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Q6BX71

- HEM1_DEBHA

UniProt

Q6BX71 - HEM1_DEBHA

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Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241SubstrateBy similarity
Binding sitei237 – 2371SubstrateBy similarity
Binding sitei256 – 2561SubstrateBy similarity
Binding sitei289 – 2891Pyridoxal phosphateBy similarity
Binding sitei317 – 3171Pyridoxal phosphateBy similarity
Binding sitei361 – 3611Pyridoxal phosphateBy similarity
Active sitei364 – 3641By similarity
Binding sitei393 – 3931Pyridoxal phosphateBy similarity
Binding sitei394 – 3941Pyridoxal phosphateBy similarity
Binding sitei479 – 4791SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
Ordered Locus Names:DEHA2B05478g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome B

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5755-aminolevulinate synthase, mitochondrialPRO_0000001239
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei364 – 3641N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BX71.

Structurei

3D structure databases

ProteinModelPortaliQ6BX71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
InParanoidiQ6BX71.
KOiK00643.
OMAiKLAQYPK.
OrthoDBiEOG7HHX1P.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BX71-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESITRVSMS VCPFVKSSSA QALRQLSKNS ALTSQARQCP FMGAALNAKE
60 70 80 90 100
STRSYSSATK PVRATASSLA SNPPSTMQSK YSFKAEELVG NKDAINLESK
110 120 130 140 150
ENTFDFKGYL NSELSKKRTD KSYRFFNNIN RLANEFPKAH RSEENDKVTV
160 170 180 190 200
WCSNDYLGMG KNENTINEMK RVLTKYGSGA GGTRNIAGHN IHALKLESEL
210 220 230 240 250
AALHKHEAAL VFSSCFVAND AVLSLFGQKI KDLVIFSDEL NHASMIQGIR
260 270 280 290 300
NSRAKKQVFK HNDLADLEEK LAQYPKSTPK LIAFESVYSM CGSIAPIEAI
310 320 330 340 350
CDLAEKYGAL TFLDEVHAVG MYGPHGAGVA EHLDFDAHLK SGIASPQTQT
360 370 380 390 400
VMNRVDMVTG TLGKAYGTVG GYITGKANLI DWFRSFAPGF IFTTTLPPSI
410 420 430 440 450
MAGSSASIRY QRSTLQDRIA QQTNTRYVKN NLTDIGIPVI PNPSHIVPVL
460 470 480 490 500
VGNALDAKKA SDLLLDKYNI YVQAINFPTV PIGQERLRIT PTPGHGPELS
510 520 530 540 550
NQLIGALDSV FNELSLSRIG DWEGKGGLCG VGEPDIEPIE HIWTSEQLAL
560 570
TDADINPNVI DPVIQPIGVS SGVRD
Length:575
Mass (Da):62,652
Last modified:August 16, 2004 - v1
Checksum:i05107F73EB488A2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382134 Genomic DNA. Translation: CAG85193.1.
RefSeqiXP_457198.1. XM_457198.1.

Genome annotation databases

GeneIDi2913002.
KEGGidha:DEHA2B05478g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382134 Genomic DNA. Translation: CAG85193.1 .
RefSeqi XP_457198.1. XM_457198.1.

3D structure databases

ProteinModelPortali Q6BX71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BX71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2913002.
KEGGi dha:DEHA2B05478g.

Phylogenomic databases

eggNOGi COG0156.
InParanoidi Q6BX71.
KOi K00643.
OMAi KLAQYPK.
OrthoDBi EOG7HHX1P.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiHEM1_DEBHA
AccessioniPrimary (citable) accession number: Q6BX71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3