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Protein

Methionine aminopeptidase 2

Gene

MAP2

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172SubstrateUniRule annotation1
Metal bindingi192Divalent metal cation 1UniRule annotation1
Metal bindingi203Divalent metal cation 1UniRule annotation1
Metal bindingi203Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi272Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei280SubstrateUniRule annotation1
Metal bindingi305Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi400Divalent metal cation 1UniRule annotation1
Metal bindingi400Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandMetal-binding

Protein family/group databases

MEROPSiM24.002

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2UniRule annotation
Short name:
MetAP 2UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
Name:MAP2UniRule annotation
Ordered Locus Names:DEHA2C03894g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004076511 – 419Methionine aminopeptidase 2Add BLAST419

Proteomic databases

PRIDEiQ6BVB8

Structurei

3D structure databases

ProteinModelPortaliQ6BVB8
SMRiQ6BVB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 60Lys-richAdd BLAST13

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226278
InParanoidiQ6BVB8
KOiK01265
OMAiTINKHFG
OrthoDBiEOG092C3NQP

Family and domain databases

CDDicd01088 MetAP2, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03175 MetAP_2_euk, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002468 Pept_M24A_MAP2
IPR018349 Pept_M24A_MAP2_BS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55920 SSF55920, 2 hits
TIGRFAMsiTIGR00501 met_pdase_II, 1 hit
PROSITEiView protein in PROSITE
PS01202 MAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BVB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNSSNPNE VMEKVQDLKI DDSKPKVDSE EQPEAESDGE SATDGAQKKK
60 70 80 90 100
KKKKSKKKKK ITAIDNSYPD GVFPEGEWQE YPLDVNSYRT TSEEKRYLDR
110 120 130 140 150
QQNNHWQDFR KGAEIHRRVR HKAQSSIRPG MNMTEIADLI ENSVRSYANN
160 170 180 190 200
DHTLKAGIGF PTGLSLNHVA AHYTPNAGDK TVLNYEDVMK VDIGVHVNGH
210 220 230 240 250
IVDSAFTLTF DDKYDSLLKA VKEATNTGVK EAGIDVRLND IGEAIQEVME
260 270 280 290 300
SYEMELNGKT YPIKCIRNLN GHNIGDYLIH SGKTVPIVPN GDMTKMEEGE
310 320 330 340 350
TFAIETFGST GNGYVLPQGE CSHYAKNPGT DDIVVPGDKA KSLLNVINEN
360 370 380 390 400
FGTLPWCRRY LDRLGQDKYL LALNQLVRAG IVQDYPPIVD IKGSYTAQFE
410
HTILLHPHKK EVVSRGDDY
Length:419
Mass (Da):46,948
Last modified:November 4, 2008 - v2
Checksum:iFF3366D553F7D758
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382135 Genomic DNA Translation: CAG85896.2
RefSeqiXP_457851.2, XM_457851.1

Genome annotation databases

EnsemblFungiiCAG85896; CAG85896; DEHA2C03894g
GeneIDi2900504
KEGGidha:DEHA2C03894g

Entry informationi

Entry nameiMAP2_DEBHA
AccessioniPrimary (citable) accession number: Q6BVB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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