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Q6BVB2

- ALG11_DEBHA

UniProt

Q6BVB2 - ALG11_DEBHA

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.By similarity

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    Pathwayi

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Alpha-1,2-mannosyltransferase ALG11
    Asparagine-linked glycosylation protein 11
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:ALG11
    Ordered Locus Names:DEHA2C03982g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome C

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080275Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BVB2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BVB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase group 1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    HOGENOMiHOG000209670.
    KOiK03844.
    OMAiHPYANNG.
    OrthoDBiEOG7673KQ.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6BVB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYLVVIGVI ACVAYGILQV VSTVLPRLLL VPSQNWQDKI KKEIEQPMVR    50
    YLKVGNKRSS YRRRLVLASK QPSFYTNFVN NKIKVASVDS QNDEGEFLAE 100
    MKKRDVRDPQ RKIIYGFFHP YANNGGGGER VLWQAVQATL ATSDRNIVAI 150
    YTTNYESDPT SILDKVEAKF QISRLDEDRI VFVYLRKYAR LIDGDYWKRF 200
    TLIGQLFGSM VLSWEAMFEL SPDVWIDTIG LPGSYLLVSL VLKIPIMSYV 250
    HYPIIQPEMF NKLKFQGLSQ IRVPKLSEIK TDVFSIGKLI YWSGVFYFYK 300
    YLGSLVNITL ANGSWTFNHI SNIWTINKDE AGYEMDILYP PCGTETLTKN 350
    VETLGSRENK LLFIAQFRPE KRHSLILRQY SKFLVNATSI GTPLKNIPTL 400
    VFLGSCRTPD DTKTLHDLKQ EVDDLELNGY VEFVVDCSYE DIMVWLSKVK 450
    FGLNAMWNEH FGIGVVEYMS RGVIPLCHAS AGPLLDIVTN WDNEPTSVSW 500
    YNNTGFFFKD KSDPDFDLSL QSDTASEFLQ FSSRDNKDST STYPTLARLL 550
    DELFITNPDL ISETRLQSMR ENGVKSVLEK FSNGVFTLKW MQYSNQLGDL 600
    EKSYREERRS GIEKVY 616
    Length:616
    Mass (Da):70,746
    Last modified:December 16, 2008 - v2
    Checksum:i69F8BBC8881DF1DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382135 Genomic DNA. Translation: CAG85902.2.
    RefSeqiXP_457857.2. XM_457857.1.

    Genome annotation databases

    GeneIDi2900656.
    KEGGidha:DEHA2C03982g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382135 Genomic DNA. Translation: CAG85902.2 .
    RefSeqi XP_457857.2. XM_457857.1.

    3D structure databases

    ProteinModelPortali Q6BVB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BVB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2900656.
    KEGGi dha:DEHA2C03982g.

    Phylogenomic databases

    eggNOGi COG0438.
    HOGENOMi HOG000209670.
    KOi K03844.
    OMAi HPYANNG.
    OrthoDBi EOG7673KQ.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiALG11_DEBHA
    AccessioniPrimary (citable) accession number: Q6BVB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3