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Protein

ATP-dependent RNA helicase MAK5

Gene

MAK5

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2508ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase MAK5 (EC:3.6.4.13)
Gene namesi
Name:MAK5
Ordered Locus Names:DEHA2C05170g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome C

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790ATP-dependent RNA helicase MAK5PRO_0000232234Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6BV58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini230 – 427198Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini483 – 642160Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi199 – 22729Q motifAdd
BLAST
Motifi364 – 3674DEAD box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 151105Asp-richAdd
BLAST

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000290702.
InParanoidiQ6BV58.
KOiK14805.
OMAiIECGAME.
OrthoDBiEOG7NW6JS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BV58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSKDKSKK GVKSKPKTSR KPLSLKQKLQ RESKIVKVDN LNWKAVDIPD
60 70 80 90 100
NLDDYQGFYG LEEIDGVDVK VTGGNVEFVV KDNSKVKDSD NEEDDDDVHD
110 120 130 140 150
DDDNQDDGDD DQDDDDVDIE DDEDEIIEGD NEDDFKGFDD DNAINEDDQM
160 170 180 190 200
DIESAKTEKK SKKEVKPKNE KVAKKDSILE SAFKNVDLTL PDDNEVNLPY
210 220 230 240 250
WDDLSLSSFT LNGLSALEYE KPTAIQKRTI PLAIEGKDVI GKAITGSGKT
260 270 280 290 300
LAYGIPILER HLQKMAKANQ SKKVINPPTG IIFAPTRELA HQVVDHLNRI
310 320 330 340 350
AKFTPLSQHG IVSITGGLSI QKQERLLSHG PGIVVATPGR FLELLQKDMA
360 370 380 390 400
LVQRLSCTDI VVLDEADRLL QDGHFDEFVK ILELFGKHRP RDNKELEWKW
410 420 430 440 450
QTLVFSATFS RDLFGKLDKH LKSNKNKEEM GSSLIDNDEI LQLLNDKLKF
460 470 480 490 500
KDSKPTLVDA NPKEMVAGQI TEALVECGPT ERDLYLYYFL LLYPGSTLVF
510 520 530 540 550
ANSIDSVKRL APFLNNLKVP TFSIHSSMIQ KQRLRTLERF KEASSKNSTA
560 570 580 590 600
VLIASDVAAR GLDIPNIDHV AHYHLPRSAD VYIHRSGRTG RAGKEGVSIM
610 620 630 640 650
FCSPQESSGP LRKLRKLVAN NTKKRTRLNV HNDVKLLPLE MDLVSQIKPR
660 670 680 690 700
VTLASKLADA ERSSSSTRKE DNWVHEAAEE LGIDNLSDID NFEDDFIKRQ
710 720 730 740 750
RKRKENKALT KDEARSLRLE LNDLLSKQIR KNSRRSYLTS GLQNLAHQMV
760 770 780 790
TGNTHKDVLG HASVNALDDL RTKKAIKKKQ IKTKKVKDKK
Length:790
Mass (Da):89,112
Last modified:August 16, 2004 - v1
Checksum:iB69D00860CAE4879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382135 Genomic DNA. Translation: CAG85962.1.
RefSeqiXP_457911.1. XM_457911.1.

Genome annotation databases

EnsemblFungiiCAG85962; CAG85962; DEHA2C05170g.
GeneIDi2900812.
KEGGidha:DEHA2C05170g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382135 Genomic DNA. Translation: CAG85962.1.
RefSeqiXP_457911.1. XM_457911.1.

3D structure databases

ProteinModelPortaliQ6BV58.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG85962; CAG85962; DEHA2C05170g.
GeneIDi2900812.
KEGGidha:DEHA2C05170g.

Phylogenomic databases

HOGENOMiHOG000290702.
InParanoidiQ6BV58.
KOiK14805.
OMAiIECGAME.
OrthoDBiEOG7NW6JS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAK5_DEBHA
AccessioniPrimary (citable) accession number: Q6BV58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.