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Protein

ATP-dependent RNA helicase MAK5

Gene

MAK5

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi243 – 250ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase MAK5 (EC:3.6.4.13)
Gene namesi
Name:MAK5
Ordered Locus Names:DEHA2C05170g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002322341 – 790ATP-dependent RNA helicase MAK5Add BLAST790

Proteomic databases

PRIDEiQ6BV58

Structurei

3D structure databases

ProteinModelPortaliQ6BV58
SMRiQ6BV58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 427Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST198
Domaini483 – 642Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi199 – 227Q motifAdd BLAST29
Motifi364 – 367DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 151Asp-richAdd BLAST105

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000290702
InParanoidiQ6BV58
KOiK14805
OMAiYYFLLRY
OrthoDBiEOG092C1I7Y

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BV58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSKDKSKK GVKSKPKTSR KPLSLKQKLQ RESKIVKVDN LNWKAVDIPD
60 70 80 90 100
NLDDYQGFYG LEEIDGVDVK VTGGNVEFVV KDNSKVKDSD NEEDDDDVHD
110 120 130 140 150
DDDNQDDGDD DQDDDDVDIE DDEDEIIEGD NEDDFKGFDD DNAINEDDQM
160 170 180 190 200
DIESAKTEKK SKKEVKPKNE KVAKKDSILE SAFKNVDLTL PDDNEVNLPY
210 220 230 240 250
WDDLSLSSFT LNGLSALEYE KPTAIQKRTI PLAIEGKDVI GKAITGSGKT
260 270 280 290 300
LAYGIPILER HLQKMAKANQ SKKVINPPTG IIFAPTRELA HQVVDHLNRI
310 320 330 340 350
AKFTPLSQHG IVSITGGLSI QKQERLLSHG PGIVVATPGR FLELLQKDMA
360 370 380 390 400
LVQRLSCTDI VVLDEADRLL QDGHFDEFVK ILELFGKHRP RDNKELEWKW
410 420 430 440 450
QTLVFSATFS RDLFGKLDKH LKSNKNKEEM GSSLIDNDEI LQLLNDKLKF
460 470 480 490 500
KDSKPTLVDA NPKEMVAGQI TEALVECGPT ERDLYLYYFL LLYPGSTLVF
510 520 530 540 550
ANSIDSVKRL APFLNNLKVP TFSIHSSMIQ KQRLRTLERF KEASSKNSTA
560 570 580 590 600
VLIASDVAAR GLDIPNIDHV AHYHLPRSAD VYIHRSGRTG RAGKEGVSIM
610 620 630 640 650
FCSPQESSGP LRKLRKLVAN NTKKRTRLNV HNDVKLLPLE MDLVSQIKPR
660 670 680 690 700
VTLASKLADA ERSSSSTRKE DNWVHEAAEE LGIDNLSDID NFEDDFIKRQ
710 720 730 740 750
RKRKENKALT KDEARSLRLE LNDLLSKQIR KNSRRSYLTS GLQNLAHQMV
760 770 780 790
TGNTHKDVLG HASVNALDDL RTKKAIKKKQ IKTKKVKDKK
Length:790
Mass (Da):89,112
Last modified:August 16, 2004 - v1
Checksum:iB69D00860CAE4879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382135 Genomic DNA Translation: CAG85962.1
RefSeqiXP_457911.1, XM_457911.1

Genome annotation databases

EnsemblFungiiCAG85962; CAG85962; DEHA2C05170g
GeneIDi2900812
KEGGidha:DEHA2C05170g

Similar proteinsi

Entry informationi

Entry nameiMAK5_DEBHA
AccessioniPrimary (citable) accession number: Q6BV58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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