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Protein

Enoyl-[acyl-carrier-protein] reductase 2, mitochondrial

Gene

ETR2

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton donorBy similarity1
Binding sitei172NADPBy similarity1
Binding sitei382NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 202NADPBy similarity4
Nucleotide bindingi222 – 224NADPBy similarity3
Nucleotide bindingi297 – 300NADPBy similarity4
Nucleotide bindingi322 – 324NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase 2, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase 2
Gene namesi
Name:ETR2
Ordered Locus Names:DEHA2C05808g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome C

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionSequence analysisAdd BLAST23
ChainiPRO_000000090124 – 387Enoyl-[acyl-carrier-protein] reductase 2, mitochondrialAdd BLAST364

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BV30.
SMRiQ6BV30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683.
InParanoidiQ6BV30.
KOiK07512.
OMAiAFRGFWM.
OrthoDBiEOG092C2NJA.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BV30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRNQLARAS LRSTSSINQI RNMITAQAVV YAQHGEPKDV LKTLKYEIDD
60 70 80 90 100
DNLDSNSIIV KTLGSPVNPS DINQIQGVYP SKPEKTTELG SNEPVAVCGN
110 120 130 140 150
EGLFEILKVG DNVSNFKVGD WCVPTSVNMG TWRTHMLCGG DEMTKIPNPE
160 170 180 190 200
QSKANGKPSG LSVNQGATIS VNPLTAYLML THYVKLTPGK DWFIQNGGNS
210 220 230 240 250
AVGKYATQIS NLLGINSISV IRDRPDLQDL IKNMTEECGA TKVITEEQNA
260 270 280 290 300
SKEFGSEIKS WVKETGGEIK LALNCVGGKN STGIARKLNN NGLMLTYGGM
310 320 330 340 350
SMQPVILPTS LHIFKNITSS GFWVTQLLKN DVELKRKTLG QIIEWYENRQ
360 370 380
LKDAPSKETK FNPSDELSRY YIDGIVNSKG GKQLIVY
Length:387
Mass (Da):42,554
Last modified:August 16, 2004 - v1
Checksum:i800D3F11D4B64126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382135 Genomic DNA. Translation: CAG85995.1.
RefSeqiXP_457939.1. XM_457939.1.

Genome annotation databases

EnsemblFungiiCAG85995; CAG85995; DEHA2C05808g.
GeneIDi2900740.
KEGGidha:DEHA2C05808g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiETR2_DEBHA
AccessioniPrimary (citable) accession number: Q6BV30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: June 7, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families