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Q6BV30

- ETR2_DEBHA

UniProt

Q6BV30 - ETR2_DEBHA

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Protein
Probable trans-2-enoyl-CoA reductase 2, mitochondrial
Gene
ETR2, DEHA2C05808g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei172 – 1721NADP By similarity
Binding sitei382 – 3821NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2024NADP By similarity
Nucleotide bindingi222 – 2243NADP By similarity
Nucleotide bindingi297 – 3004NADP By similarity
Nucleotide bindingi322 – 3243NADP By similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase 2, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:ETR2
Ordered Locus Names:DEHA2C05808g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome C

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323Mitochondrion Reviewed prediction
Add
BLAST
Chaini24 – 387364Probable trans-2-enoyl-CoA reductase 2, mitochondrial
PRO_0000000901Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi4959.Q6BV30.

Structurei

3D structure databases

ProteinModelPortaliQ6BV30.
SMRiQ6BV30. Positions 23-387.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
KOiK07512.
OMAiCSTLWRV.
OrthoDBiEOG7PS1RH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6BV30-1 [UniParc]FASTAAdd to Basket

« Hide

MYRNQLARAS LRSTSSINQI RNMITAQAVV YAQHGEPKDV LKTLKYEIDD    50
DNLDSNSIIV KTLGSPVNPS DINQIQGVYP SKPEKTTELG SNEPVAVCGN 100
EGLFEILKVG DNVSNFKVGD WCVPTSVNMG TWRTHMLCGG DEMTKIPNPE 150
QSKANGKPSG LSVNQGATIS VNPLTAYLML THYVKLTPGK DWFIQNGGNS 200
AVGKYATQIS NLLGINSISV IRDRPDLQDL IKNMTEECGA TKVITEEQNA 250
SKEFGSEIKS WVKETGGEIK LALNCVGGKN STGIARKLNN NGLMLTYGGM 300
SMQPVILPTS LHIFKNITSS GFWVTQLLKN DVELKRKTLG QIIEWYENRQ 350
LKDAPSKETK FNPSDELSRY YIDGIVNSKG GKQLIVY 387
Length:387
Mass (Da):42,554
Last modified:August 16, 2004 - v1
Checksum:i800D3F11D4B64126
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382135 Genomic DNA. Translation: CAG85995.1.
RefSeqiXP_457939.1. XM_457939.1.

Genome annotation databases

GeneIDi2900740.
KEGGidha:DEHA2C05808g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382135 Genomic DNA. Translation: CAG85995.1 .
RefSeqi XP_457939.1. XM_457939.1.

3D structure databases

ProteinModelPortali Q6BV30.
SMRi Q6BV30. Positions 23-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BV30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2900740.
KEGGi dha:DEHA2C05808g.

Phylogenomic databases

eggNOGi COG0604.
HOGENOMi HOG000294683.
KOi K07512.
OMAi CSTLWRV.
OrthoDBi EOG7PS1RH.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiETR2_DEBHA
AccessioniPrimary (citable) accession number: Q6BV30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi