Reviewed, UniProtKB/Swiss-Prot Q6BV30 (ETR2_DEBHA)

Names and origin

Protein names

Recommended name:
    Probable trans-2-enoyl-CoA reductase 2, mitochondrial
    EC=1.3.1.38

Gene names

Name:	ETR2
Ordered Locus Names:	DEHA2C05808g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 23	23	Mitochondrion Potential
	Chain	24 – 387	364	Probable trans-2-enoyl-CoA reductase 2, mitochondrial		PRO_0000000901

Sequences

	Sequence		Length	Mass (Da)
	Q6BV30-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 800D3F11D4B64126	FASTA	387	42,554
	10 20 30 40 50 60 MYRNQLARAS LRSTSSINQI RNMITAQAVV YAQHGEPKDV LKTLKYEIDD DNLDSNSIIV 70 80 90 100 110 120 KTLGSPVNPS DINQIQGVYP SKPEKTTELG SNEPVAVCGN EGLFEILKVG DNVSNFKVGD 130 140 150 160 170 180 WCVPTSVNMG TWRTHMLCGG DEMTKIPNPE QSKANGKPSG LSVNQGATIS VNPLTAYLML 190 200 210 220 230 240 THYVKLTPGK DWFIQNGGNS AVGKYATQIS NLLGINSISV IRDRPDLQDL IKNMTEECGA 250 260 270 280 290 300 TKVITEEQNA SKEFGSEIKS WVKETGGEIK LALNCVGGKN STGIARKLNN NGLMLTYGGM 310 320 330 340 350 360 SMQPVILPTS LHIFKNITSS GFWVTQLLKN DVELKRKTLG QIIEWYENRQ LKDAPSKETK 370 380 FNPSDELSRY YIDGIVNSKG GKQLIVY

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382135 Genomic DNA. Translation: CAG85995.1.
RefSeq	XP_457939.1.
3D structure databases
SMR	Q6BV30. Positions 23-387.
ModBase	Search...
Genome annotation databases
GeneID	2900740.
KEGG	dha:DEHA0C06545g.
Phylogenomic databases
HOGENOM	Q6BV30.
OMA	Q6BV30. AYLMLTH.
Enzyme and pathway databases
BRENDA	1.3.1.38. 74267.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ETR2_DEBHA

Accession

Primary (citable) accession number: Q6BV30

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 16, 2004
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)