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Q6BV30 (ETR2_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable trans-2-enoyl-CoA reductase 2, mitochondrial

EC=1.3.1.38
Gene names
Name:ETR2
Ordered Locus Names:DEHA2C05808g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontrans-2-enoyl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2323Mitochondrion Potential
Chain24 – 387364Probable trans-2-enoyl-CoA reductase 2, mitochondrial
PRO_0000000901

Regions

Nucleotide binding199 – 2024NADP By similarity
Nucleotide binding222 – 2243NADP By similarity
Nucleotide binding297 – 3004NADP By similarity
Nucleotide binding322 – 3243NADP By similarity

Sites

Binding site1721NADP By similarity
Binding site3821NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BV30 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 800D3F11D4B64126

FASTA38742,554
        10         20         30         40         50         60 
MYRNQLARAS LRSTSSINQI RNMITAQAVV YAQHGEPKDV LKTLKYEIDD DNLDSNSIIV 

        70         80         90        100        110        120 
KTLGSPVNPS DINQIQGVYP SKPEKTTELG SNEPVAVCGN EGLFEILKVG DNVSNFKVGD 

       130        140        150        160        170        180 
WCVPTSVNMG TWRTHMLCGG DEMTKIPNPE QSKANGKPSG LSVNQGATIS VNPLTAYLML 

       190        200        210        220        230        240 
THYVKLTPGK DWFIQNGGNS AVGKYATQIS NLLGINSISV IRDRPDLQDL IKNMTEECGA 

       250        260        270        280        290        300 
TKVITEEQNA SKEFGSEIKS WVKETGGEIK LALNCVGGKN STGIARKLNN NGLMLTYGGM 

       310        320        330        340        350        360 
SMQPVILPTS LHIFKNITSS GFWVTQLLKN DVELKRKTLG QIIEWYENRQ LKDAPSKETK 

       370        380 
FNPSDELSRY YIDGIVNSKG GKQLIVY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382135 Genomic DNA. Translation: CAG85995.1.
RefSeqXP_457939.1. XM_457939.1.

3D structure databases

ProteinModelPortalQ6BV30.
SMRQ6BV30. Positions 23-387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BV30.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2900740.
KEGGdha:DEHA2C05808g.

Phylogenomic databases

eggNOGCOG0604.
HOGENOMHOG000294683.
KOK07512.
OMACSTLWRV.
OrthoDBEOG7PS1RH.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Entry information

Entry nameETR2_DEBHA
AccessionPrimary (citable) accession number: Q6BV30
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families