Reviewed, UniProtKB/Swiss-Prot Q6BV21 (KMO_DEBHA)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase
    Biosynthesis of nicotinic acid protein 4

Gene names

Name:	BNA4
Ordered Locus Names:	DEHA2C05984g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Mitochondrion
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Kynurenine 3-monooxygenase		PRO_0000361927

Sequences

	Sequence		Length	Mass (Da)
	Q6BV21-1 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: 1A7DC4AA9D9850ED	FASTA	473	53,966
	10 20 30 40 50 60 MASAKEDNKH QGVGIVGAGL VGCLTALAFA AKGFSVTLFE LRPDPKKVTN EKNLRSINLA 70 80 90 100 110 120 VSDRGIRTLK YVDSEMADRV LEHVIPMTGR MIHDLSGTKQ ESQAYGLFGE SINSIDRSFL 130 140 150 160 170 180 NDYLLDEIRH SDINVHFNHK LIRLDDLSSE EKSPKLTFLD TSESNESTMK SYEFDYVIGA 190 200 210 220 230 240 DGAHSQFRYQ LQKSMRMNIS QEYIDMQYLE LSIPPNTTGD SKFHIDPNHL HIWPRHEFML 250 260 270 280 290 300 IALANEDGSF TSTFFSPWSV IESFGTSSDK FIDFFKYNFP DAFKLMGEKK LRYAFENQPR 310 320 330 340 350 360 GSLMQVNAYP YHNPNGRALI IGDAAHSMVP FYGQGMNCGF EDIRVLMELI DKNNGEVSES 370 380 390 400 410 420 FRQYSVLRAE DLQTISKLAL DNYHEMSSKV TNVWYLFRKK IDNMLGRYGN GLFQWIPMYT 430 440 450 460 470 MISFRGDIPY SKAIKIEKRQ TKILNAIEVG TLTGFILFGA AKLAQHYHKL SNK

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382135 Genomic DNA. Translation: CAG86004.2.
RefSeq	XP_457948.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6BV21.
Genome annotation databases
GeneID	2899991.
GenomeReviews	Gene locus DEHA2C05984g in contig CR382135_GR.
KEGG	dha:DEHA0C06743g.
Phylogenomic databases
HOGENOM	Q6BV21.
OMA	LHAIMPS.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_DEBHA

Accession

Primary (citable) accession number: Q6BV21

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	November 4, 2008
Last modified:	November 3, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)