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Q6BV06

- BUR1_DEBHA

UniProt

Q6BV06 - BUR1_DEBHA

Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei68 – 681ATPPROSITE-ProRule annotation
    Active sitei174 – 1741Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 539ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:BUR1
    Ordered Locus Names:DEHA2C06358g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome C

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608Serine/threonine-protein kinase BUR1PRO_0000085681Add
    BLAST

    Proteomic databases

    PRIDEiQ6BV06.

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BV06.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BV06.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 346308Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK15562.
    OMAiRREGHIS.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6BV06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MECPEPSESV IPNDQSTKSC SIKLQPMNRF RDMSKLRNYE IIQKLGQGTF    50
    GVVQKARNIK TKELVALKQL INHSAKEGFP ITAMREITIL KKLNHKNILK 100
    IIDMIYEEPK ISNPQDILHQ RGCFYTVSPY MCSDLVGLLE NPNINLEVSH 150
    IKCFMEQLLH GIQYIHEQMF LHRDIKAANI LIDRNGTLKI ADFGLARVYH 200
    GSPPKFMSGP GGGERAYTGL VVTRWYRPPE LLLGERRYTT AVDMWGIGCV 250
    FGELFTRKPI LVGKTDSHQA QLIFDLVGPP NSISWSEATS LPNKHDLNIG 300
    LTCQRSLESK FAPLMNPDGI NLLSGLLTLD PYKRFNALDA LNHNYFKNEP 350
    LPMKPQELPK FEECHEIDKE RFKLLREKKN NIHEANKIPK AHFPKGPGEY 400
    NNSNNYPRNR NGSFPLALPK QPKFYNQHQQ EAHVPQQMHT DTYIPKKRDD 450
    KPGANAPQKE SSEPITSYQS LRDRSPRREG HISRKPSTTN SNNISSNSSA 500
    SNVGGTLSNP THQKNRPNAK ASAGIFMTNS RKQRPKPNPQ SSSRNVSDQF 550
    KKRKLLPDEQ NESDLTDFDE DVKDSKQLDS FLDWDTFTRS PENRKLQHEK 600
    KQFETKYS 608
    Length:608
    Mass (Da):69,467
    Last modified:August 16, 2004 - v1
    Checksum:iB27C11E4AAB8D95C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382135 Genomic DNA. Translation: CAG86021.1.
    RefSeqiXP_457963.1. XM_457963.1.

    Genome annotation databases

    GeneIDi2900800.
    KEGGidha:DEHA2C06358g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382135 Genomic DNA. Translation: CAG86021.1 .
    RefSeqi XP_457963.1. XM_457963.1.

    3D structure databases

    ProteinModelPortali Q6BV06.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BV06.

    Proteomic databases

    PRIDEi Q6BV06.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2900800.
    KEGGi dha:DEHA2C06358g.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K15562.
    OMAi RREGHIS.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiBUR1_DEBHA
    AccessioniPrimary (citable) accession number: Q6BV06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3