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Q6BV06 (BUR1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 608608Serine/threonine-protein kinase BUR1
PRO_0000085681

Regions

Domain39 – 346308Protein kinase
Nucleotide binding45 – 539ATP By similarity

Sites

Active site1741Proton acceptor By similarity
Binding site681ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BV06 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B27C11E4AAB8D95C

FASTA60869,467
        10         20         30         40         50         60 
MECPEPSESV IPNDQSTKSC SIKLQPMNRF RDMSKLRNYE IIQKLGQGTF GVVQKARNIK 

        70         80         90        100        110        120 
TKELVALKQL INHSAKEGFP ITAMREITIL KKLNHKNILK IIDMIYEEPK ISNPQDILHQ 

       130        140        150        160        170        180 
RGCFYTVSPY MCSDLVGLLE NPNINLEVSH IKCFMEQLLH GIQYIHEQMF LHRDIKAANI 

       190        200        210        220        230        240 
LIDRNGTLKI ADFGLARVYH GSPPKFMSGP GGGERAYTGL VVTRWYRPPE LLLGERRYTT 

       250        260        270        280        290        300 
AVDMWGIGCV FGELFTRKPI LVGKTDSHQA QLIFDLVGPP NSISWSEATS LPNKHDLNIG 

       310        320        330        340        350        360 
LTCQRSLESK FAPLMNPDGI NLLSGLLTLD PYKRFNALDA LNHNYFKNEP LPMKPQELPK 

       370        380        390        400        410        420 
FEECHEIDKE RFKLLREKKN NIHEANKIPK AHFPKGPGEY NNSNNYPRNR NGSFPLALPK 

       430        440        450        460        470        480 
QPKFYNQHQQ EAHVPQQMHT DTYIPKKRDD KPGANAPQKE SSEPITSYQS LRDRSPRREG 

       490        500        510        520        530        540 
HISRKPSTTN SNNISSNSSA SNVGGTLSNP THQKNRPNAK ASAGIFMTNS RKQRPKPNPQ 

       550        560        570        580        590        600 
SSSRNVSDQF KKRKLLPDEQ NESDLTDFDE DVKDSKQLDS FLDWDTFTRS PENRKLQHEK 


KQFETKYS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382135 Genomic DNA. Translation: CAG86021.1.
RefSeqXP_457963.1. XM_457963.1.

3D structure databases

ProteinModelPortalQ6BV06.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BV06.

Proteomic databases

PRIDEQ6BV06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2900800.
KEGGdha:DEHA2C06358g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK15562.
OMARREGHIS.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_DEBHA
AccessionPrimary (citable) accession number: Q6BV06
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families