Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681ATPPROSITE-ProRule annotation
Active sitei174 – 1741Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 539ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:BUR1
Ordered Locus Names:DEHA2C06358g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599 Componenti: Chromosome C

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Serine/threonine-protein kinase BUR1PRO_0000085681Add
BLAST

Proteomic databases

PRIDEiQ6BV06.

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BV06.

Structurei

3D structure databases

ProteinModelPortaliQ6BV06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 346308Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6BV06.
KOiK15562.
OMAiRREGHIS.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BV06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECPEPSESV IPNDQSTKSC SIKLQPMNRF RDMSKLRNYE IIQKLGQGTF
60 70 80 90 100
GVVQKARNIK TKELVALKQL INHSAKEGFP ITAMREITIL KKLNHKNILK
110 120 130 140 150
IIDMIYEEPK ISNPQDILHQ RGCFYTVSPY MCSDLVGLLE NPNINLEVSH
160 170 180 190 200
IKCFMEQLLH GIQYIHEQMF LHRDIKAANI LIDRNGTLKI ADFGLARVYH
210 220 230 240 250
GSPPKFMSGP GGGERAYTGL VVTRWYRPPE LLLGERRYTT AVDMWGIGCV
260 270 280 290 300
FGELFTRKPI LVGKTDSHQA QLIFDLVGPP NSISWSEATS LPNKHDLNIG
310 320 330 340 350
LTCQRSLESK FAPLMNPDGI NLLSGLLTLD PYKRFNALDA LNHNYFKNEP
360 370 380 390 400
LPMKPQELPK FEECHEIDKE RFKLLREKKN NIHEANKIPK AHFPKGPGEY
410 420 430 440 450
NNSNNYPRNR NGSFPLALPK QPKFYNQHQQ EAHVPQQMHT DTYIPKKRDD
460 470 480 490 500
KPGANAPQKE SSEPITSYQS LRDRSPRREG HISRKPSTTN SNNISSNSSA
510 520 530 540 550
SNVGGTLSNP THQKNRPNAK ASAGIFMTNS RKQRPKPNPQ SSSRNVSDQF
560 570 580 590 600
KKRKLLPDEQ NESDLTDFDE DVKDSKQLDS FLDWDTFTRS PENRKLQHEK

KQFETKYS
Length:608
Mass (Da):69,467
Last modified:August 16, 2004 - v1
Checksum:iB27C11E4AAB8D95C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382135 Genomic DNA. Translation: CAG86021.1.
RefSeqiXP_457963.1. XM_457963.1.

Genome annotation databases

GeneIDi2900800.
KEGGidha:DEHA2C06358g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382135 Genomic DNA. Translation: CAG86021.1.
RefSeqiXP_457963.1. XM_457963.1.

3D structure databases

ProteinModelPortaliQ6BV06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4959.Q6BV06.

Proteomic databases

PRIDEiQ6BV06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2900800.
KEGGidha:DEHA2C06358g.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6BV06.
KOiK15562.
OMAiRREGHIS.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUR1_DEBHA
AccessioniPrimary (citable) accession number: Q6BV06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.