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Q6BUV9

- HIS4_DEBHA

UniProt

Q6BUV9 - HIS4_DEBHA

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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene
HIS6, DEHA2C07568g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:HIS6
Ordered Locus Names:DEHA2C07568g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome C

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2762761-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000141958Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4959.Q6BUV9.

Structurei

3D structure databases

ProteinModelPortaliQ6BUV9.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000172261.
KOiK01814.
OMAiFVAMNKW.
OrthoDBiEOG7ZWDC9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR21169. PTHR21169. 1 hit.
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6BUV9-1 [UniParc]FASTAAdd to Basket

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MTKFRGCIDI HSGQVKQIVG GTLTQDDTTE LNHKSTTTEN FVSTKPSSYY    50
AELYKNAGIN GCHVIKLGSN PENDEAAKLA CQSWPNNLQV GGGINGDNAL 100
EWLDVHKASH VILTSWLFSD SDEGKEFDWV KLKRVSELVG KSRLIVDLSC 150
RELRVDDKIE WVVAMNKWQT LTNNKLSAEF LGEVSQYCDE FLIHAADVEG 200
LCNGIDVNLV AKLGEWCPEG FEGKIVYAGG ARSVKDLDTV SKLSDDKVDL 250
TYGSALDVFG GKLVKFDDLV SWNELH 276
Length:276
Mass (Da):30,521
Last modified:December 16, 2008 - v2
Checksum:i1D02F6F017793872
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382135 Genomic DNA. Translation: CAG86070.2.
RefSeqiXP_458010.2. XM_458010.1.

Genome annotation databases

GeneIDi2900784.
KEGGidha:DEHA2C07568g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382135 Genomic DNA. Translation: CAG86070.2 .
RefSeqi XP_458010.2. XM_458010.1.

3D structure databases

ProteinModelPortali Q6BUV9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BUV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2900784.
KEGGi dha:DEHA2C07568g.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000172261.
KOi K01814.
OMAi FVAMNKW.
OrthoDBi EOG7ZWDC9.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
PANTHERi PTHR21169. PTHR21169. 1 hit.
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02129. hisA_euk. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiHIS4_DEBHA
AccessioniPrimary (citable) accession number: Q6BUV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: December 16, 2008
Last modified: November 13, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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