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Q6BUV9

- HIS4_DEBHA

UniProt

Q6BUV9 - HIS4_DEBHA

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

HIS6

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
    Alternative name(s):
    5-proFAR isomerase
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
    Gene namesi
    Name:HIS6
    Ordered Locus Names:DEHA2C07568g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome C

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2762761-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000141958Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4959.Q6BUV9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BUV9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.Curated

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000172261.
    KOiK01814.
    OMAiFVAMNKW.
    OrthoDBiEOG7ZWDC9.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PANTHERiPTHR21169. PTHR21169. 1 hit.
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6BUV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKFRGCIDI HSGQVKQIVG GTLTQDDTTE LNHKSTTTEN FVSTKPSSYY    50
    AELYKNAGIN GCHVIKLGSN PENDEAAKLA CQSWPNNLQV GGGINGDNAL 100
    EWLDVHKASH VILTSWLFSD SDEGKEFDWV KLKRVSELVG KSRLIVDLSC 150
    RELRVDDKIE WVVAMNKWQT LTNNKLSAEF LGEVSQYCDE FLIHAADVEG 200
    LCNGIDVNLV AKLGEWCPEG FEGKIVYAGG ARSVKDLDTV SKLSDDKVDL 250
    TYGSALDVFG GKLVKFDDLV SWNELH 276
    Length:276
    Mass (Da):30,521
    Last modified:December 16, 2008 - v2
    Checksum:i1D02F6F017793872
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382135 Genomic DNA. Translation: CAG86070.2.
    RefSeqiXP_458010.2. XM_458010.1.

    Genome annotation databases

    GeneIDi2900784.
    KEGGidha:DEHA2C07568g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382135 Genomic DNA. Translation: CAG86070.2 .
    RefSeqi XP_458010.2. XM_458010.1.

    3D structure databases

    ProteinModelPortali Q6BUV9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BUV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2900784.
    KEGGi dha:DEHA2C07568g.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000172261.
    KOi K01814.
    OMAi FVAMNKW.
    OrthoDBi EOG7ZWDC9.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    PANTHERi PTHR21169. PTHR21169. 1 hit.
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02129. hisA_euk. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiHIS4_DEBHA
    AccessioniPrimary (citable) accession number: Q6BUV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3