Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6BUV9 (HIS4_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

EC=5.3.1.16
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene names
Name:HIS6
Ordered Locus Names:DEHA2C07568g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the HisA/HisF family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2762761-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
PRO_0000141958

Sequences

Sequence LengthMass (Da)Tools
Q6BUV9 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 1D02F6F017793872

FASTA27630,521
        10         20         30         40         50         60 
MTKFRGCIDI HSGQVKQIVG GTLTQDDTTE LNHKSTTTEN FVSTKPSSYY AELYKNAGIN 

        70         80         90        100        110        120 
GCHVIKLGSN PENDEAAKLA CQSWPNNLQV GGGINGDNAL EWLDVHKASH VILTSWLFSD 

       130        140        150        160        170        180 
SDEGKEFDWV KLKRVSELVG KSRLIVDLSC RELRVDDKIE WVVAMNKWQT LTNNKLSAEF 

       190        200        210        220        230        240 
LGEVSQYCDE FLIHAADVEG LCNGIDVNLV AKLGEWCPEG FEGKIVYAGG ARSVKDLDTV 

       250        260        270 
SKLSDDKVDL TYGSALDVFG GKLVKFDDLV SWNELH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382135 Genomic DNA. Translation: CAG86070.2.
RefSeqXP_458010.2. XM_458010.1.

3D structure databases

ProteinModelPortalQ6BUV9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BUV9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2900784.
KEGGdha:DEHA2C07568g.

Phylogenomic databases

eggNOGCOG0106.
HOGENOMHOG000172261.
KOK01814.
OMAFVAMNKW.
OrthoDBEOG7ZWDC9.

Enzyme and pathway databases

UniPathwayUPA00031; UER00009.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERPTHR21169. PTHR21169. 1 hit.
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02129. hisA_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS4_DEBHA
AccessionPrimary (citable) accession number: Q6BUV9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: December 16, 2008
Last modified: November 13, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways