Q6BTV5 (SIL1_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleotide exchange factor SIL1

Gene names

Name:	SIL1
Ordered Locus Names:	DEHA2C15664g

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

284592 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces › Debaryomyces hansenii › Debaryomyces hansenii var. hansenii

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.
Subunit structure	Interacts with KAR2 By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the SIL1 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Endoplasmic reticulum
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 427	405	Nucleotide exchange factor SIL1		PRO_0000223362
Regions
	Motif	424 – 427	4	Prevents secretion from ER Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6BTV5 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: ACCDA7231D0A3B3B	FASTA	427	47,943
	10 20 30 40 50 60 MKLSKGVLSS ILLTLLIKPI ESSIVNTDGE LICAPNNPTD CYPKIFEPTT EWQTIREGQD 70 80 90 100 110 120 IPAGLHVRLN MENLAREAKI LDPSEETEGS SELMVNAEQN NDNGDNSHQM TNEDQANEIQ 130 140 150 160 170 180 QKIKEFKQTQ GKSKVSTVDL NDFQSSVDEV QHYREGGDAN RLSTALDTLI DLSHDIEFGV 190 200 210 220 230 240 KLTQDSSVFR SLVDVSKSVQ DEDLQEKVYR IMGSSLRNNP DAVNHVLKNQ DATFVECLFD 250 260 270 280 290 300 KLDTDASDVI KKRILGIIHA LTQNSHFNAK YFNSNNANSA VDSLISVFPS LESQSQTRLM 310 320 330 340 350 360 NILEDLKLLG GANSNEKRAI EESADPKSQY SHFLQHSLAD SGVASEDQFK LYFNKLSEVH 370 380 390 400 410 420 SQDKSLKPSK AFMEWLSKEA ELRSKGNKER DSSYTEEDRQ FDQDLLRARH VVFGNPMGLR KALADEL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382135 Genomic DNA. Translation: CAR65586.1.
RefSeq	XP_002770223.1. XM_002770177.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8998396.
KEGG	dha:DEHA2C15664g.
Phylogenomic databases
eggNOG	NOG284817.
HOGENOM	HOG000094513.
KO	K14001.
OMA	SHDIEFG.
OrthoDB	EOG40312K.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIL1_DEBHA

Accession

Primary (citable) accession number: Q6BTV5
Secondary accession number(s): B5RTC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program