Q6BT11 (BNA7_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable kynurenine formamidase
EC=3.5.1.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 7
Probable N-formylkynurenine formamidase

Gene names

Name:	BNA7
Ordered Locus Names:	DEHA2D04422g

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

284592 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H) By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the BNA7 family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arylformamidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Probable kynurenine formamidase		PRO_0000361882
Sites
	Active site	33	1	Potential
	Active site	107	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6BT11 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: 2F51151537260898	FASTA	291	33,536
	10 20 30 40 50 60 MDDGIVSYGE HPLNRLKFFQ FDKSNDVTLL LIHGGAWRDP NNTYNDFKDM ISHIQKNQYA 70 80 90 100 110 120 AKYNLIAMNY RLSPEVKHPF HLWDVLEGLQ FLVQNYDIHK ISIAGHSVGA TLMLQLLDYN 130 140 150 160 170 180 KILDTGFQIL VEDSKADKNR TETDLHVPSK KERILMNEAM EKLQLRTFCF IDGIYDITQL 190 200 210 220 230 240 ISEYGCPYES FVNNAFSSPE QYAEATQLSS STVDVGSPFS YNTHSANVRN ELNLVILQSN 250 260 270 280 290 KDELLSMRQT NLFIEYLTQK NLNFKPFVGE WGGHEHVYRH EDVANIVLDS I

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382136 Genomic DNA. Translation: CAG86798.2.
RefSeq	XP_458659.2. XM_458659.1.
3D structure databases
ProteinModelPortal	Q6BT11.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2901179.
GenomeReviews	Gene locus DEHA2D04422g in contig CR382136_GR.
KEGG	dha:DEHA2D04422g.
Phylogenomic databases
eggNOG	fuNOG11665.
HOGENOM	HBG395624.
OMA	NTHSANV.
OrthoDB	EOG4GMZ6M.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. [Graphical view]
KO	K14263.
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BNA7_DEBHA

Accession

Primary (citable) accession number: Q6BT11

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	November 4, 2008
Last modified:	November 16, 2011
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program