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Q6BSU4 (Q6BSU4_DEBHA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:DEHA2D06160g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 176NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding35 – 373NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding77 – 793NADP By similarity PIRSR PIRSR000109-3
Region131 – 1333Substrate binding By similarity PIRSR PIRSR000109-2
Region188 – 1892Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1851Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1921Proton donor By similarity PIRSR PIRSR000109-1
Binding site1051NADP By similarity PIRSR PIRSR000109-3
Binding site1051Substrate By similarity PIRSR PIRSR000109-2
Binding site1931Substrate By similarity PIRSR PIRSR000109-2
Binding site2631Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2901Substrate By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4581Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q6BSU4 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: EBF07EB935A528EE

FASTA49554,316
        10         20         30         40         50         60 
MSAPTGDIGL IGLAVMGQNL ILNAADNGYT VVAYNRTVAK VDDFLDNEAK GKSVIGAHSI 

        70         80         90        100        110        120 
EELCANLKRP RRIILLVKAG KPVDAFIEQL LPHLEKGDII IDGGNSHFPD SNRRYEELNG 

       130        140        150        160        170        180 
KGILFVGSGV SGGEEGARYG PSLMPGGHKD AWPHIKDIFQ SIAAKSDGEP CCDWVGDAGA 

       190        200        210        220        230        240 
GHYVKMVHNG IEYGDMQLIC EAYDLLKRVG KFSNKEIGDV FAKWNKGVLD SFLIEITRDI 

       250        260        270        280        290        300 
LYFNDPTDNK PLLEKILDTA GQKGTGKWTA INALDLGMPV TLIGEAVFSR CLSALKDERV 

       310        320        330        340        350        360 
RASKSLAGPS VEDDESPIQD KQKFVDDLEQ ALYASKIISY AQGFMLIREA AKEYGWKLNN 

       370        380        390        400        410        420 
PAIALMWRGG CIIRSVFLGE ITSAYRETPD LENLLFHPFF NDAIKKAQKG WRSTIGKAVE 

       430        440        450        460        470        480 
FGVPVPAFST ALSFYDGYRS AKLPANLLQA QRDYFGAHTF QVLPGEENDF LKKDQWIHVN 

       490 
WTGKGGNVSA STYDA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382136 Genomic DNA. Translation: CAG86870.1.
RefSeqXP_458726.1. XM_458726.1.

3D structure databases

ProteinModelPortalQ6BSU4.
SMRQ6BSU4. Positions 5-482.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6BSU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2901245.
GenomeReviewsGene locus DEHA2D06160g in contig CR382136_GR.
KEGGdha:DEHA2D06160g.

Phylogenomic databases

eggNOGfuNOG05795.
HOGENOMHBG286913.
OMASNRRTKY.
OrthoDBEOG4VDT6Z.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6BSU4_DEBHA
AccessionPrimary (citable) accession number: Q6BSU4
Entry history
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info