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Q6BSQ1

- HAT1_DEBHA

UniProt

Q6BSQ1 - HAT1_DEBHA

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Protein

Histone acetyltransferase type B catalytic subunit

Gene
HAT1, DEHA2D07062g
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
Gene namesi
Name:HAT1
Ordered Locus Names:DEHA2D07062g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Chromosome D

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. histone acetyltransferase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Histone acetyltransferase type B catalytic subunitPRO_0000227723Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.

Protein-protein interaction databases

STRINGi4959.Q6BSQ1.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAT1 family.

Phylogenomic databases

eggNOGiNOG326277.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6BSQ1-1 [UniParc]FASTAAdd to Basket

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MSDNSPITSI TAASLQPELW TSSSNDALQI YITDSDGTAL NFHPNFTYPI    50
FGDSEQIFGY RDLVIFLCFD HCTFYPFLNV KYSDKLNDDT LEDPREKLLS 100
YLPESTIFKD EVKWVDSINK EKEGFEIPGE LVGNIFTHGD DKFGIYKLDL 150
KNAQGLELHK RLQILVLLFI EAGSYIDHQD ELWDIYVMYK VTDEKTPSII 200
GFCTAYNYWK YGGFEKFDSN QQEVRKKISQ FIVLPMYQGL KLGGRFYNKL 250
YEYWMQDPRV IEVVVEDPSE SFDDLRDRCD LTRLCQNTIK VASVDLPLIN 300
TEWATKLRQE QKLEKRQFSR LLEMILIYQL EHNLTNITKK QVRLFIKKRL 350
YEKNKEILDG LDEPTRLDKL QTAYASLESD YKRILSGLSL HKRALDSTEG 400
SSKKSKPNV 409
Length:409
Mass (Da):47,711
Last modified:December 16, 2008 - v2
Checksum:i2A9794B7363E08C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382136 Genomic DNA. Translation: CAG86913.2.
RefSeqiXP_458769.2. XM_458769.1.

Genome annotation databases

GeneIDi2901027.
KEGGidha:DEHA2D07062g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382136 Genomic DNA. Translation: CAG86913.2 .
RefSeqi XP_458769.2. XM_458769.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4959.Q6BSQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2901027.
KEGGi dha:DEHA2D07062g.

Phylogenomic databases

eggNOGi NOG326277.
KOi K11303.
OMAi HISYDEK.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiHAT1_DEBHA
AccessioniPrimary (citable) accession number: Q6BSQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 16, 2008
Last modified: November 13, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi