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Q6BS75 (KPYK_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate kinase
Short name=PK
EC=2.7.1.40
Gene names
Name:PYK1
Ordered Locus Names:DEHA2D11044g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces ›

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Pyruvate kinase
PRO_0000112112

Sites

Metal binding551Potassium By similarity
Metal binding571Potassium By similarity
Metal binding881Potassium By similarity
Metal binding891Potassium; via carbonyl oxygen By similarity
Metal binding2461Magnesium Potential
Metal binding2701Magnesium By similarity
Binding site531Substrate By similarity
Binding site2691Substrate; via amide nitrogen By similarity
Binding site2701Substrate; via amide nitrogen By similarity
Binding site3021Substrate By similarity
Binding site3411ADP Potential
Site2441Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BS75 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: BE5F4E1B571C5595

FASTA50455,714
        10         20         30         40         50         60 
MSNASLSWLT KLNTSETPDK VLRRSSIIGT IGPKTNNVDV LVKLRKAGLN IVRMNFSHGS 

        70         80         90        100        110        120 
YEYHQSVIDN AKQSEEIYKG RPLAIALDTK GPEIRTGTTI DDKDYPILPN HEMIFTTDEA 

       130        140        150        160        170        180 
YAKKCDDKVM FIDYKNITKV IEAGKIIYID DGVVSFEVLQ IVDDKTLKVR SVNSGKICSH 

       190        200        210        220        230        240 
KGVNLPGTDV DLPALSEKDK ADIKFGVKNG VHMIFASFIR TGDDIKEIRK VLGEEGKDIQ 

       250        260        270        280        290        300 
IIAKIENQQG VNNFDEILVE TDGVMVARGD LGIEIPAPQV FVVQKQLIAK CNLAAKPVIC 

       310        320        330        340        350        360 
ATQMLESMTY NPRPTRAEVS DVGNAILDGA DCVMLSGETA KGNYPFEAVS MMHNTAIIAE 

       370        380        390        400        410        420 
KAIAYQPLHN EIRSLANRPT PTTETCAMAS VSAAYEQDAK AIVVLSTSGF TSRLVSKYKP 

       430        440        450        460        470        480 
NVPVMMVTRN HRAARYCHLY RGVYPFVYEK KTVDNWQEDV ENRLRWAVSE AIDLGIIKKG 

       490        500 
DSIVTIQGWT RGSGHSNTVR VVQA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382136 Genomic DNA. Translation: CAG87106.1.
RefSeqXP_458945.1. XM_458945.1.

3D structure databases

ProteinModelPortalQ6BS75.
SMRQ6BS75. Positions 22-501.
ModBaseSearch...

Protein-protein interaction databases

STRING4959.Q6BS75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2901740.
KEGGdha:DEHA2D11044g.

Phylogenomic databases

eggNOGCOG0469.
KOK00873.
OMAVKMMATI.
OrthoDBEOG43XZC1.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. PK_B_barrel_like. 1 hit.
SSF52935. Pyruvate_kinase. 1 hit.
SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_DEBHA
AccessionPrimary (citable) accession number: Q6BS75
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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