Reviewed, UniProtKB/Swiss-Prot Q6BS08 (ATG1_DEBHA)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
Ordered Locus Names:	DEHA2D12452g

Organism

Debaryomyces hansenii (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

4959 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Debaryomyces

Protein attributes

Sequence length	875 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 875	875	Serine/threonine-protein kinase ATG1		PRO_0000085645
Regions
	Domain	22 – 318	297	Protein kinase
	Nucleotide binding	28 – 36	9	ATP By similarity
Sites
	Active site	168	1	Proton acceptor By similarity
	Binding site	51	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6BS08-1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 0044280B7D50B9A2	FASTA	875	97,889
	10 20 30 40 50 60 MSTTSIESNN DIGRSVKTIG VYSIGPEIGK GSFATVYKCF NTKTNESVAI KSVVRSKLKS 70 80 90 100 110 120 KKLVENLEIE ISILKTMKHP HIVGLLDYKQ TTSHFHLVMD YCSMGDLSYF IRKRNQLIKT 130 140 150 160 170 180 HPVISSLLER YPSPEGSHGL NEVLVIHFLK QLVSALEFLR NKSLVHRDIK PQNLLLCPPL 190 200 210 220 230 240 HSKQEFKDGG FVGLWELPLL KIADFGFARF LPSTSMAETL CGSPLYMAPE ILRYEKYNAK 250 260 270 280 290 300 ADLWSVGAVL YEMTVGKPPF RADNHVQLLK NIEKSNDRIK FPSAAQVPES LKRLIRSLLK 310 320 330 340 350 360 YNPTERVSFN EFFNDPLIVN DLEGNDEPLE TSEMDENLFI SEYISPIKSS QKSQYIEPIT 370 380 390 400 410 420 TEVAVKEKSK QDLPAREVST HASESQTKAV DTRPSSRDEE IKEIINKNSP GPETSRSIQP 430 440 450 460 470 480 HNLKEKSLVL KNKDNDIILE RDYVVVEKRA VEVNAIADEL AHAGSGAVAI NPRRTSSGSD 490 500 510 520 530 540 NSYNGPNNMQ LYRRPSLRSN SSGSQRRPSF TDRRISISIS PTNALTKAIG LASNRLFGVN 550 560 570 580 590 600 ASGSPTNRLI EETDERLAIN ENNSSMNATN NTFSTILSNP NFANNLLIQK LNLPTSATVA 610 620 630 640 650 660 NNSQTNTSPQ LSPQSKTDES VLNRLESLAT KAHAINLFAD VKFSQLIPSP PSSDALDDDL 670 680 690 700 710 720 LHQNDMLPPK IVKSISEEGV VLYVKTLSLL AKGMVIASDW WYSQFEIDDP SNKNSNENPL 730 740 750 760 770 780 KQSSNNNSDD LSLAVRINEL VQWIREKFNE CLEKAEFIRL TLQEANTLLS NEDSSEYMGN 790 800 810 820 830 840 SNSVADKTRV VAEKLIFDRA LEMSRNAAVN ELVKEDLKGC ELAYSTAIWM LEALLDEDSS 850 860 870 NDEDRLDDED KAMVEKFIVS IGNRLSVLKR KLEVV

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / IFO 0083 / IGC 2968 / JCM 1990.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382136 Genomic DNA. Translation: CAG87180.2.
RefSeq	XP_459012.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2900978.
KEGG	dha:DEHA0D13684g.
Phylogenomic databases
HOGENOM	Q6BS08.
OMA	Q6BS08. KYNAKAD.
Enzyme and pathway databases
BRENDA	2.7.11.1. 74267.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_DEBHA

Accession

Primary (citable) accession number: Q6BS08

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	December 16, 2008
Last modified:	June 16, 2009
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)