Q6BS00 (ACS2_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase 2
Acyl-activating enzyme 2

Gene names

Name:	ACS2
Ordered Locus Names:	DEHA2D12606g

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]

Taxonomic identifier

284592 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces

Protein attributes

Sequence length	679 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 679	679	Acetyl-coenzyme A synthetase 2		PRO_0000208412

Sequences

	Sequence		Length	Mass (Da)
	Q6BS00 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: AD17F7989E476776	FASTA	679	74,992
	10 20 30 40 50 60 MTSSPTHQVV HEANNIKKQE TPKEFFERQP RQGHITSLEQ YQELYEKSIN DPETFFGEFG 70 80 90 100 110 120 KELLHWDRDF ERVKSGSLLH GDAAWFIGGQ LNACYNCVDR HAFATPNKPA IIYEADEEKD 130 140 150 160 170 180 SKILTFAELL REVCQVAGVL QSWGIKKGDT VAIYMPMNSQ AIIAMLAVAR LGAIHSVIFA 190 200 210 220 230 240 GFSSGSIKDR VNDASCKALI TCDEGRRGGK TINIKKLCDE ALLNCPSIEK VLVYERTGNK 250 260 270 280 290 300 EVTLKEGRDY WWSEETQKFA GYLPPVPVNS EDPLFLLYTS GSTGTPKGVV HSTAGYLLGA 310 320 330 340 350 360 ALTTKYVFDI HPEDVLFTAG DVGWITGHTY ALYGPLSLGV PTVVFEGTPA FPDYGRLWQI 370 380 390 400 410 420 VEKHKATHFY VAPTALRLLR KSGEQEIEKY DLSSLRTLGS VGEPISPDIW EWYNEKVGKG 430 440 450 460 470 480 QCHVTDTYWQ TESGSHFIAP IAGVVPNKPG SAAVPFFGIQ TCLIDPVSGI EIQGNDVEGV 490 500 510 520 530 540 LAVKDTWPSM ARSVYKNHTK YMDTYLNPYP GYYFTGDGAA RDHDGYYWIR GRVDDVVNVS 550 560 570 580 590 600 GHRLSTAEIE AALIEHNAIS EAAVVGMNDD LTGQTVVAFV ALKEHLIANL KADESPEEAL 610 620 630 640 650 660 KLKKEMILQV RTQIGPFAAP KSVIIVEDLP KTRSGKIMRR ILRKIAAGEA DQLGDITTLS 670 NPQSVAGIIG SFDSQFGKK

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382136 Genomic DNA. Translation: CAG87188.1.
RefSeq	XP_459020.1. XM_459020.1.
3D structure databases
ProteinModelPortal	Q6BS00.
SMR	Q6BS00. Positions 39-647.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6BS00.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2901554.
GenomeReviews	Gene locus DEHA2D12606g in contig CR382136_GR.
KEGG	dha:DEHA2D12606g.
Phylogenomic databases
eggNOG	fuNOG05220.
HOGENOM	HBG547964.
OMA	QCHISDT.
OrthoDB	EOG4M0J8W.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS2_DEBHA

Accession

Primary (citable) accession number: Q6BS00

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program