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Q6BRY4

- ACEA_DEBHA

UniProt

Q6BRY4 - ACEA_DEBHA

Protein

Isocitrate lyase

Gene

ICL1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei210 – 2101PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:ICL1
    Ordered Locus Names:DEHA2D12936g
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Chromosome D

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Isocitrate lyasePRO_0000068789Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi4959.Q6BRY4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6BRY4.
    SMRiQ6BRY4. Positions 8-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2224.
    KOiK01637.
    OMAiALISHQF.
    OrthoDBiEOG73Z331.

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6BRY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYTKIDVNE EEKFFQDQVK EIQQWWKEPR WAKTKRIYQA EDIAKKRSSL    50
    KVDYPSSNQA KKLYKLLQEH DKNKSASFTF GALDPVQVTQ MAKYLDSIYV 100
    SGWQCSSTAS TSNEPSPDLA DYPMDTVPNK VEHLWFAQLF HDRKQREERL 150
    NLSKEERAKT PYTDFLRPII ADADTGHGGI TAILKLTKLF VERGAAGIHI 200
    EDQAPGTKKC GHMAGKVLVP VQEHINRLVA IRASADILGS DLLCVARTDS 250
    EAATLLTSTI DHRDHYFVLG ATNPESPDLA ALMAEAESNG IYGDKLASIE 300
    VEWTKKAGLK LFHEAVIDEI NNGNFSNKQA LIKKFTDKVN PLSATSNKEA 350
    RKLAREILGK DVFFDWDVAR AREGYYRYQG GTQCAVMRGQ AYAPYADMIW 400
    MESALPDFKQ AKEFAEGVKA KWPDQWLAYN LSPSFNWNRA MPPNEQETYI 450
    KRLSELGYVW QFITLAGLHT TALAVDDFAN QYSQIGMRAY GQTIQAPEIE 500
    KGVEVVKHQK WSGAEYIDGL LKMVTGGVSS TAAMGAGVTE DQFKEKAAGK 550
    Length:550
    Mass (Da):61,776
    Last modified:August 16, 2004 - v1
    Checksum:iC570F0B76A9B47E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382136 Genomic DNA. Translation: CAG87204.1.
    RefSeqiXP_459036.1. XM_459036.1.

    Genome annotation databases

    GeneIDi2901192.
    KEGGidha:DEHA2D12936g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382136 Genomic DNA. Translation: CAG87204.1 .
    RefSeqi XP_459036.1. XM_459036.1.

    3D structure databases

    ProteinModelPortali Q6BRY4.
    SMRi Q6BRY4. Positions 8-527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4959.Q6BRY4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2901192.
    KEGGi dha:DEHA2D12936g.

    Phylogenomic databases

    eggNOGi COG2224.
    KOi K01637.
    OMAi ALISHQF.
    OrthoDBi EOG73Z331.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiACEA_DEBHA
    AccessioniPrimary (citable) accession number: Q6BRY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3