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Q6BRY4 (ACEA_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase
Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
Ordered Locus Names:DEHA2D12936g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces ›

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Isocitrate lyase
PRO_0000068789

Sites

Active site2101 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BRY4 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: C570F0B76A9B47E7

FASTA55061,776
        10         20         30         40         50         60 
MPYTKIDVNE EEKFFQDQVK EIQQWWKEPR WAKTKRIYQA EDIAKKRSSL KVDYPSSNQA 

        70         80         90        100        110        120 
KKLYKLLQEH DKNKSASFTF GALDPVQVTQ MAKYLDSIYV SGWQCSSTAS TSNEPSPDLA 

       130        140        150        160        170        180 
DYPMDTVPNK VEHLWFAQLF HDRKQREERL NLSKEERAKT PYTDFLRPII ADADTGHGGI 

       190        200        210        220        230        240 
TAILKLTKLF VERGAAGIHI EDQAPGTKKC GHMAGKVLVP VQEHINRLVA IRASADILGS 

       250        260        270        280        290        300 
DLLCVARTDS EAATLLTSTI DHRDHYFVLG ATNPESPDLA ALMAEAESNG IYGDKLASIE 

       310        320        330        340        350        360 
VEWTKKAGLK LFHEAVIDEI NNGNFSNKQA LIKKFTDKVN PLSATSNKEA RKLAREILGK 

       370        380        390        400        410        420 
DVFFDWDVAR AREGYYRYQG GTQCAVMRGQ AYAPYADMIW MESALPDFKQ AKEFAEGVKA 

       430        440        450        460        470        480 
KWPDQWLAYN LSPSFNWNRA MPPNEQETYI KRLSELGYVW QFITLAGLHT TALAVDDFAN 

       490        500        510        520        530        540 
QYSQIGMRAY GQTIQAPEIE KGVEVVKHQK WSGAEYIDGL LKMVTGGVSS TAAMGAGVTE 

       550 
DQFKEKAAGK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382136 Genomic DNA. Translation: CAG87204.1.
RefSeqXP_459036.1. XM_459036.1.

3D structure databases

ProteinModelPortalQ6BRY4.
SMRQ6BRY4. Positions 8-527.
ModBaseSearch...

Protein-protein interaction databases

STRING4959.Q6BRY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2901192.
KEGGdha:DEHA2D12936g.

Phylogenomic databases

eggNOGCOG2224.
KOK01637.
OMAMVTQMAK.
OrthoDBEOG4P5PJP.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_DEBHA
AccessionPrimary (citable) accession number: Q6BRY4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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