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Protein

Negative regulator of the PHO system

Gene

PHO85

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATPPROSITE-ProRule annotation
Active sitei131 – 1311Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of the PHO system (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene namesi
Name:PHO85
Ordered Locus Names:DEHA2D12980g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599 Componenti: Chromosome D

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Negative regulator of the PHO systemPRO_0000086518Add
BLAST

Interactioni

Subunit structurei

Interacts with a number of cyclins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BRY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 290283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi308 – 32720Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ6BRY2.
KOiK06655.
OMAiTLYDVIH.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6BRY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSSSQFQQ LEKLGEGTYA TVYKGRNRTN GQLVALKEIN LDSEEGTPST
60 70 80 90 100
AIREISLMKE LDHENIVTLY DVIHTENKLT LVFEFMDKDL KKYMEAHGNQ
110 120 130 140 150
GALDLKIVKS FIFQLLKGIM FCHDNRVLHR DLKPQNLLIN NKGELKLGDF
160 170 180 190 200
GLARAFGIPF NTFSNEVVTL WYRAPDVLLG SRAYTASIDI WSAGCIFAEM
210 220 230 240 250
CTGKPLFPGT SNDDQLIKIF RLMGTPNERT WPGVSSYANF KNNWQIFVPQ
260 270 280 290 300
DLRLLIPNLD SMGLNLLSSL LQMRPDARIT ARQALQHPWF HEISNPNPLM
310 320 330
QHLADPYQQS QQQSQQQAQQ SQQMDPQTYR
Length:330
Mass (Da):37,626
Last modified:December 16, 2008 - v2
Checksum:i06CFB0E01FA9F744
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382136 Genomic DNA. Translation: CAG87206.2.
RefSeqiXP_459038.2. XM_459038.1.

Genome annotation databases

GeneIDi2901523.
KEGGidha:DEHA2D12980g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382136 Genomic DNA. Translation: CAG87206.2.
RefSeqiXP_459038.2. XM_459038.1.

3D structure databases

ProteinModelPortaliQ6BRY2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2901523.
KEGGidha:DEHA2D12980g.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ6BRY2.
KOiK06655.
OMAiTLYDVIH.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHO85_DEBHA
AccessioniPrimary (citable) accession number: Q6BRY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 16, 2008
Last modified: June 24, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.