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Q6BRY2 (PHO85_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Negative regulator of the PHO system

EC=2.7.11.22
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene names
Name:PHO85
Ordered Locus Names:DEHA2D12980g
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with a number of cyclins By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Negative regulator of the PHO system
PRO_0000086518

Regions

Domain8 – 290283Protein kinase
Nucleotide binding14 – 229ATP By similarity
Compositional bias308 – 32720Gln-rich

Sites

Active site1311Proton acceptor By similarity
Binding site371ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6BRY2 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 06CFB0E01FA9F744

FASTA33037,626
        10         20         30         40         50         60 
MTGSSSQFQQ LEKLGEGTYA TVYKGRNRTN GQLVALKEIN LDSEEGTPST AIREISLMKE 

        70         80         90        100        110        120 
LDHENIVTLY DVIHTENKLT LVFEFMDKDL KKYMEAHGNQ GALDLKIVKS FIFQLLKGIM 

       130        140        150        160        170        180 
FCHDNRVLHR DLKPQNLLIN NKGELKLGDF GLARAFGIPF NTFSNEVVTL WYRAPDVLLG 

       190        200        210        220        230        240 
SRAYTASIDI WSAGCIFAEM CTGKPLFPGT SNDDQLIKIF RLMGTPNERT WPGVSSYANF 

       250        260        270        280        290        300 
KNNWQIFVPQ DLRLLIPNLD SMGLNLLSSL LQMRPDARIT ARQALQHPWF HEISNPNPLM 

       310        320        330 
QHLADPYQQS QQQSQQQAQQ SQQMDPQTYR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382136 Genomic DNA. Translation: CAG87206.2.
RefSeqXP_459038.2. XM_459038.1.

3D structure databases

ProteinModelPortalQ6BRY2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.Q6BRY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2901523.
KEGGdha:DEHA2D12980g.

Phylogenomic databases

eggNOGCOG0515.
KOK06655.
OMAQVPQNAY.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHO85_DEBHA
AccessionPrimary (citable) accession number: Q6BRY2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families