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Protein

Negative regulator of the PHO system

Gene

PHO85

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37ATPPROSITE-ProRule annotation1
Active sitei131Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of the PHO system (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene namesi
Name:PHO85
Ordered Locus Names:DEHA2D12980g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865181 – 330Negative regulator of the PHO systemAdd BLAST330

Interactioni

Subunit structurei

Interacts with a number of cyclins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BRY2
SMRiQ6BRY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 290Protein kinasePROSITE-ProRule annotationAdd BLAST283

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi308 – 327Gln-richAdd BLAST20

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ6BRY2
KOiK06655
OMAiRHTNETI
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BRY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSSSQFQQ LEKLGEGTYA TVYKGRNRTN GQLVALKEIN LDSEEGTPST
60 70 80 90 100
AIREISLMKE LDHENIVTLY DVIHTENKLT LVFEFMDKDL KKYMEAHGNQ
110 120 130 140 150
GALDLKIVKS FIFQLLKGIM FCHDNRVLHR DLKPQNLLIN NKGELKLGDF
160 170 180 190 200
GLARAFGIPF NTFSNEVVTL WYRAPDVLLG SRAYTASIDI WSAGCIFAEM
210 220 230 240 250
CTGKPLFPGT SNDDQLIKIF RLMGTPNERT WPGVSSYANF KNNWQIFVPQ
260 270 280 290 300
DLRLLIPNLD SMGLNLLSSL LQMRPDARIT ARQALQHPWF HEISNPNPLM
310 320 330
QHLADPYQQS QQQSQQQAQQ SQQMDPQTYR
Length:330
Mass (Da):37,626
Last modified:December 16, 2008 - v2
Checksum:i06CFB0E01FA9F744
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382136 Genomic DNA Translation: CAG87206.2
RefSeqiXP_459038.2, XM_459038.1

Genome annotation databases

EnsemblFungiiCAG87206; CAG87206; DEHA2D12980g
GeneIDi2901523
KEGGidha:DEHA2D12980g

Similar proteinsi

Entry informationi

Entry nameiPHO85_DEBHA
AccessioniPrimary (citable) accession number: Q6BRY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health